PSSD Collaborative Research

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Could somebody please merge this with this thread? . I may have something to report regarding this condition soon, but I think it would be helpful to have everything in one place first :)

Hallo, Warum dürfen sich eigentlich keine Frauen beteiligen? Gibt es zwischen den zwei Geslechtern wesentliche Unterschiede, wodurch weibliche Teilnehmerinnen keinen gleichen Wert hätten? Wer sagt das Frauen nicht teilnehmen dürfen ? / Who is saying women cant be part of study ? edit: Vieleicht...

Good news is :

When these are depleted how do you build up the storage again? Just by eating multi vitamin?

Yea this is Dr. Albert's work. I think he's from Canada if I remember right. He's the go-to guy for the 5HT1A receptor from the genetic standpoint.

Just a word of warning. Buspirone CAUSED my PSSD (either alone or with venlafaxine and bupropion)! I took almost all SSRI/SNRI before and didn't have that problem. For more info see my intro.

I could hardly see anyone live with muscle problems with PSSD. This aspect of disease bothering me more than sexual ones. She could heal within 6-7 months. If we assume she didn't have pssd, it's still such a long time.

No! In fact, there are a lot of people who criticize "oh Ghost and his crazy forum thinking you have epigenetic changes". This argument is BULLSHIT!!! You have epigenetic changes from diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants,...

If you have an actual form from a lawyer i will sign it, don't know where my information is going and too scared to give it out

Licorice root is also estrogenic, which may have been another factor in helping you recover your libido. Sadly, I have the opposite problem. Way too much adrenaline and estrogen which can both cause ED and premature aging.

Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology Antonei B. Csokaa,*, Moshe Szyf "Besides stimulants, SSRI antidepressants have been shown to cause long-term alterations in gene expression, presumably resulting from chronic elevation of...

Enhancement of presynaptic glutamate using octopamine? Could this help? Please excuse my ignorance of neuroscience.

please write to many researchers of neurology and epigenetic putting this your idea and trying to get them interested in the pssd problem.

I'm really interested in this, if you have the raw file from 23andMe: 1.) Open the raw data (it's in notepad form) 2.) Right click anywhere in the notepad 3.) Hold the "Ctrl" key and press the "f" key 4 Copy and paste "rs7574865" into the search thingy and right click...

Down regulation of HDAC2 and upregulation of Histone acetylation are good. It leads to higher transcription.

I was told to give you the following information: A few days ago nick911 from Germany (not a member of the pssdforum) had a phone call with Dr. Melcangi: german messag servus leute! Ein paar wichtige dinge: mich hat vorhin der prof. melcangi aus mailand angerufen und mich über die studie in ulm...

I would think epigenetic therapy would be more helpful: On another note if gene therapy is the only real possibility wouldn't that mean someone who's an only child and who's parents are dead, would be out of luck? SSRIs can damage sperm DNA integrity, is this reversible?

I definitely going to try Insoitol, it will make 5HT2 more sensitive and Trazodone will have a big impact on 5HT2. But I still think the 5HT1 has something to do with it. Seriously, after only one ginkgo tablet (pro 5HT1) my scrotum became more numb again, the skin smooth, greasy and wrinkled....

This is an interesting concept. Doctors who are familiar with treating PFS patients theorize something similar with the androgens. Read this blog post. "If high normal levels of testosterone, combined with low estrogen levels, does not relieve the hypogonadal symptoms, then the possibility...

@Ghost, Juvo feel free to move my post to the trial section if needed, i couldnt as it was locked. I wanted to share my experience with Levonorgestrel, as it has been mentioned a couple of times already. Some people have talked about the possible benefits, and some have tried it without any effect....

has no one else tried this? i took fish oil before but not cod oil