PSSD Collaborative Research

I tried Chinese Schisandra and turmeric, it didn't help me.

Interesting read. I wonder if Melanotan II is worth trying because of this. It's been known to increase libido Ive tried Melanotan II and PT 141. They gave me crazy hard eretions but no libido I never tried, on the one hand I also didn't see any study about strong MC4receptor downregulation or...

Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production, and neuronal NO synthase expression in rat corpus cavernosum tissue. While high levels of dopamine are related to promoting sexual function, high levels of serotonin, in general, are thought to inhibit...

I can confirm, I have experiences intense sexual emotions and feelings whilst asleep. Upon waking though, that's another story - back to emotional blunting nothingness. Sleep deprivation also helps greatly with being able to 'feel' again. Sleeping 'resets' me back to crapness. Sleep deprivation...

Is there evidence to support over expression of GR induced by ssri?

This can also be a link between Accutane, PFS, and PSSD. Accutane upregulates the presynaptic 5HT1A and SERT mRNA expression. This can cause drastically less activation of 5HT2A and downregulation of 5alpha-reductase mRNA expression. I've discovered recently that my type of PSSD is due to...

I’m going to be trialing truvada for this reason. A member on I believe propecia help cured his symptoms accidentally with truvada.

Good work as always, meso - making a complex topic a bit more digestible and furthering our understanding of this condition. I find it interesting how some of us have increased anxiety, lowered (or no) anxiety, or just baseline anxiety. How does this fit in with the insensitivity to allogrep? Since...

Good find. Fluoxetine has always given me emotional blunting. One of my best friends passed away at age 21 and I couldn't feel any true sadness about what had happened. I remember drinking half a bottle of alcohol just to feel some sort of sorrow. Luckily I can still feel a normal array of sadness...

If the problem is psychological, EMDR might work.

I found a peptide site to order astressin b (crh2 antagonist). It’s as close as I can get to Cortene. It will take years if ever to get our hands on Cortene. I don’t want to wait. Going to go for it in the upcoming month.

Ketamine also made symptoms better in days after dosing. But like shrooms, it didn't last. The thing about PSSD is, some people actually get permanently cured, it's not unheard of, but for how long have they been suffering from PSSD in the first place? I think the longer you suffer from PSSD, the...

Bump, this topic was too interesting to leave behind. Did anyone give this a try meanwhile?

2 weeks treatment with the herbal extract SJW significantly reduced the plasma AUC and Cmax of finasteride by approximately 50. just FYI Not sure what you're getting at here. SJW is known to change the metabolism of many drugs

Chemical castration in rats also changes serotonin levels and 5-ht1A receptor functioning, this relates to androgens and mood and sexuality.

Italy OK. 8-) 8-) 8-)

As mentioned in the post above, SSRI's and also other antidepressants modulate brain steroids that has important roles in sexual function. Various antidepressants, including the SSRIs fluoxetine, fluvoxamine, sertraline, and paroxetine, the SNRI venlafaxine, and mirtazapine, have been found to...

No! In fact, there are a lot of people who criticize "oh Ghost and his crazy forum thinking you have epigenetic changes". This argument is BULLSHIT!!! You have epigenetic changes from diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants,...

@jayR what about being good enough and sharing ur pssd recovery if u rly had it? whats ur curently on? -yohimbe -prasozin -cialis -dextroamphetamine -metergoline u use these or none of this? sry but i look u as another internet prophet until u give the community something realistic and sincere...

Although there's a wide range of normal, an unusually high or low heart rate may indicate an underlying problem. Consult your doctor if your resting heart rate is consistently above 100 beats a minute (tachycardia) or if you're not a trained athlete and your resting heart rate is below 60 beats a...

Thanks for posting this Link11. It's very interesting.

Both me and been_too_long have discussed possible involvement of oxytocin in our readings from sexual health journals. But still at a loss how to connect the dots. One of thr glaring observations made by this study was how chronic use of SSRIs affect or cause sexual dysfunction. But what about...

I can also agree whit this

Does it cause PSSD (although it wouldn't be called that!) by itself or only worsen PSSD for those who already have it?