PSSD Collaborative Research

Gonzo on Thu Nov 06, 2014 5:17 pm

When I try to have sex, I always take either Viagra, Cialis or Levtra. They doesn't work anyway, but it improves the chances of having a better erection. But by no means I can get an erection without manual stimulation and I never can keep it.

I began to suffer Stuffy nose. It's a nasty side effect from this drugs. I read that it is caused by an histamine reaction. So the other day, I took 20mg of levitra together with Loratadine to counteract the stuffy nose. And about 40 minutes later, I started to have a hard rock erection, just with my libido and nothing else, no other stimulation. I almost couldn't stop the erection during 4 hours! rock hard at some moments, and not that hard at other moments. But I could stopped if I wanted, so it wasn't priapism. I got scared a few times so I tried to move around a little bit and distract my mind to stop the erection. But it took me some effort.... This is so weird. This is the first time since PSSD that I have to fight to stop an erection!. (Aside from my priapism induced by Trimix)

Before posting this, I tried this mix a second time. It worked again.

I made a google research about loratadine, and some claim that it works for SSRI inuced sexual dysfunction. I have no idea how loratadine works. It has no side effects at all.

I have taken this 2 drugs before many times, but not together, and without effect in the erection.

Levitra alone doesn't work for the erection! I've tried it thousand of times without succes. Loratadine does something! It can't be coincidence. Although No effect over the anesthesia and orgasm.

Today I start Mianserin.


Ghost on Thu Nov 06, 2014 9:39 pm

That's very exciting Gonzo!

It's properties as an anti-histamine must've done the trick!

I'm guessing that the Loratadine doesn't give you this side effect on it's own?

That's unfortunate that it doesn't have relieve your other symptoms as well...

Excited to hear how Mianserin works for you! The other man from Italy should be nearly off of it by now, wondering how he is doing...




Post Gonzo on Thu Nov 06, 2014 11:32 pm

It is the combination of both, that for some reason allows me to have an erection. Levitra alone doesn't work for me, and loratadine alone, for sure doesn't give me erections.

Yes, I'll let you know how is everything going with Mianserin.


Post Covered_in_bees on Fri Nov 07, 2014 7:42 am

Well, I'm going to be making a little trip to the pharmacy for some Claritin. I'll give it a shot with Levitra. Thanks! Laughing



Post Gonzo on Fri Nov 07, 2014 1:01 pm

Good. Try to take them with empty stomach.

I took the mianserin and had the best night of my life. Slept like a babe. The pill knocks the hell out of me in 50 minutes and gave me a nice sleep, which I needed. I've just woke up and feels great. But, it may be affecting my skin. So if that happens, I'm done for now...



Post tempus on Fri Nov 07, 2014 2:10 pm

i think it's similar to cyproheptadine

stuffy nose is due to vasodilator effect of pde5 inhibitors drugs, not histamine. am i wrong?



Post Ghost on Fri Nov 07, 2014 2:15 pm

Gonzo wrote:Good. Try to take them with empty stomach.

I took the mianserin and had the best night of my life. Slept like a babe. The pill knocks the hell out of me in 50 minutes and gave me a nice sleep, which I needed. I've just woke up and feels great. But, it may be affecting my skin. So if that happens, I'm done for now...

Too bad about it possibly affecting your skin. Has it done so already? If it's helping you sleep, I may suggest trying to put the skin issues aside unless they are truly unbearable. Getting a good night's sleep will a) Decrease stress b) Increase your bodies ability to heal c) Make you feel better, and finally (Maybe most importantly) enough sleep can help alter gene expression...That may be a key part in recovering from PSSD...I feel that a lot of people with PSSD don't sleep enough each night. Not saying that's the cause/ your case...but it may make it persist longer/ be more severe. Also Mianserin could help with PSSD as well.

http://www.ncbi.nlm.nih.gov/pubmed/11682270
"it is already apparent that the transition from sleep to waking can affect basic cellular functions such as RNA and protein synthesis, neural plasticity, neurotransmission, and metabolism."

