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Unread postPosted: Sun Jun 10, 2018 8:16 am
by iii1i1i1
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Re: Pramipexole (Success)

Unread postPosted: Mon Jun 11, 2018 4:07 am
by nasibi
I have started the Pramipexole trial. I will be doing 0.35/day for a week, then go with 0.7/day for the rest of 2-3 weeks.

Re: Pramipexole (Success)

Unread postPosted: Mon Jun 11, 2018 7:39 am
by Steven
Do you take Pramiprexol Retard Tablets which releases the active ingredients during the day?

Re: Pramipexole (Success)

Unread postPosted: Mon Jun 11, 2018 12:51 pm
by Jaxx
nasibi wrote:I have started the Pramipexole trial. I will be doing 0.35/day for a week, then go with 0.7/day for the rest of 2-3 weeks.


Awesome, really curious to hear how it will work out for you. Please update us when you can :)

Re: Pramipexole (Success)

Unread postPosted: Mon Jun 11, 2018 2:09 pm
by nasibi
Jaxx wrote:
nasibi wrote:I have started the Pramipexole trial. I will be doing 0.35/day for a week, then go with 0.7/day for the rest of 2-3 weeks.


Awesome, really curious to hear how it will work out for you. Please update us when you can :)


I will keep you guys updated.

Re: Pramipexole (Success)

Unread postPosted: Tue Jun 12, 2018 5:21 am
by nasibi
Steven wrote:Do you take Pramiprexol Retard Tablets which releases the active ingredients during the day?


No. Just the regular Mirapex brand.

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Unread postPosted: Tue Jun 12, 2018 8:08 pm
by iii1i1i1
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Re: Pramipexole (Success)

Unread postPosted: Wed Jun 13, 2018 1:11 pm
by magnilo
iii1i1i1 wrote:https://www.ncbi.nlm.nih.gov/pubmed/18688211/:
"Pramipexole (PPX) is a D(2)/D(3) receptor agonist that has been shown to be effective in the treatment of depression. Serotonin (5-HT), norepinephrine (NE) and dopamine (DA) systems are known to be involved in the pathophysiology and treatment of depression. Due to reciprocal interactions between these neuronal systems, drugs selectively targeting one system-specific receptor can indirectly modify the firing activity of neurons that contribute to firing patterns in systems that operate via different neurotransmitters. It was thus hypothesized that PPX would alter the firing rate of DA, NE and 5-HT neurons. To test this hypothesis, electrophysiological experiments were carried out in anesthetized rats. Subcutaneously implanted osmotic minipumps delivered PPX at a dose of 1 mg/kg per day for 2 or 14 days. After a 2-day treatment with PPX the spontaneous neuronal firing of DA neurons was decreased by 40%, NE neuronal firing by 33% and the firing rate of 5-HT neurons remained unaltered. After 14 days of PPX treatment, the firing rate of DA had recovered as well as that of NE, whereas the firing rate of 5-HT neurons was increased by 38%. It was also observed that sustained PPX administration produced desensitization of D(2)/D(3) and 5-HT(1A) cell body autoreceptors, as well as a decrease in sensitivity of alpha(2)-adrenergic cell body autoreceptors. These adaptive changes are implicated in long-term firing rate adaptations of DA, NE and 5-HT neurons after prolonged PPX administration. In conclusion, the therapeutic action of PPX in depression might be attributed to increased DA and 5-HT neurotransmission."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101890/#b3-ndt-7-297:
"Biochemical and electrophysiological aspects of dopaminergic autoreceptor desensitization have also been described previously. It was observed that sustained pramipexole administration produced desensitization of D2/D3 and 5-HT1A cell body autoreceptors, as well as a decrease in sensitivity of α2-adrenergic cell body autoreceptors."


im not really sure i understand... i guess its bad?

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Unread postPosted: Thu Jun 14, 2018 2:45 pm
by iii1i1i1
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Re: Pramipexole (Success)

Unread postPosted: Thu Jun 14, 2018 6:01 pm
by Steven
Yesterday evening on 0.70 mg gone and Zack I was cool again and had 2 erections at night but I am now 17 days on pramipexole and think slowly to go down I hope the head remains so clear