PSSD Collaborative Research

A forum dedicated to collaborative research into PSSD (Post-SSRI Sexual Dysfunction).

PSSD related research

Moderators: Ghost, Sonny

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PSSD Genome Project [Megathread]
1 ... 24, 25, 26by Ghost » Tue Apr 24, 2018 5:57 pm

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Last post by Ghost
Fri Feb 08, 2019 11:29 am

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I've published the results from this summer on my site: There are only three SNPs that I go into depth on. I cut out a lot of them that didn't meet strict protocol. These three deserve further analysis by the community. Since I started working on this report, I have received many new genomes. These...

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PSSD research looking for patients (Enrollment extended)
1 ... 8, 9, 10by Maldoror » Fri Jul 24, 2015 4:25 pm

93 Replies

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Last post by Johnson
Mon Nov 26, 2018 1:15 am

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Any update on this?
Participants wanted for PSSD study. Contact: sulawesi1@web.de
1 ... 30, 31, 32by sulawesi » Fri Feb 10, 2017 7:30 am

314 Replies

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Last post by lw77
Thu Sep 13, 2018 11:22 am

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Guys but what happened to the study? Had it been done?
Ghost's Neuroscience Corner
1, 2by Ghost » Fri Sep 18, 2015 12:29 pm

10 Replies

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Last post by Ghost
Sun Jul 29, 2018 11:22 am

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I've moved my educational-type postings to my website.
"Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine"
1, 2by fakeaccount » Sat Feb 09, 2019 1:57 pm

11 Replies

408 Views

Last post by sovietxrobot
Wed Feb 20, 2019 2:37 pm
Discussion on Simonsen Systematic Review
by lw77 » Sun Feb 17, 2019 2:43 pm

1 Replies

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Last post by NeverBeenTold
Mon Feb 18, 2019 12:16 am

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4.3. Implications Our results suggest that patients should be informed before they are being prescribed SSRIs, that these drugs may cause long-lasting or perhaps even permanent harm on sexual function that persists after the patients have come off the drugs. Our results also provide support to...
Berberine
1 ... 8, 9, 10by Moloch » Sat Feb 07, 2015 4:29 am

90 Replies

16382 Views

Last post by IHateProzac
Tue Feb 12, 2019 4:54 pm

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How does berberine interact with PDE5i's like Viagra? From what I've read Berberine inhibits cytochrome P450 3A4 (CYP3A4). PDE5i's are metabolized by that enzyme. So I would speculate clearence of pde5i's decreases when combined. Meaning the effects will last longer and could possibly cause...
Cortene drug trial/Astressin B
by Maxin » Wed Feb 06, 2019 1:25 pm

9 Replies

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Last post by Maxin
Tue Feb 12, 2019 12:46 pm

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Cyproheptadine, which I started trialing yesterday, drastically reduces ACTH release and is used off-label for Cushing's. It does so by interfering with CRF function on the pituitary, possibly by blocking CRF receptors. Cypro also happens to be a potent anti-serotonergic agent used in management of...
Long-term harms from previous use of SSRIs: A systematic review. 2019
by anacleta » Sat Feb 09, 2019 4:54 am

1 Replies

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Last post by sylv
Sat Feb 09, 2019 6:18 am

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6 years ago I've asked my psych what are long term effects from AD use and it has greatly confused him. He gave only non-specific answers and gently changed the topic. Guess nothing has changed.
Imipramine treats citalopram PSSD in rats
1, 2by Blueturtle » Sat Dec 15, 2018 9:55 pm

13 Replies

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Last post by Blueturtle
Fri Feb 08, 2019 11:45 pm

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Yes technically the rats in the clomipramine study didn’t have “post SSRI sexual dysfunction” but clomipramine does block the reuptake of serotonin and norepinephrine “10 times more affinity for serotonin then noripinephribe” Citalopram just blocks the reuptake of serotonin I don’t have access to...
Ion channel/nerve research posted on PSSDlab
by Blueturtle » Sat Feb 02, 2019 11:28 pm

