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thoughts on trazdone reboxetine combo?

Unread postPosted: Sat Aug 26, 2017 1:06 pm
by magnilo
Hi all
i have my next appointment with the shrink in about three weeks and i don't want to sit idle in the meantime
i have some leftover pills of reboxetine and trazodone, two treatments i discontinued way too soon, in retrospective.

reboxetine had an extremely weird effect on my awareness, made me feel slow but more peaceful and aware in a weird way. sexually, it had an extreme impact in the sense that it made my penis shrink a lot and it made me feel orgasm before ejaculating, pretty weird but it is something that subsided as i lowered the dose

trazodone on the other hand was very sedating at the beginning, but that subsided after some days of dosing. as i tried to go up to 200mg i felt like a zombie and i most certainly won't go up there anymore. it did have some good properties for erection. one of its rare side effects is priapism.

from a receptors binding profile
trazodone i think it is going in the famous 5ht1a agonism 5ht2a/c antagonism profile. although 5ht2c is very weak at low doses
reboxetine is mainly an extremely clean NE reuptake inhibitor but has some affinity for 5ht2c which could help the trazodone

all in all with my extremely superficial understanding of these dynamics i would say it seems like a fairly good option to try also because of the stimulating properties of the reboxetine that would make the trazodone more suitable for normal day productivity.

does anyone have thoughts on that?

Re: thoughts on trazdone reboxetine combo?

Unread postPosted: Sat Aug 26, 2017 1:48 pm
by Jaxx
If you took them long enough to at least see how they worked for you, i would actually sit idle. Main reason is that if you would get another drug, there is often an 2-week (or so) period between drugs.
Im a bit surprised by the reboxetine experience though. For me NE impact was often high energy and heart rate, definately not calming (was TCA though).

Re: thoughts on trazdone reboxetine combo?

Unread postPosted: Sat Aug 26, 2017 1:57 pm
by magnilo
Someone on Longecity.org asked me if I would descrive it as if "time slowed down" and I do think that it is a pretty good way of putting it! Mind you im a bit on the add in attentive spectrum...

Anyway I did take them but never together! I think they could synergize and complement each other

Re: thoughts on trazdone reboxetine combo?

Unread postPosted: Sun Aug 27, 2017 10:43 am
by magnilo
I've found this interesting study on the combination of trazodone and yohimbine. I guess yohimbine would maybe be another attempt useful to rule out norepinephrine https://www.ncbi.nlm.nih.gov/pubmed/7974947

Re: thoughts on trazdone reboxetine combo?

Unread postPosted: Tue Aug 29, 2017 8:37 am
by magnilo
in the following study they state that yohimbine asserts the inverse action of reboxetine and acts as an antidote of the latter.
does anyone understand why?!
https://www.ncbi.nlm.nih.gov/pubmed/12932821

Re: thoughts on trazdone reboxetine combo?

Unread postPosted: Thu Oct 11, 2018 12:04 pm
by zadig777
magnilo wrote:in the following study they state that yohimbine asserts the inverse action of reboxetine and acts as an antidote of the latter.
does anyone understand why?!
https://www.ncbi.nlm.nih.gov/pubmed/12932821


This effect was reversed following co-infusion of yohimbine, which has been shown to possess both alpha(2)-adrenoceptor antagonist and 5-HT(1A) agonist properties.

yohimbe-alpha(1)-adrenoceptor antagonist and 5-HT(1A) agonist

trazodone--alpha(2)-adrenoceptor antagonist and 5-HT(1A) agonist

reboxetine-effect opposing to trazodone and yohimbe