PSSD Collaborative Research

A forum dedicated to collaborative research into PSSD (Post-SSRI Sexual Dysfunction).

PSSD related research

Moderators: Ghost, Sonny

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New Dr. Goldstein Research [YOUR HELP NEEDED!!!]
1, 2, 3by Ghost » Wed Oct 23, 2019 8:19 pm

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Last post by Sheep
Wed Dec 04, 2019 2:06 am

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No, nothing like that. He was very sympathetic and helpful, willing to try a few different treatments with me. He just comes from a pretty evidence based perspective and said that Goldstein's latter day views generally aren't accepted as being such, despite having had a very respected earlier...
PSSD Resources
by Ghost » Mon Jan 30, 2017 11:38 am

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Last post by siebs1122
Mon Jan 30, 2017 9:56 pm

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Thanks for doing this Ghost, it looks like a great start.
Forum Rules
by Ghost » Tue Nov 22, 2016 11:19 am

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Last post by Ghost
Tue Nov 22, 2016 11:19 am

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PSSD research looking for patients (Enrollment extended)
1 ... 8, 9, 10by Maldoror » Fri Jul 24, 2015 4:25 pm

95 Replies

47379 Views

Last post by future-recovery
Sat Nov 30, 2019 2:48 pm

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Does anyone know when the study will be published?
PSSD Genome Project [Megathread]
1 ... 27, 28, 29by Ghost » Tue Apr 24, 2018 5:57 pm

284 Replies

248627 Views

Last post by sovietxrobot
Tue Oct 22, 2019 7:11 am

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Paper on the genetic effects of citalopram: Kanherkar et al. 2018. The effect of citalopram on genome-wide DNA methylation of human cells. International Journal of Genomics. In short: Human cell culture exposed to citalopram for a month. OXT gene downregulated, inhibition of dopa pathway. Coincides...
Participants wanted for PSSD study. Contact: sulawesi1@web.de
1 ... 30, 31, 32by sulawesi » Fri Feb 10, 2017 7:30 am

314 Replies

61392 Views

Last post by lw77
Thu Sep 13, 2018 11:22 am

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Guys but what happened to the study? Had it been done?
Ghost's Neuroscience Corner
1, 2by Ghost » Fri Sep 18, 2015 12:29 pm

10 Replies

11389 Views

Last post by Ghost
Sun Jul 29, 2018 11:22 am

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I've moved my educational-type postings to my website.
Tryptophan Depletion
1, 2by Ghost » Sun Oct 11, 2015 10:23 am

16 Replies

8574 Views

Last post by PsychoGenesis
Thu Dec 05, 2019 4:51 am

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or you can filter it here
World first as artificial neurons developed to cure chronic diseases 2019
by anacleta » Tue Dec 03, 2019 1:18 pm

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112 Views

Last post by anacleta
Tue Dec 03, 2019 1:18 pm
New study reveals the epigenetic effects of Citalopram
1 ... 8, 9, 10by nasibi » Sat Oct 20, 2018 11:56 pm

91 Replies

15012 Views

Last post by ac3c
Thu Nov 28, 2019 9:02 am

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plz stop with nonsense plz What we need is counter arguments to why decitibine or valpro wouldn't work Plz people with medical knowledge theories here Decitibine is just too dangerous to test. The risk of collateral damage is huge. Hell, lets pretend we knew it would have an effect. The question...
Post-synaptic 5HT1A receptors inhibit NMDA and genital sensitivity?
1, 2by enriqueiglesias » Sun Sep 22, 2019 9:03 am

10 Replies

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Last post by sylv
Sun Nov 24, 2019 4:34 am

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What seems to "cure" me is a drug called Cyproheptadine (Periactin), which is a known serotonin antagonist. But the weird component is this. When I take 1mg of this drug, I will be sleepy (normal response) and wake up feeling tired. The following day I feel the same. BUT it's day 3 and 4...
Berberine
1 ... 11, 12, 13by Moloch » Sat Feb 07, 2015 4:29 am

122 Replies

25978 Views

Last post by ErgogenicHealth
Wed Nov 20, 2019 10:38 pm

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What effect do you suppose berberine would have? “The anxiolytic mechanism of BER might be related to the increase in turnover rates of monoamines in the brain stem and decreased serotonergic system activity. Moreover, BER decreased serotonergic system activity via activation of somatodendritic...
Lesser-known tidbits on Bupropion
by Meso » Sat Nov 09, 2019 4:28 am

