Page 1 of 1

Trazedy intro - PSSD after Trazodone

Unread postPosted: Fri Mar 29, 2019 8:28 am
by Trazedy
Hi guys!
I'm an Italian student of psychology (sub-path in neuroscience), male 25yo.

HAVING PSSD FOR 6 MONTHS DUE TO TRAZODONE

This is not a "I was depressed, I took an SSRI, I have a PSSD"-story.
This is a "I'm one of the unluckiest person on planet earth"-story.

There will seem to be a lot of off-topic elements in this report but they will eventually make sense at the end. It's an extremely complicated and long story but if I don't speak with someone who can understand me and empatize, I go nuts. People keep minimizing my problems as they always did.


I always have had light IBS symptoms. On Spring 2011 I started to have diarrea 20 times a day, I lost 8kg in a month and I was literally dying in agony. 10 doctors, 2 gastroscopy, 2 colonscopy, 1 MR enterografy, 1 x-rays scan, blood tests, fecal tests, urine tests... I was "fine" and doctors told me it was "all in my head" and "not to think about it".

My life started falling into pieces, everyday was worse than the previous, the pain and the cramps were unbearable. I would have traded my illness with cancer, I would have loved to have 6 months without pain and than die fast. But I kept suffering. They gave me a special permit to go freely in and out of high school in order to finish my last year. I couln't go out and have friends and eat anything anymore. My days were literally shit from the moment I woke up to when I went to sleep.

After 1.5y, on Summer 2012, I went to a new doctor, and after two minutes he looked me in the eyes and sayd: "I know what you have, you have the SIBO syndrome. Do this test!". I did a breath test to measure the reaction to Lactulose and I was so ill that I was positive even before the lactulose ingestion. They gave me Rifaximin pills that did not cure me but did allowed me not to die. Now I had diarrea "just" 5-6 times a day and I could go to university.

Obviously I could not stand that life for long so I developed social anxiety, general anxiety, agoraphobia, insomnia, OCD... you name it. I stayed closed in my room for 10 months, I only went out once a month to buy food.

On Summer 2014 I went to a psychiatrist who gave my Paroxetine 20mg 20 drops a day. This was not intended to treat the mental problems (that were a consequence to the situation) but to treat my gut. I took it for 6 months without noticing any improvment or any side effect. At the same time of my first SSRI I got my first GF and we were having a lot of sex, I lasted enough, the libido was high... I can not say if the SSRI changed anything because the two thing started in the same months. I gradually quitted the Paroxetine on my own at the end of 2014. Now that I think about it, maybe I started to last a little bit less after the discontinuation but I didn't care. Sex was still awesome.

On 2015 I started psychotherapy and eating slightly better. On 2016 after 5ys (age 17-22) the SIBO syndrome start to improve. I felt better, I started to go out again. It was a slow process but I was happy.

At the same time I got an epididymitis on my left testicle. I had had it in my teens a couple of times and it eventually went away after a month. But at this point of the story I was a "free elf" for the first time in years, I had a girlfriend, I had to make up for lost time in university, for lost time with friend, I was busy.

I did not gave enouth importance to my epididymitis. On January 2017, after 6 fucking months I realized it was not going to heal by its own and I went to a "friend of a friend" busy urologist. He told me I had varicocele and that was the cause of the epididymitis, the cure should have been to surgically remove it ASAP.

Other months passed and on September 2017 I started to try to contact the busy urologist and I find out this fucking moron had forgotten to enroll me to the operation. On the end of October 2017 the inflammation was at its peak, I could not walk or have sex anymore. They operated me without addressing the inflammation first. I had not seen a doctor or take any pill in 10 months.

The operation on the ball (that should have not been operated while inflammed) went well but I got first a bad orchytis, then a stronger epididymitis, then an hydrocele. I should have been fine in a week, instead I was worst then ever untill February 2018, after 4 months no sign of iprovement.

At this point I started to get depressed for the first time in my life, all those years of suffering had depleted my resilience. Of course I had to abandon the university again because I could not walk or sit properly. I felt lost. I needed money so when I felt a little bit better started to work as a pizza maker even if I didn't feel like it. I was very anxious and insomniac. I tried with melatonin but it didn't work (Btw, I recently found out that it works with me but the dose was too low since in Italy they just sell it up to 1mg and they pretend it's enough in order not to pay the rights to Circadin® that patented the 2mg version. If I knew it at the time, my life would be different.)

