PSSD Collaborative Research

A forum dedicated to collaborative research into PSSD (Post-SSRI Sexual Dysfunction).

PSSD related research

Moderators: Ghost, Sonny

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PSSD Resources
by Ghost » Mon Jan 30, 2017 11:38 am

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Last post by siebs1122
Mon Jan 30, 2017 9:56 pm

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Thanks for doing this Ghost, it looks like a great start.
Forum Rules
by Ghost » Tue Nov 22, 2016 11:19 am

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Last post by Ghost
Tue Nov 22, 2016 11:19 am

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PSSD research looking for patients (Enrollment extended)
1 ... 8, 9, 10by Maldoror » Fri Jul 24, 2015 4:25 pm

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Last post by Delfador
Sat Apr 27, 2019 10:17 pm

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Any update on this?
PSSD Genome Project [Megathread]
1 ... 25, 26, 27by Ghost » Tue Apr 24, 2018 5:57 pm

261 Replies

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Last post by Ghost
Wed Apr 17, 2019 2:50 pm

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@Mesolimbo When using the charts remember that: C = RED G = GREEN A = BLUE T = BLACK Heterozygotes will be combinations of the above colors. 5HTTPLR allele - rs25531 (irrelevant on 23+Me apparently - all are called C/C) - rs25532: -- 4 SNPs for rs25532 analyzed for frequency -- CC: 0.0 CG: 0.0 GG:...
Participants wanted for PSSD study. Contact: sulawesi1@web.de
1 ... 30, 31, 32by sulawesi » Fri Feb 10, 2017 7:30 am

314 Replies

56931 Views

Last post by lw77
Thu Sep 13, 2018 11:22 am

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Guys but what happened to the study? Had it been done?
Ghost's Neuroscience Corner
1, 2by Ghost » Fri Sep 18, 2015 12:29 pm

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10575 Views

Last post by Ghost
Sun Jul 29, 2018 11:22 am

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I've moved my educational-type postings to my website.
How to Increase Arousal to the Opposite Sex [2019] How to Fall In Love Quicker with Supplements 2019
by Rb26dett » Sun Jun 16, 2019 11:46 pm

4 Replies

201 Views

Last post by JayR
Tue Jun 25, 2019 10:45 am

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Italy OK. 8-) 8-) 8-)
Antipsychotics, 5α-reductase inhibitors, SSRI’s, SNRI’s and TCA’s do all mess with neurosteroids!
by quagmire » Wed Apr 17, 2019 9:09 am

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Last post by quagmire
Mon Jun 17, 2019 2:40 pm

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As mentioned in the post above, SSRI's and also other antidepressants modulate brain steroids that has important roles in sexual function. Various antidepressants, including the SSRIs fluoxetine, fluvoxamine, sertraline, and paroxetine, the SNRI venlafaxine, and mirtazapine, have been found to...
Brain maps of SSRI induced gene expression changes
by Ghost » Sun Feb 08, 2015 7:40 pm

4 Replies

1993 Views

Last post by succubus76
Sun Jun 16, 2019 12:41 am

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No! In fact, there are a lot of people who criticize "oh Ghost and his crazy forum thinking you have epigenetic changes". This argument is BULLSHIT!!! You have epigenetic changes from diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants,...
Alpha:Beta activity in PSSD.
1, 2by JayR » Mon Jan 07, 2019 10:55 am

12 Replies

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Last post by JayR
Thu Jun 13, 2019 10:04 am

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@jayR what about being good enough and sharing ur pssd recovery if u rly had it? whats ur curently on? -yohimbe -prasozin -cialis -dextroamphetamine -metergoline u use these or none of this? sry but i look u as another internet prophet until u give the community something realistic and sincere...
New study reveals the epigenetic effects of Citalopram
1 ... 5, 6, 7by nasibi » Sat Oct 20, 2018 11:56 pm

63 Replies

11186 Views

Last post by AnhedonicApe
Mon Jun 10, 2019 10:23 am

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I am also thinking of adding sodium butyrate. Would that work similar to decitabine? No, not even close, but i may benefit u
Temperature and Heart Rate - Recent Discovery
1, 2, 3by apachuri » Sun Aug 30, 2015 10:45 am

20 Replies

3349 Views

Last post by custodyflagstaff
Thu May 30, 2019 4:01 am

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Although there's a wide range of normal, an unusually high or low heart rate may indicate an underlying problem. Consult your doctor if your resting heart rate is consistently above 100 beats a minute (tachycardia) or if you're not a trained athlete and your resting heart rate is below 60 beats a...
Androgen influence on prefrontal dopamine systems in adult male rats
by iull1k » Tue May 28, 2019 7:51 am

0 Replies

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Last post by iull1k
Tue May 28, 2019 7:51 am
found a pssd success story they didn't even know pssd existed
by Imtrying34 » Sat May 25, 2019 9:44 am

6 Replies

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Last post by Lusitanic
Sat May 25, 2019 2:26 pm

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Don't know... but the fact i spent 2 hours pretending i was being hypnotized...didn't help... it's highly overrated... like psychology in general. Do you think it can cure PSSD?please..
Galanin and its role in anhedonia(PSSD)?
by link11 » Wed May 22, 2019 10:52 am

2 Replies

294 Views

Last post by sopgirl
Thu May 23, 2019 6:41 pm

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Thanks for posting this Link11. It's very interesting.
Oxytocin Involvement in SSRI-Induced Delayed Ejaculation: A Review of Animal Studies
by lw77 » Mon May 20, 2019 3:06 am

5 Replies

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Last post by Moonwife
Mon May 20, 2019 9:00 pm

