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SSRI's and the gut

Unread postPosted: Thu Dec 29, 2016 11:54 am
by Dead
In recent years there has been a lot of talk about the gut flora and it's relation to our health. It has been linked to conditions like depression, autism and various mood disorders. IIRC about 90% of the serotonin in our bodies is in our gut. Does anyone know if SSRI's affects this? Could SSRI use be causing long term or permanent changes to our gut floras?

I recently did an experiment with probiotics, where i did daily probiotic enemas for four days. The reason i did it was to combat my IBS but the result affected my mind more than anything. For almost ten days following i had so much more energy, and i was masturbating like crazy everyday. And my mind was so much clearer, i even enjoyed socializing. And more than anything my mood was elevated. Basically i haven't felt so normal since i got this condition. Now the effects have worn off again, and i'm exactly as i was before. Very slow and apathetic, like a zombie. And my libido is gone, can't even get an erection.
Anyway, this probably won't be a popular opinion, but i'm thinking that maybe we have been targeting the wrong organ? Maybe it's our gut floras that have become messed up, and not our brains?

Re: SSRI's and the gut

Unread postPosted: Thu Dec 29, 2016 12:13 pm
by PLZNO
Another supplement to try...

I'm really sorry about this question
But are you sure that your libido has improved?

Re: SSRI's and the gut

Unread postPosted: Thu Dec 29, 2016 12:55 pm
by Dead
Yes it did absolutely, but now it's just as gone... I'm gonna do another try at this in the near future with stronger/more probiotics.
Btw, if you wanna give this a shot i don't recommend that you take them by mouth because it seems that most of them will die from the gastric juice before reaching the colon. I recommend you take them by enema actually. As mentioned before i originally did it to try to treat/cure my IBS. I came upon this thread on reddit where a doctor had been doing this procedure on IBS patients with good cure rates. Here it is: https://www.reddit.com/r/ibs/comments/2 ... d_it_work/

Re: SSRI's and the gut

Unread postPosted: Thu Dec 29, 2016 1:08 pm
by PLZNO
I'm not an IBS patient... Is there an enema shot? where can I get one without prescription? putting an oral pill into my anus is probably going to work? :lol:

Re: SSRI's and the gut

Unread postPosted: Fri Dec 30, 2016 6:18 am
by marsupial
Do you have more info about probiotics you took? The least what we can try is to take probiotics orally, proper coated pill it should reach gut just fine. And you can take it regulrly. It may be a coincidence though. I think that the windows we have in PSSD is like regular libido fluctuation it just sometomies get so high that its noticable over PSSD. I got pretty nice sexual functions over christmas for example. It is great that we keep trying. I just started with nystatin and I plan to take ephedrine once or twice

Re: SSRI's and the gut

Unread postPosted: Fri Dec 30, 2016 6:41 am
by Angrydude00
Be careful about the whole "leaky gut" phenomenon that swept Holistic medicine a few years ago. Much of it was debunked and many scam doctors were using this pseudo science to sell "detox" supplements to people with serious illness. The gut is typically completely capable of healing without the help of supplements or medication besides rare genetic cases. But who knows, I'll look into probiotics anyway.

Re: SSRI's and the gut

Unread postPosted: Fri Dec 30, 2016 12:01 pm
by Dead
@Angrydude00
I'm not talking about "leaky gut" though. The gut flora isn't pseudo science. But it's something that has just recently gotten attention in the scientific community. Over 90% of all articles about it on Pubmed where published in the last 5 years.
Take a look at this one for example:
"The Gut-Brain Axis: The Missing Link in Depression"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662178/

An extract:
"Based on evidence, the gut microbiota is associated with metabolic disorders such as obesity, diabetes mellitus and neuropsychiatric disorders such as schizophrenia, autistic disorders, anxiety disorders and major depressive disorders."
And another:
"Gut microorganisms are capable of producing and delivering neuroactive substances such as serotonin and gamma-aminobutyric acid, which act on the gut-brain axis. Preclinical research in rodents suggested that certain probiotics have antidepressant and anxiolytic activities."

There are tons of articles like that about the gut flora.

@PLZNO
You could buy something called a fleet enema, or you could just google diy enema.

@Marsupial
It was a bit stronger than most i commercial ones i believe, containing 7 strains of Lactobacillus and bifidobacterium and 15 billion bacterias per pill. But just make sure you get one with at least 4-5 different strains.

Re: SSRI's and the gut

Unread postPosted: Fri Dec 30, 2016 1:13 pm
by Marksanchez397
marsupial wrote:Do you have more info about probiotics you took? The least what we can try is to take probiotics orally, proper coated pill it should reach gut just fine. And you can take it regulrly. It may be a coincidence though. I think that the windows we have in PSSD is like regular libido fluctuation it just sometomies get so high that its noticable over PSSD. I got pretty nice sexual functions over christmas for example. It is great that we keep trying. I just started with nystatin and I plan to take ephedrine once or twice

Did you have nice sexual function on Christmas? Do you think it was due to nistatine?

Re: SSRI's and the gut

Unread postPosted: Sat Dec 31, 2016 2:36 am
by marsupial
Yes suddanly my sexual urges got back. But not due to nystatin. I started taking nystatin after my PSSD returned :( . After 2 days no effect. I will take it longer and maybe increase the doseage