PSSD Collaborative Research

by **AdvencedResearchPL** » Mon May 20, 2019 8:45 am

I do not know if this is very important but I decided to put it on the forum. Maybe someone can find some analogy in this.

CPA is used as an antiandrogen and form of chemical castration in the treatment of paraphilias and hypersexuality in men.[90][91][92][93][94][95] It is used to treat sex offenders. The medication is approved in more than 20 countries for this indication and is predominantly employed in Canada, Europe, and the Middle East.[96] CPA works by decreasing sex drive and sexual arousal and producing sexual dysfunction. CPA can also be used to reduce sex drive in individuals with inappropriate sexual behaviors, such as people with intellectual disability and dementia.[97][98] The medication is also useful for treating self-harmful sexual behavior, such as masochism.[99] CPA has comparable effectiveness to medroxyprogesterone acetate in suppressing sexual urges and function but appears to be less effective than GnRH modulators like leuprorelin and has more side effects.[91]

High-dose CPA significantly decreases sexual fantasies and sexual activity in 80 to 90% of men with paraphilias.[96] In addition, it has been found to decrease the rate of reoffending in sex offenders from 85% to 6%, with most of the reoffenses being committed by individuals who did not follow their CPA treatment prescription.[96] It has been reported that in 80% of cases, 100 mg/day CPA is adequate to achieve the desired reduction of sexuality, whereas in the remaining 20% of cases, 200 mg/day is sufficient.[100] When only a partial reduction in sexuality is desired, 50 mg/day CPA can be useful.[100] Reduced sexual desire and erectile function occurs with CPA by the end of the first week of treatment, and becomes maximal within three to four weeks.[100][88] The dosage range is 50 to 300 mg/day
https://en.wikipedia.org/wiki/Cyproterone_acetate#Chemical_castration