PSSD Collaborative Research

I have started berberine at 200mg 4x day with ABS World 60 Icariin 300 mg 3x per day as per area-1229's protocol, but I am open to different dosing schedules (e.g.: if more berberine might be better, but most user's experiences seem to be better at lower doses). Also started Citrulline, will keep...

Hello Mesolimbo . I am new here. I get Mechanical numbness and Erogenous numbness from Escitalopram . I lost all my sexual pleasures. When my genitals being touched , i can hardly feel it , and it can not generate pleasure at all. When i am kissing or my perianal and prostate being touched i can...

I have repeatedly confirmed that Gotu Kola works short-term for sensitivity (same day, for 1-3 days or so). Bacopa I think is short-term no use for sensitivity (perhaps libido and arousal), but perhaps longterm a good support for Gotu Kola. (They are both traditional complements anyway.) I have...

must be easy to test with a PPARy agonist like pioglitazone PPARa agonist fenofibrate seems to have the opposite effect on AR in prostate cells if the same applies to penis tissue and going by this study on finasteride showing doubled AR expression in the penis may be that could reverse androgen...

You could try out a Jujube extract which may be a postsynaptic 5HT1A antagonist , for the purpose of upregulation. I was trying 1-5g at night for a few weeks which coincided with some symptom improvements, but I'm not sure if it was due to jujube. CBD may be a 5HT1A agonist. Some have reported...

Pssd could be caused by inhibition of dopamine, and or lack of dopamine. Many with PSSD suffer from anhedonia (Anhedonia and sexual anhedonia). If you lower dopamine you will get anhedonia and could also suffer derealization/depersonalization symptoms and other dysphoric feelings. From wikipedia...

For example, you might write that if one takes cabergoline and experiences no improvement, then their XYZ pathway is probably functioning properly, therefore they should shift their focus to the ABC pathway, which they can evaluate by taking some other pharmaceutical. And so on until the problem is...

Postsynaptic 5ht1a receptor decrease acetylcholine and glutamate in hippocampus- maybe is do you mean? Muscarinic receptor is antidopaminergic, muscarinic antagonist disinhibition dopamine.

Yes! I am in a relationship and I am successful. But the most important thing is to please myself, that's why my dream has always been to change my appearance to more narcissistic, agressive.

could anyone suggest presynaptic 5ht1a antagonist ?

Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression. This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABAA receptor – moderate level increases (in the range of 1.5–2 nM/L total...

Increasingly, I believe in your theories about: presynaptic 5ht1a supersensitivity or downregulation postsynaptic 5ht1a. Especially since: presynaptic 5ht1a = increase rem sleep postsynaptic 5ht1a = block rem sleep. I read your article and associated it with: tonic dopamine activation: creepy...

I tried Chinese Schisandra and turmeric, it didn't help me.

Is there evidence to support over expression of GR induced by ssri?

I’m going to be trialing truvada for this reason. A member on I believe propecia help cured his symptoms accidentally with truvada.

Good find. Fluoxetine has always given me emotional blunting. One of my best friends passed away at age 21 and I couldn't feel any true sadness about what had happened. I remember drinking half a bottle of alcohol just to feel some sort of sorrow. Luckily I can still feel a normal array of sadness...

If the problem is psychological, EMDR might work.

I found a peptide site to order astressin b (crh2 antagonist). It’s as close as I can get to Cortene. It will take years if ever to get our hands on Cortene. I don’t want to wait. Going to go for it in the upcoming month.

Ketamine also made symptoms better in days after dosing. But like shrooms, it didn't last. The thing about PSSD is, some people actually get permanently cured, it's not unheard of, but for how long have they been suffering from PSSD in the first place? I think the longer you suffer from PSSD, the...

2 weeks treatment with the herbal extract SJW significantly reduced the plasma AUC and Cmax of finasteride by approximately 50. just FYI Not sure what you're getting at here. SJW is known to change the metabolism of many drugs

Chemical castration in rats also changes serotonin levels and 5-ht1A receptor functioning, this relates to androgens and mood and sexuality.

Italy OK. 8-) 8-) 8-)

As mentioned in the post above, SSRI's and also other antidepressants modulate brain steroids that has important roles in sexual function. Various antidepressants, including the SSRIs fluoxetine, fluvoxamine, sertraline, and paroxetine, the SNRI venlafaxine, and mirtazapine, have been found to...

No! In fact, there are a lot of people who criticize "oh Ghost and his crazy forum thinking you have epigenetic changes". This argument is BULLSHIT!!! You have epigenetic changes from diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants,...