PSSD Collaborative Research

A forum dedicated to collaborative research into PSSD (Post-SSRI Sexual Dysfunction).

PSSD related research

Moderators: Ghost, Sonny

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New Dr. Goldstein Research [YOUR HELP NEEDED!!!]
1, 2, 3by Ghost » Wed Oct 23, 2019 8:19 pm

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Last post by anacleta
Sat Dec 14, 2019 6:10 am

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Hi Ghost, I have some difficulties with English. You say we should call Goldstein (to present our case of PSSD, did I understand correctly?), isn't there an email address?
PSSD Resources
by Ghost » Mon Jan 30, 2017 11:38 am

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Last post by siebs1122
Mon Jan 30, 2017 9:56 pm

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Thanks for doing this Ghost, it looks like a great start.
Forum Rules
by Ghost » Tue Nov 22, 2016 11:19 am

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Last post by Ghost
Tue Nov 22, 2016 11:19 am

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PSSD research looking for patients (Enrollment extended)
1 ... 8, 9, 10by Maldoror » Fri Jul 24, 2015 4:25 pm

95 Replies

49775 Views

Last post by future-recovery
Sat Nov 30, 2019 2:48 pm

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Does anyone know when the study will be published?
PSSD Genome Project [Megathread]
1 ... 27, 28, 29by Ghost » Tue Apr 24, 2018 5:57 pm

284 Replies

252163 Views

Last post by sovietxrobot
Tue Oct 22, 2019 7:11 am

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Paper on the genetic effects of citalopram: Kanherkar et al. 2018. The effect of citalopram on genome-wide DNA methylation of human cells. International Journal of Genomics. In short: Human cell culture exposed to citalopram for a month. OXT gene downregulated, inhibition of dopa pathway. Coincides...
Participants wanted for PSSD study. Contact: sulawesi1@web.de
1 ... 30, 31, 32by sulawesi » Fri Feb 10, 2017 7:30 am

314 Replies

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Last post by lw77
Thu Sep 13, 2018 11:22 am

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Guys but what happened to the study? Had it been done?
Ghost's Neuroscience Corner
1, 2by Ghost » Fri Sep 18, 2015 12:29 pm

10 Replies

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Last post by Ghost
Sun Jul 29, 2018 11:22 am

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I've moved my educational-type postings to my website.
Berberine
1 ... 13, 14, 15by Moloch » Sat Feb 07, 2015 4:29 am

146 Replies

28504 Views

Last post by R3m3dy
Fri Jan 17, 2020 8:50 am

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I will be giving my final review on berberine/icariin following my next sexual encounter. I am entirely off both now but want to confirm one last thing before I give a final update. I do plan on running the combination again very shortly, although I may try St. John's Wort again and if I do I would...
Active DNA Demethylation in Post-Mitotic Neurons: A Reason for Optimism (PSSD TREATMENT?)
by ac3c » Thu Dec 19, 2019 11:56 am

1 Replies

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Last post by enriqueiglesias
Wed Jan 15, 2020 11:33 pm

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I think one can partly interpret this as saying that demethylation isn't necessarily such a big deal, if one uses DNMT1 and DNMT3 inhibitors, among other things. Compulsive negativity in this forum, assumed or "cherry-picked" from a minority of studies, notwithstanding. HDAC inhibitors,...
Progesterone
1 ... 22, 23, 24by Ghost » Mon Jul 24, 2017 12:46 am

231 Replies

41924 Views

Last post by SufferingfromSSRI
Tue Jan 14, 2020 1:26 pm

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the lab should offer a range Thank you! 0.0-0.5 is the stated range. I guess I didn't realize it can vary so much from lab to lab and 0.3 might be normal for one lab and high for another, etc. And I suppose I'm in the middle of the normal range IF this range is for men (there was no option).
Sexuality Research
by sraj » Wed Jan 08, 2020 7:07 am

2 Replies

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Last post by Jaxx
Wed Jan 08, 2020 9:49 am

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Hello everyone, I am currently working on research that examines the effects of PSSD in relation to both the physical sexual effects as well as the emotional sexual effects. There's a scarcity of research on how SSRI use can hamper thoughts about one's sexuality and sexual wellbeing overall. Any...
The epigenetic changes triggered by antidepressant intake and withdrawal
by ac3c » Thu Dec 19, 2019 11:48 am

