A forum dedicated to collaborative research into PSSD (Post-SSRI Sexual Dysfunction).
Is it going to work? what if it worsen my symptoms?
PLZNO wrote:Those are what I have right now.. "Orgasms are explosive, penis is sensitive again, and exercise feels fantastic."
What I need is getting my sexuality back
jaiho wrote:SSRIs are not inherently bad... They cause sexual dysfunction via activation of 5HT1A, 5HT2A & 5HT2C.
siebs1122 wrote:...I recently read a thread on another website where someone was permanently cured with Clomipramine, which is a 2A/2C antagonist. If you're thinking about going back on an SSRI, this might be the one to try.
fablecloth wrote:Ghost wrote:I've taken [Trazodone] at 50mg for sleep a handful of nights last year. Never did a ton for PSSD if I can recall.
There used to be a user named Gonzo who had erections recovered on [Trazodone], and it lasted 5 months after he stopped. I don't think he ever made the transition to the new site, however.
Your lack of response may have been due to too low a dose. Check out this article by Stahl (http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.605.7477&rep=rep1&type=pdf) on Trazodone as an effective SARI, and how doses of 150-600MG are required to inhibit SERT (there is a diagram of its relative binding affinities at various doses). At lower doses, Trazodone is just a hypnotic, and is indeed prescribed off-label for this very purpose, at low doses.
Also check out the table 'Possible Functions of Postsynaptic Serotonin Receptors' on page 538. Stahl refers to the 5HT2A and 5HT2C receptors as regulating sexual function. Trazodone at sufficiently high doses is a 5HT2A and 5HT2C antagonist, which apparently eradicates sexual side effects. This is contrary to normal SSRIs, which engage those receptors and thus cause sexual side effects. Stahl indicates that the 5HT1A receptor is not involved with sexual dysfunction, and thus elevates serotonin levels without the nasty side effects.
I find this quite curious. I have experience, having tried MAOIs like Nardil and Parnate, that practitioners are far too conservative when it comes to dosing regimes, and lack of therapeutic efficacy can often be attributed to inadequate dosing.
I am keen to try the XR version of Trazodone (Oleptro), which theoretically allows for elevated (i.e. therapeutic) levels of trazodone in the body, without rapid influxes due to multiple daily dosings, which exacerbate the sedative effects. Frustratingly, Oleptro is currently under patent and costs a fortune. But it's worth a shot. I live in Australia and whilst Trazodone isn't sold in Australia, it is legal to import certain prescription drugs for private use. Trazodone is on the list of allowable drugs.
I'm trialling St John's Wort at the moment (Kira, having switched from Perika), but will in a couple of months look for a reputable international pharmacy that would supply with a valid Australian prescription.