"ust one week of mild sleep deprivation affects the function of 711 different genes. This according to researchers at the University of Surrey in the U.K., including chronobiologist Simon Archer. His team took blood samples from volunteers over the course of a week. One group slept eight hours a night; the other, six."
http://sciencenetlinks.com/science-news ... xpression/

" British researchers have showed that over time, insufficient sleep directly alters gene expression responsible for processes like immune responses, stress, and metabolism, which have a wide range of negative downstream effects."
http://www.medicaldaily.com/one-week-sl ... isk-244519


One last thing...Does it also increase the quality of your sleep? I sleep as much as before Lexapro...but I wake up feeling like a zombie...not refreshed like I used to.




Post Ghost on Fri Nov 07, 2014 2:20 pm

tempus wrote:i think it's similar to cyproheptadine

stuffy nose is due to vasodilator effect of pde5 inhibitors drugs, not histamine. am i wrong?


I should know better than to quote Wikipedia...but the Cyproheptadine Wiki page had this to say...

"Can relieve SSRI-induced sexual dysfunction"

And then...

http://www.medscape.com/viewarticle/430614_5
"12 of 25 patients described improvement in sexual function when treated with cyproheptadine (mean dose, 8.6mg).[13] Anorgasmia is the sexual side effect most often reported to be alleviated by cyproheptadine. Cyproheptadine is effective when taken either on an as-needed basis (typically, 1 to 2 hours before intercourse) or on a regular basis."

I don't know if this is well known PSSD knowledge or not...I haven't been at this long enough. Hope it helps tho!


Post Gonzo on Sat Nov 08, 2014 1:16 am

Now, 24 hours later, same story, my face is swollen with red patches. So no more mianserin for now.

I tried again the levitra / loratadine mix, and it didn't worked . But anyway, this is not uncommon with PSSD medications. If it doesn't work again, I can't explain the succes of the 2 previous days. I can't win Crying or Very sad


Post Ghost on Sat Nov 08, 2014 1:44 am

Gonzo wrote:Now, 24 hours later, same story, my face is swollen with red patches. So no more mianserin for now.

I tried again the levitra / loratadine mix, and it didn't worked . But anyway, this is not uncommon with PSSD medications. If it doesn't work again, I can't explain the succes of the 2 previous days. I can't win Crying or Very sad

Another thing to think about Gonzo is that Mianserin has a very high half life. Like 21-61 hours. Because of this you could probably take a smaller dose every other/ every third night and that may reduce negative side effects while allowing any positive PSSD affects to occur. Also would insure more good nights of sleep. However, I Don't blame you if you don't take it again. That sucks about the red patches. Take care!



Post Covered_in_bees on Sat Nov 08, 2014 4:34 pm

Gonzo,
First: thanks for the tip. I tried it today. After 30-40 mins, the erection was by far the hardest I've had since the onset of pssd. It was pretty awesome.

I also developed the erection without any manual stimulation. BUT, you mention that it happened to you from your 'libido'. To me, it felt much like an erection from a PDE-5 inhibitor, that is, "just there". I didn't seem to be a result of being turned on at all.

Somehow, I feel like the same thing will happen to me. It may work once or twice more, but most things seem to fail after that.

That said, I found it easier to get "into things" (no pun intended

I will post if I have continued success with this.

Thank you! A helpful find.


Post Gonzo on Sat Nov 08, 2014 5:06 pm

That's cool!

I think you are right and I'm confusing the things! I mean, it is the erection that activates my libido. I didn't got the erection from my libido. It's exactly how you describe it. To me it's also like an automatic erection. It was pretty much the same feeling than when injecting trimix to the penis to get an erection. Maybe I failed the third time because I was not 100% with empty stomach, because when I got the erection the first time, I imnediately though, the only 2 things that I did was taking Loratadine and number 2, I Haven't eaten a lot of hours.. I will also keep trying it. For me, it was actually the best erection that I've had in 10 years (Since PSSD), aside from the priapism that I had.


Post tempus on Sun Nov 09, 2014 10:22 am

Covered_in_bees wrote:Gonzo,
First: thanks for the tip. I tried it today. After 30-40 mins, the erection was by far the hardest I've had since the onset of pssd. It was pretty awesome.

