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Re: L-Cysteine and L-Histidine

Unread postPosted: Thu Feb 01, 2018 3:18 pm
by Jaxx
zinc finger thread, but yes it is messy. Maybe start at Tubzy's signature

Re: L-Cysteine and L-Histidine

Unread postPosted: Wed Feb 07, 2018 12:36 pm
by Jaxx
Anyone still running the full protocol? Good news that Amazon cannot geoblock anymore in Europe in the near future, it's a pain to find and ship all the stuff!

Re: L-Cysteine and L-Histidine

Unread postPosted: Thu Feb 08, 2018 1:09 am
by silverstar
I've been trying this for about a week and noticed a slight chance in numbness. Have sightly more feeling.
Nothing to write home about yet though.

Re: L-Cysteine and L-Histidine

Unread postPosted: Thu Feb 08, 2018 1:59 pm
by Jaxx
silverstar wrote:I've been trying this for about a week and noticed a slight chance in numbness. Have sightly more feeling.
Nothing to write home about yet though.

What are you taking exactly?

Re: L-Cysteine and L-Histidine

Unread postPosted: Thu Feb 08, 2018 8:47 pm
by JayR
silverstar wrote:I've been trying this for about a week and noticed a slight chance in numbness. Have sightly more feeling.
Nothing to write home about yet though.

Great to hear!

Re: L-Cysteine and L-Histidine

Unread postPosted: Thu Feb 08, 2018 9:25 pm
by silverstar
I'm taking L-Cysteine and L-Histidine, I might up my dosage soon. Just been taking one pill of each from Now foods for the l-cysteine and one pill of the l-hisadine I'll find out the brand and dosage and edit this

NOW L-Cysteine 500 mg,100 Tablets
Swanson Ajipure L-Histidine, Pharmaceutical Grade 500 mg 60 Veg Caps

Re: L-Cysteine and L-Histidine

Unread postPosted: Fri Feb 09, 2018 2:39 pm
by Jaxx
silverstar wrote:I'm taking L-Cysteine and L-Histidine, I might up my dosage soon. Just been taking one pill of each from Now foods for the l-cysteine and one pill of the l-hisadine I'll find out the brand and dosage and edit this

NOW L-Cysteine 500 mg,100 Tablets
Swanson Ajipure L-Histidine, Pharmaceutical Grade 500 mg 60 Veg Caps

The protocol they originally talk about has more though. If this works for you great, if not, you might want to consider the full version.

Re: L-Cysteine and L-Histidine

Unread postPosted: Thu Feb 15, 2018 5:05 pm
by expendable
6 or so days now on cysteine HCL and histidine HCL, added magnesium, manganese, potassium, silicon, arganine, lysine, brewer's yeast, recently added copper and zinc.

There are definite improvements. I'm starting to believe this craziness. It's too early to tell for now but I'm going to see what happens the next few days.

Re: L-Cysteine and L-Histidine

Unread postPosted: Fri Mar 16, 2018 3:03 am
by Coraggio
Guys I' ve found some science behind this.

Given that PSSD can be easely told as an Autistic like behaviour caused by SSRI exposure (Citalopram exposure in early rat life causes autism).
Austism, indeed, displays an increase in endogenous opiods and it seems that can blunt opiod receptors. We have an opiod imbalance too and this is very probable given our anhedonia and the similarities with autsim.

So, this study demonstrates that an opiod imbalance can trigger abnormalities in brain uptake cysteine:
https://www.sciencedirect.com/science/article/pii/S0955286314001144

"Food-derived opioid peptides inhibit cysteine uptake with redox and epigenetic consequences☆

Abstract
Dietary interventions like gluten-free and casein-free diets have been reported to improve intestinal, autoimmune and neurological symptoms in patients with a variety of conditions; however, the underlying mechanism of benefit for such diets remains unclear. Epigenetic programming, including CpG methylation and histone modifications, occurring during early postnatal development can influence the risk of disease in later life, and such programming may be modulated by nutritional factors such as milk and wheat, especially during the transition from a solely milk-based diet to one that includes other forms of nutrition. The hydrolytic digestion of casein (a major milk protein) and gliadin (a wheat-derived protein) releases peptides with opioid activity, and in the present study, we demonstrate that these food-derived proline-rich opioid peptides modulate cysteine uptake in cultured human neuronal and gastrointestinal (GI) epithelial cells via activation of opioid receptors. Decreases in cysteine uptake were associated with changes in the intracellular antioxidant glutathione and the methyl donor S-adenosylmethionine. Bovine and human casein-derived opioid peptides increased genome-wide DNA methylation in the transcription start site region with a potency order similar to their inhibition of cysteine uptake. Altered expression of genes involved in redox and methylation homeostasis was also observed. These results illustrate the potential of milk- and wheat-derived peptides to exert antioxidant and epigenetic changes that may be particularly important during the postnatal transition from placental to GI nutrition. Differences between peptides derived from human and bovine milk may contribute to developmental differences between breastfed and formula-fed infants. Restricted antioxidant capacity, caused by wheat- and milk-derived opioid peptides, may predispose susceptible individuals to inflammation and systemic oxidation, partly explaining the benefits of gluten-free or casein-free diets."

In particular this study explain why many austistic's mothers report improvements giving a gluten casein free diet to their children. So, here we are: if L-cysteine deserves his properties to PSSD and PFS patients, this is the final proof that we have an opiod imbalance for sure.

What we should do in my opinion: a gluten-free casein free is highly recommended. (I suggest also a a high fiber, high micronutrient diet in order to increse your butyrate production in your colon throught fiber microbiota fermentation. Butyrate has many metabolic, neurological and endocrinology benefits like increasing the sexual steroid receptors affinity and repair the Blood Brain Barrier).

Maybe a L-cysteine supplementation can do his work, but pay attention to do not more damage!

Important notes: 1) we normally eat wheat with higher gluten content than our grandpas ate, because science has selected more resistant wheat to grow that display more gluten.
2)Other good habits are eating maximum 3 times/day. Eating more frequintly is associated with a brain SERT decrease.
3) Gluten withdrawal is reported as dizziness, brain fog and others symptoms. I' ve found that usually it takes some weeks to go away. I think it could be a good idea decreasing it slowly.

Re: L-Cysteine and L-Histidine

Unread postPosted: Fri Mar 16, 2018 2:26 pm
by Halan
What about NAC?
I tried it, but with no effects
it's N-acetyl-cysteine

I'm allergic to casein and gluten, but this got very bad after pssd
Idk if it's coincidence or related