Since I totally needed to sleep, I went to another psychiatrist and he prescribed me Olanzapine off-label for stress. I bought it, i cutted the pill in half and... I got scared. Google scared me even more by saying it could cause permanent changes in the brain, so I left it on the table. I stared at it for a week and then I throwed it away. I started to meditate and I was sleeping better. "Fuck pills and psychiatrists, I can do it on my own!" I sayd to myself. And it was true. I start learning about PSSD for the first time thanks to this forum.

It works for a couple of weeks but then my epididymitis star hurting more so on June 2018 I went to another urologist. He gave me Prednisolone 25mg for 20 days in order to cure the inflammation (spoiler alert: it didn't work). In those days I slept something like 1-2hours per night while stille working. The day I stopped the pills I got a strange crisis, I felt extremely cold even if it was summer and I had a duvet on me, I was shaking...

Since the day I stopped I started to wake up at 7am without any reason, even if due to my pizza maker job I had to sleep late in the night. In the morning, after the unexplainable waking up I couln't get back to sleep and I was anxious as fuck. I had always a headache so I went to the oculist since in the previous month I had noticed that my sight was worsening. They found I'm astigmatic so I order my first pair of glasses hoping that my headache would soon go away. (a week ago, after 9 months it turned out the shop gave me the wrong lens and I have been all this time with the wrong glasses, so my headache not only did not pass but it worsened ever since!)

On July 2018, thanks to my studying in neuroscience I start thinking that the cortisone pill disturbed my cortisol cycle so I menage to get a coltisol test prescription but I have no time to do it because I'm leaving for my 2 weeks of vacation with my GF.

Maybe in these 2 week of vacation I can relax and my sleep and headache is going to get better, right?
Nope. My GF left me after 4.5ys and I'm stuck with her both during the vacation and after it since we lived together.

So now its the end of August 2018, I have a severe sleep disorder, a strong hurting epididymitis, I'm wearing a wrong pair of glasses, I'm working in front of a wood oven 6 days a week untill late night during the Italian summer, my GF just left me and am also stuck with her everyday untill we both move out. What could possibly go wrong?

I start loosing my mind. I don't have the time for the cortisol testing, I need an immediate solution because I want to die and I spend my days crying and working with no sleep. My psychologist reassure me about permanent damage from drugs and advise me to see a psychiarist, so I go to a third psychiatrist who want to give me Paroxetine. I told her I had already taken it several years ago without any result and she prescribed me Venlaflazine 75. I can't resist taking it. I also took 4-5 pills of Samyr® (S-adenosyl-L-methionine) but stopped due to headache

We are on September 2018, since the first pills of Effexor® I get some sort ED and I need like 1 hour to orgasm. My mental health get also worse. I take it for 7 days, then I freake out, call the psychiatrist who reassure me about the sexual effect and tells me that there are only 2 sexually safe drugs: Trazodone and Wellbutrin. The way she talked seemed like if they were interchangeable (wtf, how could they be? One acts on serotonin, the other on dopamine. I didn't know these the drugs at the time.) So she advise me on the phone to get Trazodone that should help me with sleep.

I stop taking the Venlaflaxine and the sexual problems disappear right after. On the same day, during the free 15 minutes I have between my crying spells in the bed and my job, i search on Google "Trittico PSSD" (the Italian brand name for Trazodone) but I seem to find nothing usefull. Maybe it is really a PSSD-free drug.

If I were less out of my mind I would have searched for the word "Trazodone" instead of "Trittico" and I would have found the evidence I needed (The posts by @Trazohell and other reviews on Drugs.com). Or I could keep looking the other results for "Trittico" for 5 more minutes and I would have found something anyway, but on the 3rd result page. But I was stupid and in a hurry.

I took Trazodone 75mg that same night and I got the best sleep of my entire life, 12+hour with something like 15 different long dreams. In one of these I experienced an Astral Projection crosswise Saturn's Moons and I landed on a secret Nazi civilization that managed to escape WWII. In another one I travelled across my neurons and found buried memories of my childhood. It was one of the best experiences of my life. After some day it wasn't helping with my sleep anymore so I call the psychiatrist asking for an higher dose but she dissuaded me. Then days passed and I started noticing something strange. My dick looked shrinked and a little bit white, especially on the gland, as if there was not enough blood in it.