9 Replies

1084 Views

Last post by PsychoGenesis
Sun Nov 10, 2019 2:00 pm

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4. this is why people report that agmatine prevent their tolerance to bupropion effects 5. may be why it increases the risk of psychosis
Antipsychotics, 5α-reductase inhibitors, SSRI’s, SNRI’s and TCA’s do all mess with neurosteroids!
by quagmire » Wed Apr 17, 2019 9:09 am

3 Replies

2208 Views

Last post by iull1k
Wed Oct 23, 2019 3:58 am

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Yeah you are right, but that's not new. This theory is seriously considered by propeciaforum admins.
Gotu Kola (Centella Asiatica) and Bacopa on GluR1, 2 and NR2A, B
by enriqueiglesias » Thu Aug 29, 2019 9:48 am

6 Replies

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Last post by enriqueiglesias
Mon Oct 21, 2019 6:08 am

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Regarding dosage: it may not be limited to a low dosage, but standardized extract may work better over time (what I had tried first). Adverse reactions may come from immediate effect compared to waiting a bit. Or purity may make extract better. (Powder still works and is how it's mostly sold and...
Genital numbness/anesthesia: the science
by Meso » Sun Sep 29, 2019 4:38 am

7 Replies

1495 Views

Last post by ziran0
Tue Oct 08, 2019 8:06 am

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Hello Mesolimbo . I am new here. I get Mechanical numbness and Erogenous numbness from Escitalopram . I lost all my sexual pleasures. When my genitals being touched , i can hardly feel it , and it can not generate pleasure at all. When i am kissing or my perianal and prostate being touched i can...
FOUND THE CAUSE OF PSSD!!! SEROTONIN - PPARy - nNOS *REVEALED*
by JayR » Wed Aug 07, 2019 6:47 am

7 Replies

1908 Views

Last post by PsychoGenesis
Thu Oct 03, 2019 8:02 am

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must be easy to test with a PPARy agonist like pioglitazone PPARa agonist fenofibrate seems to have the opposite effect on AR in prostate cells if the same applies to penis tissue and going by this study on finasteride showing doubled AR expression in the penis may be that could reverse androgen...
SSRi-induced Parkinsonism
by sovietxrobot » Wed Sep 18, 2019 11:05 am

2 Replies

1281 Views

Last post by quagmire
Wed Sep 18, 2019 12:07 pm

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Pssd could be caused by inhibition of dopamine, and or lack of dopamine. Many with PSSD suffer from anhedonia (Anhedonia and sexual anhedonia). If you lower dopamine you will get anhedonia and could also suffer derealization/depersonalization symptoms and other dysphoric feelings. From wikipedia...
On sexual desire systems and loss of libido [Part 1]
1, 2by Meso » Tue Sep 17, 2019 5:52 am

16 Replies

2320 Views

Last post by sovietxrobot
Wed Sep 18, 2019 12:04 pm

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For example, you might write that if one takes cabergoline and experiences no improvement, then their XYZ pathway is probably functioning properly, therefore they should shift their focus to the ABC pathway, which they can evaluate by taking some other pharmaceutical. And so on until the problem is...
SSRI blocks Muscarinic acetylcholine receptors, could lead to sexual dysfunction
by quagmire » Wed Sep 18, 2019 5:37 am

2 Replies

1296 Views

Last post by finities infinities
Wed Sep 18, 2019 6:43 am

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Postsynaptic 5ht1a receptor decrease acetylcholine and glutamate in hippocampus- maybe is do you mean? Muscarinic receptor is antidopaminergic, muscarinic antagonist disinhibition dopamine.
GnRH/kisspeptin/nkb/GNIH
1, 2by kpavel » Fri Aug 16, 2019 7:57 am

10 Replies

1519 Views

Last post by finities infinities
Sat Sep 14, 2019 6:38 am

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Yes! I am in a relationship and I am successful. But the most important thing is to please myself, that's why my dream has always been to change my appearance to more narcissistic, agressive.
Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression
by iull1k » Thu May 02, 2019 5:17 am

