Sarcosine + NAC. Glutamatergic combination

[jaiho]

This combination has great promise in treating Anhedonia, negative schizo symptoms, and perhaps PSSD.

Its used in this product http://profrontal.com/

With reported, 'Personality Reemergence' that comes after prolonged periods of brain fog & anhedonia.

It can increase libido & sexual function. I'm always trying to find alternatives to using psychiatric drugs. This looks great, as Sarcosine also affects pathways similar to Ketamine, and the new drugs based on Ketamine are glycine co-agonists. Sarcosine is a glycine reuptake inhibitor.

Glutamate might have a large role to play in PSSD & Depression.

[marsupial]

Can you try that Jaiho?? Sounds interesting

[Kinncrimson]

sarcosine doesn't help, tried it for 50 days at 3 grams

[Kinncrimson]

sarcosine doesn't help, tried it for 50 days at 3 grams

[Kinncrimson]

sarcosine doesn't help me, tried it for 50 days at 3 grams.

[jaiho]

From what i read over at longecity, NAC seems to be an important component of the two, and they work together better.

[DoIt]

I will def try this if they ship to my country

[raven100]

Copy and paste, lot of success stories for anhedonia:

Success story 1, from a user on forum.schizophrenia.com called "dmdar": "I take 3000mg of sarcosine paired with 3000mg of NAC (N-Acetyl-Cystine), it's a product called ProFrontal. I have been taking it every day for close to a year and it has nearly miraculously healed me of my negative symptoms with no side effects, I am still seeing improvements on a daily basis.It supposively has the ability to reverse schizophrenia-induced brain damage and I get the sense that it has done that and that some of the improvements are permanent!"

He also said the following things over the course of time: "(Improvements) started almost immediately after I took the first dose."//But he also said: "It takes awhile for it to start working, I have been on it for close to a year and I am still seeing improvements every day."// "I have tried NAC alone and it didn't do much of anything but it seems to have a synergistic effect with sarcosine."//"I experienced the exact same thing, the L-Theanine amplifies the effect of the sarcosine by alot, I take it every day!"//"It's really not either a stimulant or depressant, it works on the negative symptoms of schizophrenia. I can smile and laugh for the first time in years and have started feeling pleasure in day to day activities for the first time in my life. I don't know what to do with myself! If it doesn't work at first keep trying, I've been on it for a good 6 months and I'm still seeing improvements."//"Yes I agree, ProFrontal has helped me alot, it works alot better than just straight sarcosine."//"I take it in pill form, it's a product called Profronal which is NAC (N-Acetyl-Cystine) in combination with Sarcosine. Each pill has 1g of Sarcosine in it so I take 4 pills twice a day, it works great."//"I take 4g split into 2g doses,I started off with 2g but I worked up to 4g and it's working much better now. I've been consistently taking sarcosine for about 6 months now and I'm still seeing some improvement, it works great!"//"I finally decided to try a supplement called ProFrontal (sarcosine and N-Acetyl-Cysteine). I've taken a few doses and it seems to work at least 10 times better than straight sarcosine"

Success Story 2 His anhedonia was caused by accutane, sarcosine+nac helped him! (more so than sarcosine alone) Look for the video called "Anhedonia breakthrough: Sarcosine and N-Acetyl-Cysteine?" By Best Person Ever on youtube. And here's an update from him: "I have been on sarcosine (from Profrontal) for about a month now. Hell, i even dropped the nac. Turns out the magic was contained within the sarcosine all along! So why was my first trial with sarcosine--several months ago--so mediocre? Well, perhaps the sarcosine from Powder City wasn't it all was cracked up to be. Or perhaps the real synergy with sarcosine is with the ALCAR I have been taking, or the Ashwagandha (apparently Ashwagandha might do something similar to nac), or Magnesium, or whatever else. Well, in any case, I regularly feel euphoria now. I wake up feeling like I am on Adderall some days. Brain is really coming online. Verbal fluency is improved, minus anxiety-inducing situations. But that was something I always had. Point is, I feel driven af. Life actually feels good. It's incredible. Please, try sarcosine. With or without NAC. NAC can probably help many, probably helped me too. It just acted on IBS too much. But personally, it appears the real synergy is coming from something other than NAC, contrary to what I previously thought." (we suspect the NAC might have helped to kick off the sarcosine response at the beginning)

