Page 2 of 2

Re: DGS94 Intro

Unread postPosted: Mon May 27, 2019 5:57 am
by Mesolimbo
DGS94 wrote:Hey @Meso, little update:
The first week on Baclofen seemed to be pretty effective. I felt more loving toward my girlfriend, and felt teary a couple of times from shows/movies/music. I'm back on day 3 of week 2, and the effects seem somewhat diminished, but still present. Also, I had no sexual improvement (but that was expected from others' experiences so far?)

Another thing I just realised I didn't mention in my initial post, while I was on Pristiq, I was taking pretty silly amounts of MDMA and speed fairly frequently (at times every weekend). Would that point your theory on my PSSD type in one direction or another?

First of all, great to hear that you continue to see improvements. Baclofen fixes some PSSD symptoms, it doesn't boost libido much. Since your PSSD is complex, I decided to take it slow, but now you are ready for the next step.

You are experiencing tolerance to Baclofen's effect, which is normal. For tolerance prevention, best option is Memantine, but if you can't get that, you can also try SJW before sleeping.

For libido, you must first restore erectile function, for this I really like L-Arginine (or L-Citrulline) + a PDE5 inhibitor. This can leave permanent effect, and you may only need the PDE5 inhibitor only once per week. I also suggest starting to add chili hot pepper powder to 1 meal of the day.

MDMA causes postsynaptic 5HT1A desensitization, so it augments your type of PSSD pathology, causing more desensitization from the SRI.

Re: DGS94 Intro

Unread postPosted: Mon May 27, 2019 1:37 pm
by DGS94
Hey, thanks for the reply :)

Memantine is a little costly for me since I'd be buying it from one of those dodgy online pharmacies, but I can definitely get my hands on SJW. I've heard there are two types of SJW, do you recommend/prefer one over the other?

I've just ordered some L-Arginine and have PDE-5 inhibitors on hand. What would the dosages look like for those 3?

And finally, in that case I'll avoid MDMA as much as possible.

Thank you again for your help mate!

Re: DGS94 Intro

Unread postPosted: Wed May 29, 2019 2:04 am
by Mesolimbo
DGS94 wrote:Hey, thanks for the reply :)

Memantine is a little costly for me since I'd be buying it from one of those dodgy online pharmacies, but I can definitely get my hands on SJW. I've heard there are two types of SJW, do you recommend/prefer one over the other?

I've just ordered some L-Arginine and have PDE-5 inhibitors on hand. What would the dosages look like for those 3?

And finally, in that case I'll avoid MDMA as much as possible.

Thank you again for your help mate!

Memantine is well-worth the price as it upregulates 5HT1A receptors, D2-family receptors, nAChR7, and GABA-B receptors all in one drug. SJW upregulates only the 5HT1A receptors, so it's less than ideal. It also upregulates 5HT2A receptors, inhibiting dopamine. You can use any SJW supplement, it doesn't matter.

L-Arginine: 1000 mg.
SJW: 300 mg before sleeping.
PDE5 inhibitor: Which one? usually 1 pill is enough, since it comes in standard dose

Re: DGS94 Intro

Unread postPosted: Wed May 29, 2019 2:58 am
by DGS94
I can order some in a couple of weeks, but it'll take about a month to arrive so I guess I'll try out SJW in the meantime.

I've got 100mg Viagra, do you reckon 50mg should be enough? Or should I just got for the 100mg?

Re: DGS94 Intro

Unread postPosted: Wed May 29, 2019 3:07 am
by Mesolimbo
50 mg should be enough. As you build up NO in your body, and take PDE5 inhibitor before sleeping, your endothelial function would improve permanently. Myself, I need less and less of PDE5 inhibitor, I'm currently taking it only once or twice per week and I experience permanent effects.

Re: DGS94 Intro

Unread postPosted: Mon Jun 10, 2019 9:48 pm
by DGS94
Hey, quick update:

I stopped taking Baclofen as I was experiencing insomnia (I never really have sleep issues). I started a new job last week, so I can't go without sleep at the moment!

I've also noticed that I'm really struggling to focus and process information. I used to be great with thinking logically (maths, etc), but I'm finding it really tough atm. Does anyone have any suggestions for something to help with cognitive function?

Re: DGS94 Intro

Unread postPosted: Thu Jul 04, 2019 5:42 am
by Mesolimbo
DGS94 wrote:Hey, quick update:

I stopped taking Baclofen as I was experiencing insomnia (I never really have sleep issues). I started a new job last week, so I can't go without sleep at the moment!

I've also noticed that I'm really struggling to focus and process information. I used to be great with thinking logically (maths, etc), but I'm finding it really tough atm. Does anyone have any suggestions for something to help with cognitive function?

You were getting tolerant to Baclofen either way without something to stop tolerance. For cognitive function, personally I use a very low dose of AChEIs such as Donepezil (1.25 mg) or Rivastigmine (1.5 mg). They help immensely alongside Rasagiline. If I'm having an especially bad brainfog day, I drink diet coke for a boost in aspartame.

Re: DGS94 Intro

Unread postPosted: Thu Jul 04, 2019 5:42 am
by Mesolimbo
DGS94 wrote:Hey, quick update:

I stopped taking Baclofen as I was experiencing insomnia (I never really have sleep issues). I started a new job last week, so I can't go without sleep at the moment!

I've also noticed that I'm really struggling to focus and process information. I used to be great with thinking logically (maths, etc), but I'm finding it really tough atm. Does anyone have any suggestions for something to help with cognitive function?

You were getting tolerant to Baclofen either way without something to stop tolerance. For cognitive function, personally I use a very low dose of AChEIs such as Donepezil (1.25 mg) or Rivastigmine (1.5 mg). They help immensely alongside Rasagiline. If I'm having an especially bad brainfog day, I drink diet coke for a boost in aspartame.