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Unread postPosted: Sun Apr 08, 2018 9:46 pm
by Dark0047
Hello all. I hope you're doing OK. So I ordered some Ashwagandha off the Amazon but I am worried to try it since I read something on the web. I just need your thoughts. Here's what it is written about it.
"Ashwagandha also DECREASES the sensitivity of serotonin 5-HT1A-receptors...(8) this may lead to increased serotonin activity at the type 2 serotonin receptors - leading to a host of pathological changes. The decrease in 5-HT1A reactivity may improve OCD by yet again, lessening serotonin's inhibitory influence on glutamate and increasing glutamatergic activity(9)."
Does it make PSSD worse or better?

Re: Is Ashwagandha good for PSSD?

Unread postPosted: Sun Apr 08, 2018 10:19 pm
by Ghost
There are some other places that the herb has been mentioned on the forum. Becuase I have tried it before and think it's a good option, I am surprised it doesn't have a thread yet. This will become the official thread. I may merge in some older stuff at some later date.

Re: Ashwagandha

Unread postPosted: Sun Apr 08, 2018 11:36 pm
by Ghost

Ashwagandha PSSD?

Unread postPosted: Tue Aug 07, 2018 5:32 am
by DGard
Hey, all

I took high dose or powdered ashwaghanda root. for about 5 weeks

Anywhere from 7-14 grams a day. I know it a lot.

I was completely sedated and I like dit, problem it after being off it I am still sedated and have feelings of anhedonia. I also have genital anesthesia. It the pleasurable feeling of orgasm as well.

I've been off it for 12 days now and I feel a little better sometimes but yesterday I had a high carb meal after a high protein meal and all the symptoms came back.

I wonder is it due to the Ash increasing the activity of the autoreceptors and decreasing the activity of the post synaptic receptors?

This is the study I refer to

Is there anything I can do to reverse this?

Thank you

Re: Ashwagandha PSSD?

Unread postPosted: Tue Aug 07, 2018 2:14 pm
by Jaxx
Buddy, first you open a year old topic and then ask this question in a seperate topic. Please adress this topic in one of the many relevant threads.
Sorry but the forum is getting too messy otherwise.


Unread postPosted: Sat May 11, 2019 6:27 pm
by scept
Since anxiety/OCD can be an issue for some of us (on top of the PSSD), I figured I'd try and help my ongoing OCD that I have.

I've been taking KSM-66 ashwagandha (300mg a day) for the last 10-13 days or so, mostly for anxiety/OCD. The first 7-10 days I noticed a HUGE improvement in my OCD, probably an 80% reduction, it mostly made me handle my thoughts a lot better. Over the last few days it seems that it's not working as well anymore, and I've noticed myself having more thoughts and compulsions. It could honestly be my brutal schedule from school lately, but I'm not sure. Should I discontinue the ashwagandha? I know it's a GABA agonist and some people think it should be cycled, or is there no reason to cycle it?

Re: ashwagandha

Unread postPosted: Sun May 12, 2019 1:33 pm
by Ghost
topic merged.

Re: Ashwagandha

Unread postPosted: Wed Sep 11, 2019 5:00 am
by Janie
Ghost or anyone, do you think ashwagandha is safe for sleep issues with pssd? I think I have too high cortisol at evening. Haven't tested it. Not in extreme, just in normal doses of course. Any other recommendation for sleep?

Re: Ashwagandha

Unread postPosted: Wed Sep 11, 2019 11:27 am
by AnhedonicApe
Some people have reported GETTING pssd from Ashwaganda

Re: Ashwagandha

Unread postPosted: Thu Sep 12, 2019 7:20 am
by enriqueiglesias
I use Sodium Butyrate as an effective counter-measure to Ashwagandha. At times I wasn't sure which I prefer though, as the whole matter, especially Ashwagandha, is lacking some elucidation. Ashwagandha is often mentioned in contexts where it would seem contradictory, without further explanation, just because "it's safe" or "well tolerated". I am now very much leaning towards Sodium Butyrate though. It increases 5HT1A receptors, but seemingly in a good way (I guess autoreceptor control).

Edit: I'm still not sure, however... I think the right result is somewhere inbetween.
Edit2: Tried mostly Ashwagandha again, and it definitely caused all-around anhedonia symptoms and less libido, although it made me calmer. I doubt this was caused by anything else, as the effect and correlation was quite strong. A small dose of Sodium Butyrate did improve me overall, I think. I think Sodium Butyrate is better against depression, and lack of motivation, anyway, however sometimes I'm just not sure if that's also the path for improved libido.