Success Story 3: "It is hard to believe even for myself, but after about 3 weeks, I found my residual anhedonia and dissociation lifted." "Another thing is sarcosine is apparently hard to get, so people buy from smartpowders or powdercity. I tried that at first, and they did little to nothing for me. So I went to a compounding pharmacy and ordered a bag of sarcosine through them. Turns out supplement companies sell crap - who'd have guessed? The pharmacy sarcosine worked like a charm." "Sarcosine adds further antidepressant effect to the tranylcypromine (parnate) that I'm taking, and I feel it makes me more engaged with reality, a bit more motivated." (so only sarcosine was enough for him in his case, but maybe he could benefit even more by adding NAC) https://www.reddit.com/r/depressionregi ... osine_and/

Success Story 4: I took 1 gram of each (sarcosine and nac) for two weeks. I now take 2 g of NAC + Sarcosine per the instructions on the Profrontal bottle. It's as effective as anything I've tried. The effect is natural, not an 'artificial' mood boost you get with stimulants or marijuana for example. It's not a complete overhaul or miracle cure; it's more like a gradual, subtle return of affective experience. I basically felt like I was doomed prior to starting this regimen. I'm also a skeptic when it comes to 'natural' cures or functional medicine; I've tried many nutraceuticals (methylfolate, probiotics, fish oil, zinc, adaptogens) to no avail. Sarcosine has substantial pharmacological activity and hits my brain in exactly the right places.

Update: almost 4 weeks in, still having success with profrontal I would say right now i'm like half-anhedonic, I went from 80% anhedonia, to now feeling like I'm at 40-50%. I actually don't know if it's any different than how I was before my main depression onset a few years ago. I think I've always had some degree of anhedonia, come to think of it. That said, partial anhedonia's waaaaaay better than severe anhedonia. Both my anticipatory and consummatory anhedonia have improved.

I think it's a combo of stress/drug-induced changes (prozac+zyprexa) that I took for a while when I was younger/and natural progression of mental disorder that led me to develop anhedonia anhedonia about 4 years ago

Tip from him: the effects usually kick in down the road, not instantly. you might notice a change like I did the first time you take it but that isn't reflective of the actual effects

By Tim in the Facebook group for anhedonia: https://www.facebook.com/groups/anhedon ... ?ref=br_rs

Success Story 5: "2 weeks of Sarcosine + NAC now: -Sex drive is noticeably higher -Music is slightly more "immersive" -Sense of touch is slightly improved That last one's tricky, but things feel a little more vivid. At my worst, I could lay my head on a pillow and feel nothing, but now it's comfortable and pleasant. However, that was all within the first week. I've noticed no further developments past day 5 or 6, really."

(He's taking the sarcosine+nac supplement called Profrontal.) He also said: (and you were anhedonic before) "Yes, extremely. I still am, but slightly better than before. And apparently this supplement takes 4-6 weeks to really kick in, so I'm quite optimistic. Hopefully in a week or two, I can report back even better changes, but that's all for now." (I'll update the post when he updates his results).

My dose is 2 pills of 500mg of Sarc and 2 pills of 500mg of NAC, per dose

2 doses a day. Total of 2g of each/day

So 8 capsules per day

It's from fieryterminator in the discord group (a group for anhedonia sufferers):https://discordapp.com/invite/3Tn9R6A

Success Story 6: I started off with two capsules of each a day and then increased two two twice a day. It was only after the increase in dosage that I felt reborn. Though I have never been diagnosed as schizophrenic, I was diagnosed as having a psychotic episode last year brought on my drug abuse. The delusions I had luckily subsided after I quit abusing drugs but I still felt depressed and displayed the negative symptoms of schizophrenia. After only a few weeks on Profrontal I have started regularly laughing again (something I didn't do in a long time) and I was able to go out and face life's challenges. by Frederick http://profrontal.com/testimonials/

Success Story 7: "I've been taking sarcosine for the last couple weeks and I can already tell there are differences. Granted, I also tried a ketamine infusion Monday before last, so I'm sure that helped too. But even from just the first week I could tell something was different although I couldn't tell what at the time." (It's from AlTheKiller2113 in the discord group (a group for anhedonia sufferers):https://discordapp.com/invite/3Tn9R6A)

Success Story 8: Sarcosine update (day 15 domething) Since day 12, I noticed that my mood seems to have been improving reaaally good .. like caffeine high positiveness . Also music sounds fuckin nice .. and i have more empathy for my gf and found her more and more sweeter .. and generaly more posiive on sarcosine+NAC, I take profrontal ...I take 1g of each x 2times a day (threekings from the discord group)

[Juvo]

Thanks Raven. Definitely putting on my short list of things to try.

[raven100]

My medical knowledge consists of entirely what I read on wikipedia articles, but apparently this is the intermediate in the metabolism of choline to glycine? We've seen people on the forum get serious benefits from taking Choline too right?