tldr: it's a hormone which up/down-regulates genes and neurotransmitters lots of which are involved in PSSD > https://sci-hub.tw/https://onlinelibrar ... 09.00439.x
anyway i was reading about nandro's effect on DRN firing which intrigued me as SSRI's have the same impact>
"Selective Serotonin Reuptake Inhibitors (SSRIs)
SSRIs exert a relatively selective blockade of 5-HT transporter [289], progressively increasing 5-HT levels, also in the circulation [290, 291], and influencing the immune response in a dose-dependent manner [252]. As a consequence, long-term SSRI treatment desensitizes the inhibitory somatodendritic 5-HT1A autoreceptors in the dorsal and medial raphe, and 5-HT neurotransmission is enhanced [292-294]. Furthermore, a desensitization of 5-HT2A and 5-HT2C receptors occurs as a consequence of prolonged exposure to elevate levels of 5-HT [295, 296]. Finally, since 5-HT neurons exert a tonic inhibitory effect on locus coeruleus neurons, it appears that enhancing 5-HT neurotransmission by sustained SSRI administration leads to a reduction in the firing rate of noradrenergic neurons [35]. Thus, drug-mediated enhancement of 5-HT activity exerts immunostimulatory effects on Th1 cytokines [32], possibly acting on 5-HT1A receptors, and concomitant immunoinhibitory effects on Th2 cytokines. Furthermore, it has been proposed that long term SSRI treatment in depressed patients causes a decrease in circulating cortisol levels by reestablishing the down-regulated glucocorticoid receptor sensitivity [27], thus restoring negative feedback by cortisol on the HPA axis [297-299]. "
so this led me to search for a way to recover DRN firing, it's in clinical trial phase 3
http://media.corporate-ir.net/media_fil ... hl_5_3.pdf
for my purposes the best way to go is frontloading (hydroxy)bupropion 600mg on first day to prevent getting metabolism to DXO and then take 300mg bupropion / 120-240mg DXM per day
sigma agonism is a beautiful thing, reminds me the sober high you get from DMT microdosing which feels legitly like NZT from limitless
its really an awesome drug combination(even among the less legal ones)