I also developed the erection without any manual stimulation. BUT, you mention that it happened to you from your 'libido'. To me, it felt much like an erection from a PDE-5 inhibitor, that is, "just there". I didn't seem to be a result of being turned on at all.

Somehow, I feel like the same thing will happen to me. It may work once or twice more, but most things seem to fail after that.

That said, I found it easier to get "into things" (no pun intended

I will post if I have continued success with this.

Thank you! A helpful find.

have you tried only loratedine? what dosage?


Post Covered_in_bees on Tue Nov 11, 2014 8:47 pm

I took 10 mg of Levitra and 10 mg of Loratadine.




Post Gonzo on Thu Nov 13, 2014 11:03 am

I tried cyproheptaine + levitra. Same result. I was able to keep an erection. It helps with the anesthesia and a little bit with the orgasm.

PAGE 2:

post Covered_in_bees on Thu Nov 13, 2014 3:50 pm

Gonzo wrote:I tried cyproheptaine + levitra. Same result. I was able to keep an erection. It helps with the anesthesia and a little bit with the orgasm.

So, does this mean its better than using loratadine? Loratadine had no effect on anesthesia or quality of orgasm.


Post Gonzo on Thu Nov 13, 2014 7:15 pm

So, does this mean its better than using loratadine? Loratadine had no effect on anesthesia or quality of orgasm.

mmm I don't know. For me, the first thing is to recover the erection. Cyproheptadine has a sedative effect and loratadine doesn't have any side effect at all. So I was kinda high, but at least with an erection. But I have a feeling that both drugs will stop working after a couple of times. I will keep experimenting. I think that Loratadine also works by blocking serotonin.



Post MarioAnttonen on Fri Nov 14, 2014 2:05 am

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):754-6.

An open-label series using loratadine for the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors.
Aukst-Margetić B1, Margetić B.
Author information
Abstract
OBJECTIVE:

To assess the impact of loratadine as an add-on treatment of erectile dysfunctions associated with selective serotonin reuptake inhibitors (SSRIs).
METHODS:

Nine patients diagnosed as major depressive disorder (MDD), with erectile dysfunction associated with the administration of SSRIs, completed a 2-week trial of loratadine in the dose of 10 mg/day. The International Index of Erectile Function Five (IIEF-5) was used as an assessment measure for diagnosing the presence and severity of erectile dysfunction. The 17-item Hamilton Rating Scale for Depression (HAM-D) was administered for screening the potential impact of depressive symptoms.
RESULTS:

Baseline mean S.D.+/-IIEF-5 scores were 10.33+/-4.55 (range 5-20) and week 2 mean+/-S.D. IIEF-5 was 14.44+/-3.84 (range 10-22). Subjects had statistically significant improvement in their erectile functions on the IIEF-5 (t = -8.485; df = 8; p = 0.000) and 55% reported subjective improvement of the erectile function. No significant changes on HAM-D 17 scores were registered. Baseline mean S.D. scores were 13.66+/-2.29 (range 10-17) and week 2 mean S.D. was 13.11+/-1.96 (range 10-16) (t = 1.47; df = 8; p = 0.179).
CONCLUSION:

Our findings suggest the possible role of loratadine in the treatment of SSRI-associated sexual dysfunction. They are promising, but preliminary. Thus they should be replicated in a longer large-scale, double-blind, placebo-controlled trial.

PMID:
15913872
[PubMed - indexed for MEDLINE]


Post pssd'd on Sun Nov 16, 2014 6:29 pm

Strange find!

There are actually quite a few reports online from non ssri affected men stating that loratadine can cause erectile dysfunction. I wonder why it is that it can help us but have the opposite effect in the more general population?