4 Replies

485 Views

Last post by Ghost
Mon Feb 04, 2019 5:01 pm

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Thanks for posting this! Looking over it again was good refresher!
Does anyone have anything to say about this study?
by Ciprofloxacin » Sat Feb 02, 2019 2:15 pm

2 Replies

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Last post by scripy3
Sun Feb 03, 2019 2:35 pm

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I had always wondered the reason why receptors don't bounce back to their normal state after antidepressants. I'm still wondering tbh. How about immune system? There is relation immune system - 5-ht sytem To some this can be true, maybe to some it's hormone The studies are random. but have a look
GABA A3/4/5, inflammation and mitochondria
1, 2, 3by Ciprofloxacin » Wed Sep 05, 2018 12:14 am

28 Replies

5104 Views

Last post by Maxin
Sat Feb 02, 2019 3:42 pm

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Yes of course. I first tried dexamethasone years ago. I was a professional dancer and had to get through a performance, so docs gave me a weeks worth as I was having such bad fatigue. This was a few months after stopping ssri. It did help but he only prescribed for a week. But this led to me to...
"Heart rate variability biofeedback increases sexual arousal" 2018
by anacleta » Thu Jan 10, 2019 6:27 am

0 Replies

246 Views

Last post by anacleta
Thu Jan 10, 2019 6:27 am
8-oh-dpat treats clomipramine PSSD in rats
by Blueturtle » Mon Dec 24, 2018 8:33 pm

4 Replies

786 Views

Last post by Blueturtle
Tue Jan 08, 2019 6:24 pm

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Yeah, it’s clear that a giant pinch of salt should be taken with any animal study trying to link it to potential human treatments. I just posted it because it’s another hopeful sign that we can help ourselves with SOMETHING with the fact that sexual deficits in animals from early serotonin drugs...
Alpha:Beta activity in PSSD.
1, 2by JayR » Mon Jan 07, 2019 10:55 am

13 Replies

737 Views

Last post by JayR
Tue Jan 08, 2019 2:22 pm

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@jayR what about being good enough and sharing ur pssd recovery if u rly had it? whats ur curently on? -yohimbe -prasozin -cialis -dextroamphetamine -metergoline u use these or none of this? sry but i look u as another internet prophet until u give the community something realistic and sincere...
"Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction" 2012
by anacleta » Sat Sep 08, 2018 11:34 pm

3 Replies

3051 Views

Last post by JayR
Tue Jan 08, 2019 1:51 pm

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Mine is normal = no increased/decreased risk for SSRI-induced Sexual Dysfunction.
"Efficacy of testosterone combined with a PDE5 inhibitor and testosterone combined with a .." 2015
by anacleta » Sat Sep 08, 2018 11:39 pm

1 Replies

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Last post by JayR
Tue Jan 08, 2019 1:50 pm

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Yeah, or PT-141. It works for Women pretty well too!!!
Pramipexole - D2, L-arginine and PDE-I
by magnilo » Wed Nov 14, 2018 2:04 am

1 Replies

665 Views

Last post by JayR
Tue Jan 08, 2019 1:47 pm

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I've found this study and to be honest im fairly puzzled, my knowledge is very superficial and mostly limited to SE/NE/DA receptors, so id appreciate if someone with a more in depth knowledge could make some sense out of this the following study investigate the effects of coadministration of...
interesting info on 5ht2a
by iggy131313 » Wed May 06, 2015 8:27 am

6 Replies

4030 Views

Last post by umapinha
Fri Dec 21, 2018 3:12 pm

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I definitely going to try Insoitol, it will make 5HT2 more sensitive and Trazodone will have a big impact on 5HT2. But I still think the 5HT1 has something to do with it. Seriously, after only one ginkgo tablet (pro 5HT1) my scrotum became more numb again, the skin smooth, greasy and wrinkled....
New study reveals the epigenetic effects of Citalopram
1 ... 5, 6, 7by nasibi » Sat Oct 20, 2018 11:56 pm