7 Replies

1993 Views

Last post by fellow1
Sat Aug 31, 2019 1:03 am

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could anyone suggest presynaptic 5ht1a antagonist ?
L-Cysteine far better than Acetyl-Cysteine?
by enriqueiglesias » Tue Aug 27, 2019 3:21 pm

0 Replies

1269 Views

Last post by enriqueiglesias
Tue Aug 27, 2019 3:21 pm
On progesterone and allopregnanolone: effects on the central nervous system (CNS)
by Meso » Sun Jul 21, 2019 6:44 am

7 Replies

1149 Views

Last post by lukejimmy
Mon Aug 26, 2019 8:36 pm

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Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression. This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABAA receptor – moderate level increases (in the range of 1.5–2 nM/L total...
New review: on to dopamine phasic & tonic release [116 studies]
1, 2, 3by Meso » Tue Aug 06, 2019 5:31 am

23 Replies

2326 Views

Last post by finities infinities
Sat Aug 24, 2019 10:26 am

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Increasingly, I believe in your theories about: presynaptic 5ht1a supersensitivity or downregulation postsynaptic 5ht1a. Especially since: presynaptic 5ht1a = increase rem sleep postsynaptic 5ht1a = block rem sleep. I read your article and associated it with: tonic dopamine activation: creepy...
Transcriptional dysregulation of 5-HT1A autoreceptors
by iull1k » Wed Jul 25, 2018 11:33 pm

3 Replies

3078 Views

Last post by Tree
Mon Jul 29, 2019 2:34 pm

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Is there evidence to support over expression of GR induced by ssri?
PSSD - an infection blocks recovery ?
by north4 » Sun Jul 21, 2019 9:38 pm

3 Replies

796 Views

Last post by Maxin
Mon Jul 22, 2019 2:36 pm

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I’m going to be trialing truvada for this reason. A member on I believe propecia help cured his symptoms accidentally with truvada.
AD treatment, not depression, leads to reductions in behavioral and neural responses to pain empathy
by north4 » Wed Jul 17, 2019 2:33 am

1 Replies

638 Views

Last post by Gameclay
Wed Jul 17, 2019 7:57 am

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Good find. Fluoxetine has always given me emotional blunting. One of my best friends passed away at age 21 and I couldn't feel any true sadness about what had happened. I remember drinking half a bottle of alcohol just to feel some sort of sorrow. Luckily I can still feel a normal array of sadness...
found a pssd success story they didn't even know pssd existed
by Imtrying34 » Sat May 25, 2019 9:44 am

7 Replies

1006 Views

Last post by elliotstone
Tue Jul 16, 2019 2:36 pm

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If the problem is psychological, EMDR might work.
Cortene drug trial/Astressin B
1, 2, 3by Maxin » Wed Feb 06, 2019 1:25 pm

22 Replies

4154 Views

Last post by Maxin
Sun Jul 14, 2019 4:00 pm

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I found a peptide site to order astressin b (crh2 antagonist). It’s as close as I can get to Cortene. It will take years if ever to get our hands on Cortene. I don’t want to wait. Going to go for it in the upcoming month.
Why is PSSD so damn persistent and treatment-resistant: more insight into the glutamatergic system
by Meso » Sat Jul 06, 2019 10:49 am

3 Replies

893 Views

Last post by Meso
Wed Jul 10, 2019 12:32 am

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Ketamine also made symptoms better in days after dosing. But like shrooms, it didn't last. The thing about PSSD is, some people actually get permanently cured, it's not unheard of, but for how long have they been suffering from PSSD in the first place? I think the longer you suffer from PSSD, the...
The epigenetic changes triggered by antidepressant intake and withdrawal: the PSSD connection
by Meso » Fri Jul 05, 2019 7:13 am

0 Replies

531 Views

Last post by Meso
Fri Jul 05, 2019 7:13 am
SJW may have 5-AR Inhibiting properties
by Gameclay » Mon Jul 01, 2019 3:22 pm

2 Replies

518 Views

Last post by Gameclay
Mon Jul 01, 2019 7:29 pm

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2 weeks treatment with the herbal extract SJW significantly reduced the plasma AUC and Cmax of finasteride by approximately 50. just FYI Not sure what you're getting at here. SJW is known to change the metabolism of many drugs

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