Since I could never have imagined it was something possible I reassured myself thinking it was just subgestion and stress. I googled "Penis shrinking" and I only found a paranoid syndrome with a Japanese name for people with axiety who believe their penis is disappearing. So I believed it could not happen. I kept jerking off once everyday just to check and it seemed to work but with some difficulty.

But after 25 days of the thruth was too obvious and I can not deny it anymore. My penis WAS shrinked, like a child's dick and my gland was too white.

I freaked out as never before. I searched the net in depth and finally I was able to find the reports by @Trazohell and other people. Penis shrinkage seemed to be reported on different forums by people after taking antipsychotic drugs.

PANIC.

I called right after the psychiatrist and the urologist and they both denied it was possible for a dick to shrink. So I went nuts and I abruptly stopped Trazodone after 28 days. The first 3 days were kinda bearable. I also got an extremely bad viral flu with fever and pain everywhere, other people around me had had it.

On the forth day of cold turkey+flu, It happened. That's when the withdrawal hit me. I had the worst headache of my life, I cried for a week almost 24/7, I couldn't sleep, I had nightmares, I had a lot of sweat and chills... and of course I lost my job, I could'nt function anymore.

So, on October 2018 I went back to my parent's and I spent a month like a retarded person, I sitted for hours doing nothing, I stared at the wall... If I wasn't crying I wasn't there. My mind went offline. After four weeks the headache diminuished and I could think again. The shrinking and the whiteness disappeared and some feeble erection came back but I still had light ED + numbness + anorgasmia. My urologist did not believe me and said that it was not my prolactin. I checked it anyway and it was high, 22,4 ngr/ml (range: 2,1-17,7).

I tried to reassure myself that when my prolactin lowered I could feel again. It did not happened.

Now, on almost April 2019, my prolactin is 12,8 but I still have light ED + medium/strong numbness + medium/strong anorgasmia.
I also still have epididymitis. I used to have a chronic sexual problem, now I have 2 of them + a sleep issue possibly related to cortisol. So I feel pain on my testicle when I walk, run, sit and make efforts. During sex it used to be a mixture of pain-discomfort + pleasure, now the pleasure is gone. BTW my GF is still with me and we are about to reach 5ys together but my emotion and my sexual feeling are fucked up. Dunno what's going to happen.

I'm in my 6th month of PSSD and 3rd year of epididymitis. I've been in dark places in the past few days after the prolactin results, because now I can not force myself to believe it is an hormonal easy fix. The worse part is that people keep denying my problem and I'm oversensitive to this attitude due to my history with the SIBO syndrome denial, so I decided to interrupt my lurking on the forum and come to say Hi.

TL;DR
1) I overcame an uncurable chronic problem and now I have other two of them.
2) 28 pills of Trazodone taken 7 months ago gave me PSSD. Trazodone is a SARI (serotonin agonist + SSRI), so it can totally cause PSSD. Other than that, it has a random effect that changes due to dose intake and wether or not your body metabolized it into the dangerous m-CPP. It is known for not causing PSSD only because it is an old drug not widely used. It's just statistics, not safeness. There is no safe drug.

Re: Trazedy intro - PSSD after Trazodone

Unread postPosted: Fri Mar 29, 2019 9:05 am
by Snake
You're story is just... stunning, yet so sad. It was like reading a good book. I'll tell you something, you're a tough motherf***. You'll overcome PSSD. It's shitty condition, but I believe it's fixable if some f*cks would stop denying it.

Re: Trazedy intro - PSSD after Trazodone

Unread postPosted: Fri Mar 29, 2019 9:22 am
by Trazedy
Snake wrote:You're story is just... stunning, yet so sad. It was like reading a good book. I'll tell you something, you're a tough motherf***. You'll overcome PSSD. It's shitty condition, but I believe it's fixable if some f*cks would stop denying it.


Thanks man! I can guarantee you that I will not stay quiet waiting. I know psychologists, I know peoples... we need time but we don't lack it.

Re: Trazedy intro - PSSD after Trazodone

Unread postPosted: Fri Mar 29, 2019 10:51 am
by Yellow99
Hey, I can totally understand how you feel. I also had a lot of health problems already before pssd and people Never wanted to believe me or said I shouldnt make such drama and yeah now with pssd everything is 1000x worse than I could have ever imaginged. I can not really give you tips as I‘m still in the beginning.. I started to see life as a fight since I have pssd.. just make it through day by day..