63 Replies

7627 Views

Last post by londonexec
Thu Nov 29, 2018 3:44 pm

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hes using emitricibine/tenofovir,the green one from this site i used to get mine from here too, but seems like their site is having lots of issues lately... order from now and haven't had any problems getting it on time
Promising new contact to German scientist
1, 2by sulawesi » Tue Nov 20, 2018 7:36 am

14 Replies

1698 Views

Last post by Johnson
Wed Nov 28, 2018 9:43 pm

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Good news, thank you guys!
Lichen sclerous/balanitis xerotica
1, 2by Marksanchez397 » Tue Jun 19, 2018 5:58 am

15 Replies

3976 Views

Last post by ninja13
Tue Nov 27, 2018 8:17 pm

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Wow, I did not expect to see a thread like this. I have this condition. The strangest thing is, this all coincided with my introduction into anhedonia, and whilst I was on prozac! I should point out, I don't have PSSD(please do not kick me out). I never got that, as odd as it may be. But prozac did...
Desmodium Ascends
1, 2, 3by continue » Fri Mar 10, 2017 8:09 am

29 Replies

5943 Views

Last post by ninja13
Tue Nov 27, 2018 7:49 pm

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Sorry, I know that this is a very old thread, but I would just like to make the op and anyone else who is interested aware of something. Desmodium adscendens for those that may not be aware, is "the" most potent potassium channel opener known to man. Now there has just been a study where...
Progesterone
1 ... 21, 22, 23by Ghost » Mon Jul 24, 2017 12:46 am

226 Replies

35080 Views

Last post by Marcopol
Mon Nov 26, 2018 12:40 am

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MTP kit crams progesterone to terminate pregnancy.
Possible PSSD Study criteria
1, 2, 3by sulawesi » Thu Mar 16, 2017 10:56 am

28 Replies

6619 Views

Last post by mxh
Fri Oct 26, 2018 5:24 pm

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There is no doctor's certificate required for point 5. As at the some other points you have to folow you experience... Don't know what you mean. A diagnosis is always from a doctor. I was diagnosed PSSD. Just ask your doctor. It's not possible to expect them to even know about this, as they don't...
I healed pssd and ahendonia 80 percent success from numbness until adderal 5mg
1, 2, 3by Imtrying34 » Wed Oct 24, 2018 7:43 am

26 Replies

4202 Views

Last post by Imtrying34
Thu Oct 25, 2018 4:26 am

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All, lets not shit talk amphetamines. None of us are here because of amphetamines. I've used low doses of adderall for 20 years and its always been a friend. I stopped taking it for a year after I got pssd, but restarted when I had a kid and needed the boost. I don't reccommend high doses but 5mg...
David Healy research about PSSD
1, 2, 3by brman » Sun Jan 25, 2015 8:56 pm

22 Replies

8114 Views

Last post by anacleta
Mon Oct 15, 2018 12:41 am

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I do not think that a personal intolerance can make Healy a charlatan. and not even different theories about a problem for which there is currently no valid solution. Has Healy ever sold fake miracle therapies etc? no. What's the problem with getting noticed? if it does not, how do the articles on...
I guess I'm getting better over time
1, 2, 3, 4, 5by PLZNO » Wed Nov 09, 2016 3:41 am

40 Replies

10728 Views

Last post by Dead
Sat Oct 13, 2018 10:29 am

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Good to hear PLZNO, glad you're doing better. Good luck in the army. Might do good for you, getting your mind off of this etc.
GABAA receptor modulating steroid antagonists (GAMSA)
by Ciprofloxacin » Thu Oct 11, 2018 5:52 am

0 Replies

2438 Views

Last post by Ciprofloxacin
Thu Oct 11, 2018 5:52 am
Chronic escitalopram treatment induces erectile dysfunction by decreasing nitric oxide bioavailabili
by raskolnikov » Fri Oct 05, 2018 11:11 am

2 Replies

2836 Views

Last post by anacleta
Fri Oct 05, 2018 11:17 pm

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I have sexual desire. I have no genital anesthesia to the touch. I have no emotional flattening. I no longer experience sexual arousal and pleasure in the stimulation of the clitoris. I reach orgasm that does not give pleasure anymore. both in the phase of lack of congestion / genital excitation...

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