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AD replacement for PSSD

General discussions. Feel free to use this like a support group also.

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First unread post • 3 posts • Page 1 of 1

AD replacement for PSSD

Unread postby PsychoGenesis » Thu Sep 26, 2019 8:24 am

whats up people i have finished my trial with nandrolone without much improvement(yet)
tldr: it's a hormone which up/down-regulates genes and neurotransmitters lots of which are involved in PSSD > https://sci-hub.tw/https://onlinelibrar ... 09.00439.x


anyway i was reading about nandro's effect on DRN firing which intrigued me as SSRI's have the same impact>

"Selective Serotonin Reuptake Inhibitors (SSRIs)

SSRIs exert a relatively selective blockade of 5-HT transporter [289], progressively increasing 5-HT levels, also in the circulation [290, 291], and influencing the immune response in a dose-dependent manner [252]. As a consequence, long-term SSRI treatment desensitizes the inhibitory somatodendritic 5-HT1A autoreceptors in the dorsal and medial raphe, and 5-HT neurotransmission is enhanced [292-294]. Furthermore, a desensitization of 5-HT2A and 5-HT2C receptors occurs as a consequence of prolonged exposure to elevate levels of 5-HT [295, 296]. Finally, since 5-HT neurons exert a tonic inhibitory effect on locus coeruleus neurons, it appears that enhancing 5-HT neurotransmission by sustained SSRI administration leads to a reduction in the firing rate of noradrenergic neurons [35]. Thus, drug-mediated enhancement of 5-HT activity exerts immunostimulatory effects on Th1 cytokines [32], possibly acting on 5-HT1A receptors, and concomitant immunoinhibitory effects on Th2 cytokines. Furthermore, it has been proposed that long term SSRI treatment in depressed patients causes a decrease in circulating cortisol levels by reestablishing the down-regulated glucocorticoid receptor sensitivity [27], thus restoring negative feedback by cortisol on the HPA axis [297-299]. "



so this led me to search for a way to recover DRN firing, it's in clinical trial phase 3

http://media.corporate-ir.net/media_fil ... hl_5_3.pdf

for my purposes the best way to go is frontloading (hydroxy)bupropion 600mg on first day to prevent getting metabolism to DXO and then take 300mg bupropion / 120-240mg DXM per day


sigma agonism is a beautiful thing, reminds me the sober high you get from DMT microdosing which feels legitly like NZT from limitless

its really an awesome drug combination(even among the less legal ones)
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Re: AD replacement for PSSD

Unread postby Meso » Sat Sep 28, 2019 5:42 am

I also suspected that sigma agonism is why I react more favorably to Donepezil than Rivastigmine. The former is a potent sigma agonist.

I've had my fair share of trialing closed-channel (memantine, amantadine) and opened-channel (methoxetamine, dextromethorphan) NMDA antagonists. I have to say that long-term intake of MXE/DXM can screw up one's cognitive abilities too much, even at low doses.

That said, I have low glutamate to begin with, so your mileage may vary.
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Re: AD replacement for PSSD

Unread postby PsychoGenesis » Sat Sep 28, 2019 7:50 am

Mesolimbo wrote:I also suspected that sigma agonism is why I react more favorably to Donepezil than Rivastigmine. The former is a potent sigma agonist.

I've had my fair share of trialing closed-channel (memantine, amantadine) and opened-channel (methoxetamine, dextromethorphan) NMDA antagonists. I have to say that long-term intake of MXE/DXM can screw up one's cognitive abilities too much, even at low doses.

That said, I have low glutamate to begin with, so your mileage may vary.


yeah me too, love memantine beside the decrease in libido
this combination is not dissociative like dxm alone and feels like it improves working memory, episodic memory
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