I also have pain in my genitals.. do you maybe know what causes this? For me it also gets more horrible when I move or touch down there or after sex. It makes me go crazy cause Even in normal Daily situations I can not forget a second about pssd cause it hurts the whole fucking time

Life is so much worse than what ist used to be before pssd but there are still moments where I can feel a Little Bit of joy.. just live for those moments

Re: Trazedy intro - PSSD after Trazodone

Unread postPosted: Fri Mar 29, 2019 11:25 am
by Trazedy
Yellow99 wrote:I also have pain in my genitals.. do you maybe know what causes this?


It depends. Is your pain a consequence of PSSD or is it unrelated? What part is hurting exactly?

Re: Trazedy intro - PSSD after Trazodone

Unread postPosted: Fri Mar 29, 2019 1:46 pm
by afx
Yellow99 wrote:Hey, I can totally understand how you feel. I also had a lot of health problems already before pssd and people Never wanted to believe me or said I shouldnt make such drama and yeah now with pssd everything is 1000x worse than I could have ever imaginged. I can not really give you tips as I‘m still in the beginning.. I started to see life as a fight since I have pssd.. just make it through day by day..

I also have pain in my genitals.. do you maybe know what causes this? For me it also gets more horrible when I move or touch down there or after sex. It makes me go crazy cause Even in normal Daily situations I can not forget a second about pssd cause it hurts the whole fucking time

Life is so much worse than what ist used to be before pssd but there are still moments where I can feel a Little Bit of joy.. just live for those moments

Yellow, please, go through a comprehensive medical evaluation with neurologists and do not give up if the first doctor will not find the cause, go see another specialist for another opinion. Get some MRIs. My strong belief is that something truly neurological may be the problem in Your specific case, such pain is really not likely from PSSD. Trazedys genital pain is also not PSSD related

Trazedy - stay strong bro, its gonna get better

Re: Trazedy intro - PSSD after Trazodone

Unread postPosted: Fri Mar 29, 2019 2:28 pm
by taarn
Yellow99 wrote:Hey, I can totally understand how you feel. I also had a lot of health problems already before pssd and people Never wanted to believe me or said I shouldnt make such drama and yeah now with pssd everything is 1000x worse than I could have ever imaginged. I can not really give you tips as I‘m still in the beginning.. I started to see life as a fight since I have pssd.. just make it through day by day..

I also have pain in my genitals.. do you maybe know what causes this? For me it also gets more horrible when I move or touch down there or after sex. It makes me go crazy cause Even in normal Daily situations I can not forget a second about pssd cause it hurts the whole fucking time

Life is so much worse than what ist used to be before pssd but there are still moments where I can feel a Little Bit of joy.. just live for those moments


I think your described symptoms pretty much overlap with Pudendal Neuralgia. Please take a look on the below link and/or make a search in Google.
https://www.whria.com.au/for-patients/p ... neuralgia/

Although it's weird that ad meds can cause such serious problems.

Re: Trazedy intro - PSSD after Trazodone

Unread postPosted: Sun Mar 31, 2019 4:23 am
by Trazohell
Hello Trazedy,

I have read your story with astonishment and I am very sorry for your ordeal.
But I have hope for you: I suspect more and more that Trazodone triggers something very similar to PSSD, namely CPPS (chronic pelvic pain syndrome). Faith was cured by PT for pelvic floor and also another forum member (I do not write this name 'cause I do not know if he wants it) that took Trazodone too, wrote in hardflaccid forum that he thinks he may never had PSSD but pelvic floor dysfunction.
I myself will soon be back in physiotherapy and will report further successes.
I've also started with supplements that are recommended by hardflaccid people: ginkgo, L-arginine and magnesium.
But I think only a combination of mental stability and pelvic floor healing can get us out of here.

Re: Trazedy intro - PSSD after Trazodone

Unread postPosted: Fri Apr 19, 2019 11:50 am
by Dalmatian
Trazohell and Trazedy can you get in touch with me somehow? I have similar symptoms as you after taking Trazodone for anxiety disorder

Re: Trazedy intro - PSSD after Trazodone

Unread postPosted: Sun May 05, 2019 10:34 am
by Trazedy
@Trazedy: Thanks. I hope you get better too. I'm 100% sure I have PSSD because CPPS doesn't fit my symptoms.

@Dalmatian: Sure! I've sent you a private message.

@ALL: I seem to have a slight improvement in orgasmic response. I will write an update in a week or so.