2 Replies

524 Views

Last post by alteredhomeostasis
Sat Dec 21, 2019 9:20 am

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i wonder if doing a reinstatement while on high dose TRT would shift the demethylated/methylated gene profile towards a better one... This is a good idea. I’m pretty convinced that reinstatement of some sort is the only way back from this.
Buspar (Buspirone)
1 ... 5, 6, 7by Ghost » Fri Aug 04, 2017 3:47 am

64 Replies

13295 Views

Last post by squirtleSquirtle
Fri Dec 13, 2019 10:57 am

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My psychiatrist prescribed me BuSpar, just to treat PSSD. Anyone there have positive reports? I'm afraid to use it and make it worse I warn you against buspirone. Full story in my intro. Rest in peace my friend. I am very sad that this was one of your last posts. We will not forget you.
Tryptophan Depletion
1, 2by Ghost » Sun Oct 11, 2015 10:23 am

16 Replies

8801 Views

Last post by PsychoGenesis
Thu Dec 05, 2019 4:51 am

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or you can filter it here
World first as artificial neurons developed to cure chronic diseases 2019
by anacleta » Tue Dec 03, 2019 1:18 pm

0 Replies

351 Views

Last post by anacleta
Tue Dec 03, 2019 1:18 pm
New study reveals the epigenetic effects of Citalopram
1 ... 8, 9, 10by nasibi » Sat Oct 20, 2018 11:56 pm

91 Replies

16207 Views

Last post by ac3c
Thu Nov 28, 2019 9:02 am

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plz stop with nonsense plz What we need is counter arguments to why decitibine or valpro wouldn't work Plz people with medical knowledge theories here Decitibine is just too dangerous to test. The risk of collateral damage is huge. Hell, lets pretend we knew it would have an effect. The question...
Post-synaptic 5HT1A receptors inhibit NMDA and genital sensitivity?
1, 2by enriqueiglesias » Sun Sep 22, 2019 9:03 am

10 Replies

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Last post by sylv
Sun Nov 24, 2019 4:34 am

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What seems to "cure" me is a drug called Cyproheptadine (Periactin), which is a known serotonin antagonist. But the weird component is this. When I take 1mg of this drug, I will be sleepy (normal response) and wake up feeling tired. The following day I feel the same. BUT it's day 3 and 4...
Lesser-known tidbits on Bupropion
by Meso » Sat Nov 09, 2019 4:28 am

9 Replies

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Last post by PsychoGenesis
Sun Nov 10, 2019 2:00 pm

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4. this is why people report that agmatine prevent their tolerance to bupropion effects 5. may be why it increases the risk of psychosis
Antipsychotics, 5α-reductase inhibitors, SSRI’s, SNRI’s and TCA’s do all mess with neurosteroids!
by quagmire » Wed Apr 17, 2019 9:09 am

3 Replies

2340 Views

Last post by iull1k
Wed Oct 23, 2019 3:58 am

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Yeah you are right, but that's not new. This theory is seriously considered by propeciaforum admins.
Gotu Kola (Centella Asiatica) and Bacopa on GluR1, 2 and NR2A, B
by enriqueiglesias » Thu Aug 29, 2019 9:48 am

6 Replies

2132 Views

Last post by enriqueiglesias
Mon Oct 21, 2019 6:08 am

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Regarding dosage: it may not be limited to a low dosage, but standardized extract may work better over time (what I had tried first). Adverse reactions may come from immediate effect compared to waiting a bit. Or purity may make extract better. (Powder still works and is how it's mostly sold and...
Genital numbness/anesthesia: the science
by Meso » Sun Sep 29, 2019 4:38 am

7 Replies

1959 Views

Last post by ziran0
Tue Oct 08, 2019 8:06 am

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Hello Mesolimbo . I am new here. I get Mechanical numbness and Erogenous numbness from Escitalopram . I lost all my sexual pleasures. When my genitals being touched , i can hardly feel it , and it can not generate pleasure at all. When i am kissing or my perianal and prostate being touched i can...
FOUND THE CAUSE OF PSSD!!! SEROTONIN - PPARy - nNOS *REVEALED*
by JayR » Wed Aug 07, 2019 6:47 am

7 Replies

2116 Views

Last post by PsychoGenesis
Thu Oct 03, 2019 8:02 am

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must be easy to test with a PPARy agonist like pioglitazone PPARa agonist fenofibrate seems to have the opposite effect on AR in prostate cells if the same applies to penis tissue and going by this study on finasteride showing doubled AR expression in the penis may be that could reverse androgen...
SSRi-induced Parkinsonism
by sovietxrobot » Wed Sep 18, 2019 11:05 am