Post sexdrive on Sun Nov 16, 2014 7:07 pm

http://www.dr-bob.org/babble/20030525/msgs/229290.html

Fluoxetine-Induced Sexual Dysfunction Reversed by Loratadine

Sir: Sexual dysfunction as a side effect of antidepressant treatment occurs at a rate of roughly 50% of treated patients.1 Fluoxetine is no exception. Attempts at reversing sexual side effects in selective serotonin reuptake inhibitors (SSRIs) have included dosage reduction, change to a different SSRI or non-SSRI, and adding bupropion, Ginkgo biloba, cyproheptadine, yohimbine, trazodone, and sildenafil, all with varying degrees of success.2 In this study, loratadine, a long-acting tricyclic antihistamine with selective peripheral histamine H1 receptor antagonistic activity, appeared to be very helpful in reversing fluoxetine-induced sexual dysfunction.

About 12 months ago, one of my male clients with major depression who previously had experienced sexual dysfunction with fluoxetine, 5 mg/day, restarted taking fluoxetine, 5 mg/day, while also taking loratadine, 2.5 mg/day, for allergic rhinitis. The patient was taking these low doses because of being a slow metabolizer of medication in general. Whereas before with fluoxetine he had reported dulling of penile sensation and delayed erection and ejaculation, in the presence of loratadine none of these side effects were present and he reported normal sexual function, which continued at last report.

Due to this initial success with loratadine, over the next 9 months I prescribed, with informed consent, loratadine for fluoxetine-induced sexual dysfunction in 9 additional patients (5 men and 4 women) with a diagnosis of major depression. No sexual dysfunction assessment scales were employed, just the verbal report of each patient within the confines of a typical 15-minute medication review. Before-and-after reports were noted concerning level of sexual interest, delay or absence of erection, and delay or absence of orgasm. Two male patients reported delayed or absent erection and orgasm; 1 male patient reported impotence, anorgasmia, and no sexual interest; 2 male patients had anorgasmia and low sexual interest; 3 female patients reported anorgasmia and no sexual interest; and 1 female patient experienced anorgasmia only. No change in general or psychiatric medications was made. Dosage of loratadine ranged from 2.5 to 15 mg, depending on side effects and efficacy. Most patients were started on 10 mg/day. Seven of 9 patients had complete reversal of sexual dysfunction within 2 days, and the other 2 experienced significant improvement of sexual side effects. One male patient, who had partial impotence and low libido, had function restored to a prefluoxetine state by taking loratadine, 10 mg, 1 day before planned sexual activity. Side effects of loratadine ranged from none to mild-to-moderate dry mouth and sedation, which responded to bedtime dosing or reduction in dose. No change was seen on effectiveness of fluoxetine for depression, although the patients were happy to have their sexual function restored.

Furthermore, a female patient taking nefazadone and sertraline responded nicely to the addition of loratadine for low sexual interest and anorgasmia. I also prescribed loratadine for low sexual interest and anorgasmia to a female patient taking paroxetine and a male patient experiencing impotence who was being treated with citalopram, but neither had a positive response. I have no explanation for this lack of efficacy.

It appears from this small open study that loratadine is a promising agent for reversing fluoxetine-induced sexual dysfunction. These results are subject to the limitations of a retrospective report and the possibility of a placebo-like effect. A larger double-blind controlled study could confirm a generalization of these findings. If confirmed, these findings could prompt an investigation into the mechanism of action of loratadine in reversing sexual dysfunction in patients treated with fluoxetine and possibly lead to development of antidepressants without this side effect. Whether loratadine could be useful for sexual dysfunction induced by other SSRIs awaits further study.


Dr. Brubaker reports no financial affiliation or other relationship relevant to the subject matter of this letter.

References

1. Labbate LA, Lare SB. Sexual dysfunction in male psychiatric outpatients. Psychother Psychosom 2001;70:221-225

2. Woodrum ST, Brown CS. Management of SSRI-induced sexual dysfunction. Ann Pharmacother 1998;32:1209-1215


Russel V. Brubaker, M.D.
Michigan State University
Alto, Michigan

and here some guessing copied from an other forum:"

4. The discussion on mechanism of action is limited to the following paragraph, and this seems to only explain how loratadine might improve erectile function, not other forms of sexual dysfunction. I bolded the significant part, as the following sentence is foolish. (Cyproheptadine works by 5-HT2A antagonism, and likely has little to do with H1.)