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Both me and been_too_long have discussed possible involvement of oxytocin in our readings from sexual health journals. But still at a loss how to connect the dots. One of thr glaring observations made by this study was how chronic use of SSRIs affect or cause sexual dysfunction. But what about...
Sleep deprivation and PSSD Symptoms - az89 OP
1, 2, 3by Ghost » Thu Feb 05, 2015 8:16 pm

28 Replies

6363 Views

Last post by succubus76
Wed May 15, 2019 11:38 pm

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I can also agree whit this
Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression
by iull1k » Thu May 02, 2019 5:17 am

5 Replies

1395 Views

Last post by ErgogenicHealth
Mon May 13, 2019 5:13 pm

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This can also be a link between Accutane, PFS, and PSSD. Accutane upregulates the presynaptic 5HT1A and SERT mRNA expression. This can cause drastically less activation of 5HT2A and downregulation of 5alpha-reductase mRNA expression. I've discovered recently that my type of PSSD is due to...
new pssd - lainfalco Intro
1, 2by lainfalco » Wed Mar 27, 2019 1:31 pm

18 Replies

2484 Views

Last post by sopgirl
Thu May 09, 2019 5:51 pm

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Does it cause PSSD (although it wouldn't be called that!) by itself or only worsen PSSD for those who already have it?
Elevated Prolactin
1 ... 6, 7, 8by Gameclay » Tue Jan 09, 2018 2:41 pm

79 Replies

14559 Views

Last post by sovietxrobot
Tue May 07, 2019 4:55 pm

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The experience you had with Ashawaghana is quite similar to what I had with Horny Goat Weed. Even just a few doses caused a noticeable worsening of all my symptoms. I've been taking Vitamin E and dopa mucuna to lower prolactin and raise dopamine, with some success. I feel stronger and have more...
Fluoxetine and gut microbiota
1, 2by Ciprofloxacin » Sat Mar 16, 2019 7:18 am

11 Replies

2412 Views

Last post by north4
Tue May 07, 2019 7:34 am
I healed pssd and ahendonia 80 percent success from numbness until adderal 5mg
1, 2, 3by Imtrying34 » Wed Oct 24, 2018 7:43 am

23 Replies

5892 Views

Last post by AnhedonicApe
Sun May 05, 2019 2:09 pm

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@geri Check your PM please. :) Any idea how this ended?
Serotonin - Androgen Receptor Correlation (BREAKTROUGH)
by iull1k » Sun Apr 14, 2019 1:16 am

7 Replies

1989 Views

Last post by PsychoGenesis
Thu May 02, 2019 11:13 am

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psychedelics may be useful
The Role of Microbiome in Insomnia, Circadian Disturbance and Depression
by TalkingAntColony » Mon Apr 29, 2019 6:01 am

0 Replies

935 Views

Last post by TalkingAntColony
Mon Apr 29, 2019 6:01 am
Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavio
by TalkingAntColony » Mon Apr 29, 2019 5:38 am

0 Replies

945 Views

Last post by TalkingAntColony
Mon Apr 29, 2019 5:38 am
Buspar (Buspirone)
1 ... 5, 6, 7by Ghost » Fri Aug 04, 2017 3:47 am

63 Replies

11436 Views

Last post by voyteck
Sun Apr 28, 2019 11:12 am

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My psychiatrist prescribed me BuSpar, just to treat PSSD. Anyone there have positive reports? I'm afraid to use it and make it worse I warn you against buspirone. Full story in my intro.
How does serotonin inhibit sexuality exactly?
1, 2by taarn » Fri Apr 19, 2019 6:24 am

11 Replies

2242 Views

Last post by taarn
Sat Apr 20, 2019 1:28 pm

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Any thoughts on Tianeptine? Ive read some contradictive stuff if it really decreases serotonin. First I also found Tianeptine as interesting but I've also read contradicting stuff. But finally I thought I won't be tinkering with it. If I remember well it enhances SERT binding but can decrease SERT...
Sexual response cycle (possible wiki)
by taarn » Sun Apr 14, 2019 2:00 pm

0 Replies

1562 Views

Last post by taarn
Sun Apr 14, 2019 2:00 pm
Effects of Psychotherapy on 5HT1A receptor density
by paramahamsa » Fri Aug 28, 2015 12:45 pm

3 Replies

4172 Views

Last post by Blueturtle
Wed Apr 03, 2019 3:36 pm

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This is really fascinating. The fact that psychological talk therapy could effect the very scary real physical symptoms like ejaculatory anhedonia and genital numbness. Interesting... perhaps this impilicates 5-HT1A more in the weak genital responses? Huh. This is a super old thread but it really...
another peanutsack intro
by PsychoGenesis » Sun Mar 31, 2019 2:54 pm

4 Replies

1659 Views

Last post by PsychoGenesis
Wed Apr 03, 2019 9:49 am

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i just got the strongest HIV coquetel available here should i take it now or will it interfere with the doxazosin?
Berberine
1 ... 8, 9, 10by Moloch » Sat Feb 07, 2015 4:29 am

93 Replies

19508 Views

Last post by TalkingAntColony
Mon Mar 11, 2019 3:09 pm

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Mrstaircase, Great update! Coukd you provide more details such as how you are cycling those things, dosages, and timeline of improvements?
Cortene drug trial/Astressin B
1, 2, 3by Maxin » Wed Feb 06, 2019 1:25 pm

21 Replies

3416 Views

Last post by Maxin
Wed Mar 06, 2019 10:17 pm

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I also believe that our chronic fatigue is a very helpful clue in what could be behind the causes of cfs/me. That it could be a problem in the serotonergic system. I think in the last few years they have realized that chasing viruses and focusing on immune system is not getting them where they...

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