2 Replies

1670 Views

Last post by quagmire
Wed Sep 18, 2019 12:07 pm

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Pssd could be caused by inhibition of dopamine, and or lack of dopamine. Many with PSSD suffer from anhedonia (Anhedonia and sexual anhedonia). If you lower dopamine you will get anhedonia and could also suffer derealization/depersonalization symptoms and other dysphoric feelings. From wikipedia...
On sexual desire systems and loss of libido [Part 1]
1, 2by Meso » Tue Sep 17, 2019 5:52 am

16 Replies

2943 Views

Last post by sovietxrobot
Wed Sep 18, 2019 12:04 pm

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For example, you might write that if one takes cabergoline and experiences no improvement, then their XYZ pathway is probably functioning properly, therefore they should shift their focus to the ABC pathway, which they can evaluate by taking some other pharmaceutical. And so on until the problem is...
SSRI blocks Muscarinic acetylcholine receptors, could lead to sexual dysfunction
by quagmire » Wed Sep 18, 2019 5:37 am

2 Replies

1683 Views

Last post by finities infinities
Wed Sep 18, 2019 6:43 am

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Postsynaptic 5ht1a receptor decrease acetylcholine and glutamate in hippocampus- maybe is do you mean? Muscarinic receptor is antidopaminergic, muscarinic antagonist disinhibition dopamine.
GnRH/kisspeptin/nkb/GNIH
1, 2by kpavel » Fri Aug 16, 2019 7:57 am

10 Replies

1723 Views

Last post by finities infinities
Sat Sep 14, 2019 6:38 am

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Yes! I am in a relationship and I am successful. But the most important thing is to please myself, that's why my dream has always been to change my appearance to more narcissistic, agressive.
Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression
by iull1k » Thu May 02, 2019 5:17 am

7 Replies

2134 Views

Last post by fellow1
Sat Aug 31, 2019 1:03 am

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could anyone suggest presynaptic 5ht1a antagonist ?
L-Cysteine far better than Acetyl-Cysteine?
by enriqueiglesias » Tue Aug 27, 2019 3:21 pm

0 Replies

1623 Views

Last post by enriqueiglesias
Tue Aug 27, 2019 3:21 pm
On progesterone and allopregnanolone: effects on the central nervous system (CNS)
by Meso » Sun Jul 21, 2019 6:44 am

7 Replies

1272 Views

Last post by lukejimmy
Mon Aug 26, 2019 8:36 pm

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Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression. This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABAA receptor – moderate level increases (in the range of 1.5–2 nM/L total...
New review: on to dopamine phasic & tonic release [116 studies]
1, 2, 3by Meso » Tue Aug 06, 2019 5:31 am

23 Replies

2615 Views

Last post by finities infinities
Sat Aug 24, 2019 10:26 am

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Increasingly, I believe in your theories about: presynaptic 5ht1a supersensitivity or downregulation postsynaptic 5ht1a. Especially since: presynaptic 5ht1a = increase rem sleep postsynaptic 5ht1a = block rem sleep. I read your article and associated it with: tonic dopamine activation: creepy...
Transcriptional dysregulation of 5-HT1A autoreceptors
by iull1k » Wed Jul 25, 2018 11:33 pm

3 Replies

3177 Views

Last post by Tree
Mon Jul 29, 2019 2:34 pm

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Is there evidence to support over expression of GR induced by ssri?
PSSD - an infection blocks recovery ?
by north4 » Sun Jul 21, 2019 9:38 pm

3 Replies

883 Views

Last post by Maxin
Mon Jul 22, 2019 2:36 pm

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I’m going to be trialing truvada for this reason. A member on I believe propecia help cured his symptoms accidentally with truvada.
AD treatment, not depression, leads to reductions in behavioral and neural responses to pain empathy
by north4 » Wed Jul 17, 2019 2:33 am

1 Replies

727 Views

Last post by Gameclay
Wed Jul 17, 2019 7:57 am

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Good find. Fluoxetine has always given me emotional blunting. One of my best friends passed away at age 21 and I couldn't feel any true sadness about what had happened. I remember drinking half a bottle of alcohol just to feel some sort of sorrow. Luckily I can still feel a normal array of sadness...

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