The improvement mechanism is unknown so far. The role and function of histamine in the corpus cavernosum physiology are poorly understood. The principal histamine receptor subtype that mediates smooth muscle cell contraction in the corpus cavernosum is H1. The histamine H1 receptor antagonism increases nonadrenergic–noncholinergic neurally mediated corpus cavernosum relaxation and possesses potential as a pharmacotherapeutic agent for the treatment of erectile dysfunction (Kim et al., 1995). Cyproheptadine, H1 first-generation antagonist, and epinastine, second-generation H1 antagonist, have been already proposed as potential therapeutics in the SSRI-caused sexual side effects (Rotschild, 2000; Yamanaka et al., 1999).


5. Though I do not know his motivation, Mariano has experimented with using loratadine to combat sexual side effects with modest success. His theory is that loratadine reduces renin release from the kidney (this part, IIRC, is backed up by evidence) and the reduction in renin improves blood vessel dilation. But I'm not sure about the latter point, particularly as it applies to the corpus cavernosum.

http://www.mindandmuscle.net/forum/show ... post617978



Post Ghost on Sat Nov 22, 2014 9:46 am

MarioAnttonen wrote:Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):754-6.

An open-label series using loratadine for the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors.
Aukst-Margetić B1, Margetić B.
Author information
Abstract
OBJECTIVE:

To assess the impact of loratadine as an add-on treatment of erectile dysfunctions associated with selective serotonin reuptake inhibitors (SSRIs).
METHODS:

Nine patients diagnosed as major depressive disorder (MDD), with erectile dysfunction associated with the administration of SSRIs, completed a 2-week trial of loratadine in the dose of 10 mg/day. The International Index of Erectile Function Five (IIEF-5) was used as an assessment measure for diagnosing the presence and severity of erectile dysfunction. The 17-item Hamilton Rating Scale for Depression (HAM-D) was administered for screening the potential impact of depressive symptoms.
RESULTS:

Baseline mean S.D.+/-IIEF-5 scores were 10.33+/-4.55 (range 5-20) and week 2 mean+/-S.D. IIEF-5 was 14.44+/-3.84 (range 10-22). Subjects had statistically significant improvement in their erectile functions on the IIEF-5 (t = -8.485; df = 8; p = 0.000) and 55% reported subjective improvement of the erectile function. No significant changes on HAM-D 17 scores were registered. Baseline mean S.D. scores were 13.66+/-2.29 (range 10-17) and week 2 mean S.D. was 13.11+/-1.96 (range 10-16) (t = 1.47; df = 8; p = 0.179).
CONCLUSION:

Our findings suggest the possible role of loratadine in the treatment of SSRI-associated sexual dysfunction. They are promising, but preliminary. Thus they should be replicated in a longer large-scale, double-blind, placebo-controlled trial.

PMID:
15913872
[PubMed - indexed for MEDLINE]

Last night I tried 7.5 mg Loratadine just for the hell of it. Thought that it couldn't hurt, and if anything may help me sleep better...Oddly enough...I slept worse...I woke up in the middle of the night, and didn't sleep in as long this morning. I found this very odd, because one of the side effects is drowsiness. As noted about, Loratadine is a H1 antagonist...but I thought something that area said before could possibly relate...he'd know best on this... "IF YOU ARE PRONE TO INSOMNIA (Which I kinda am occasionally)...DO NOT OR TREAD CAREFULLY TAKING HISTAMINE H3 BLOCKERS"...Is it possibly that a H1 blocker caused me some trouble sleeping? I think that I will try another 7.5mg this morning, and no longer take it at night. Also, the shit expired in 2012, so I'm gonna head to the store and buy me some new Claritin. Also interesting is that on the wikipedia page (sorry for sourcing wikipedia again) it had this to say... "In structure, it is closely related to tricyclic antidepressants"... I found that somewhat interesting...I plan on trying this for the next couple of days just to see what happens. Can't go too wrong in my opinion. I'd rather take my chances going "Claritin clear" than with another drug to try and treat this. I'll keep you posted.

