https://www.ncbi.nlm.nih.gov/pmc/articl ... o=0.602410
As I understood, it says that absence of 5a-red(2) expression causes hypermethylation of it’s promoter gene, by increasing inflammatory cytokines. Thereby it reduces 5a reductase activity. Also it says that 5a-R is reactivated with tnf-a inhibitors. I couldn’t read that well in that situation, so it is good to someone look it.
I have looked up to selfhacked and found pretty related things with our problems. Even more logical than neurosteroid theory according to my symptoms.They are really, interestingly related and must be looked up imo.
https://www.selfhacked.com/blog/supplem ... in-6-il-6/
The bad thing, I have found that it also answers to my question. Why am I worsening by time? As papers say, Excess TNF-Alpha levels are toxic to the brain and causes neuron(dopaminergic) loss. When it happens in substantia nigra, you have get parkinson. I got akinesia from pssd.
https://www.ncbi.nlm.nih.gov/m/pubmed/19969084/
It says irreversible. Oh god, no.