edit: I used to have very hot/ sweaty feet. It was really annoying because I had to change socks a lot. After lexapro, my feet are never as sweaty or hot...which has been nice really. This morning they are sweaty and hot again. Coincidence? only time will tell. I'd trade that for my sex life back anyday. Very Happy


Post Gonzo on Sat Nov 22, 2014 10:41 am

Last night I tried 7.5 mg Loratadine just for the hell of it. Thought that it couldn't hurt, and if anything may help me sleep better...Oddly enough...I slept worse...I woke up in the middle of the night, and didn't sleep in as long this morning. I found this very odd, because one of the side effects is drowsiness. As noted about, Loratadine is a H1 antagonist...but I thought something that area said before could possibly relate...he'd know best on this... "IF YOU ARE PRONE TO INSOMNIA (Which I kinda am occasionally)...DO NOT OR TREAD CAREFULLY TAKING HISTAMINE H3 BLOCKERS"...Is it possibly that a H1 blocker caused me some trouble sleeping? I think that I will try another 7.5mg this morning, and no longer take it at night. Also, the shit expired in 2012, so I'm gonna head to the store and buy me some new Claritin. Also interesting is that on the wikipedia page (sorry for sourcing wikipedia again) it had this to say... "In structure, it is closely related to tricyclic antidepressants"... I found that somewhat interesting...I plan on trying this for the next couple of days just to see what happens. Can't go too wrong in my opinion. I'd rather take my chances going "Claritin clear" than with another drug to try and treat this. I'll keep you posted.

edit: I used to have very hot/ sweaty feet. It was really annoying because I had to change socks a lot. After lexapro, my feet are never as sweaty or hot...which has been nice really. This morning they are sweaty and hot again. Coincidence? only time will tell. I'd trade that for my sex life back anyday. Very Happy

If the Loratadine expired in 2012, I think that it didn't make almost any effect at all, or a considerably reduced effect. I don't think that the insomnia was caused by loratadine. At least for me is the only drug that doesn't have any side effect.

Also,, if I take loratadine alone, it doesn't do anything and the same with levitra (or vagra or cialis). But if I take both together = Automatic erection. It's amazing. But I recomend you trying it for sex, because if you use it 2-3 days in a row, I think that it's not going to work. Or maybe it's like with any treatment that it gets better, worse, then better and worse again?? So one day it works and other days it doesn't work? I try to use it every few weeks or something like that. But this is my experience. maybe other will react very different.



Post Ghost on Sat Nov 22, 2014 11:28 am

Gonzo wrote:
Last night I tried 7.5 mg Loratadine just for the hell of it. Thought that it couldn't hurt, and if anything may help me sleep better...Oddly enough...I slept worse...I woke up in the middle of the night, and didn't sleep in as long this morning. I found this very odd, because one of the side effects is drowsiness. As noted about, Loratadine is a H1 antagonist...but I thought something that area said before could possibly relate...he'd know best on this... "IF YOU ARE PRONE TO INSOMNIA (Which I kinda am occasionally)...DO NOT OR TREAD CAREFULLY TAKING HISTAMINE H3 BLOCKERS"...Is it possibly that a H1 blocker caused me some trouble sleeping? I think that I will try another 7.5mg this morning, and no longer take it at night. Also, the shit expired in 2012, so I'm gonna head to the store and buy me some new Claritin. Also interesting is that on the wikipedia page (sorry for sourcing wikipedia again) it had this to say... "In structure, it is closely related to tricyclic antidepressants"... I found that somewhat interesting...I plan on trying this for the next couple of days just to see what happens. Can't go too wrong in my opinion. I'd rather take my chances going "Claritin clear" than with another drug to try and treat this. I'll keep you posted.

edit: I used to have very hot/ sweaty feet. It was really annoying because I had to change socks a lot. After lexapro, my feet are never as sweaty or hot...which has been nice really. This morning they are sweaty and hot again. Coincidence? only time will tell. I'd trade that for my sex life back anyday. Very Happy

If the Loratadine expired in 2012, I think that it didn't make almost any effect at all, or a considerably reduced effect. I don't think that the insomnia was caused by loratadine. At least for me is the only drug that doesn't have any side effect.

Also,, if I take loratadine alone, it doesn't do anything and the same with levitra (or vagra or cialis). But if I take both together = Automatic erection. It's amazing. But I recomend you trying it for sex, because if you use it 2-3 days in a row, I think that it's not going to work. Or maybe it's like with any treatment that it gets better, worse, then better and worse again?? So one day it works and other days it doesn't work? I try to use it every few weeks or something like that. But this is my experience. maybe other will react very different.

Yea I figured it may not have been as good if it was old. I got some 10mg stuff today. Took 5mg at breakfast and will take 5mg at dinner. My goal is to reduce histamine levels throughout the entire day, and hopefully improve things in that way. Gonzo, maybe try a low dose of Berberine along side of the Loratadine...that's a PDE-5 inhibitor like the ED medication...If you permanently down regulated PDE-5 expression...you should have those AMAZING erections whenever you take Loratadine. But this is more of Area'a hypothesis, and I'll see if he explains it better. My berberine got lost in the mail, so I currently have none to try it with. I'd maybe give it a shot if I were you.


Post catalunya on Sat Nov 22, 2014 3:53 pm

the drug was fine even if expired - http://www.health.harvard.edu/fhg/updat ... 103a.shtml



Post Ghost on Sun Nov 23, 2014 9:17 pm

Been almost 2 days since first taking Loratadine. I've taken a total of 22.5 mg over 48 hr course. It may have helped erections minimally, possibly helping with blood flow in the tip of my penis. I seemed to be able to get erections faster today. Maybe. No improvement in genital numbing. I'll try it for a few more days just in case. I think that histamine H1 blocker + PDE-5 inhibitor is very good info for someone to use if in a pinch.



Post forexworld12 on Sun Nov 23, 2014 11:33 pm

Ghost wrote:Been almost 2 days since first taking Loratadine. I've taken a total of 22.5 mg over 48 hr course. It may have helped erections minimally, possibly helping with blood flow in the tip of my penis. I seemed to be able to get erections faster today. Maybe. No improvement in genital numbing. I'll try it for a few more days just in case. I think that histamine H1 blocker + PDE-5 inhibitor is very good info for someone to use if in a pinch.

Loratadine only will help you with getting good erections .. it won't help numb gentials my friend !

Viagra could be very dangerous. Better use some natural ED supplements. You can read about ED drugs side effects here - https://eddrugs2017.com.
You can also try for erectile dysfunction issues forskolin.
https://forskolin.reviews:
"Plecreanthus barbatus, or Coleus foskohlii, has a history of traditional Asian medicinal usage dating back to ancient times. These traditional uses claim the plant is effective for treating rashes, insomnia, epilepsy, asthma, bronchitis, high blood pressure, and chest pain.

Although forskolin is currently marketed heavily by the weight-loss industry, there are many other possible uses that are currently being researched. These uses include treatment of allergies, angina, asthma, blood clots, cancer, convulsions, eczema, erectile dysfunction, glaucoma, irritable bowel syndrome (IBS), insomnia, psoriasis, and urinary tract infections.:
And some testosterone boosters with fenugreek can help.
https://naturaltestosteronepills.com:
"Testosterone and estrogen are the main sex hormones. Both men and women produce testosterone, but men make more. Women produce more estrogen than men.

Testosterone makes male sex organs grow when boys are developing. It also supports male physical attributes such as facial hair growth, broader shoulders, and denser muscle development.

Sexual excitement is caused in part by a rise in testosterone, though other factors contribute. Testosterone levels rise and fall throughout the day. Some men notice they are more excitable when testosterone is high, which is usually in the mornings.

Testosterone levels also fluctuate over your lifespan and start to decline after age 30. This could mean a man has less interest in sex later in life, and possibly less firm erections as well as softer muscle tone."

saw this on another forum, possible PSSD treatment?

"About 12 months ago, one of my male clients with major depression who previously had experienced sexual dysfunction with fluoxetine, 5 mg/day, restarted taking fluoxetine, 5 mg/day, while also taking loratadine, 2.5 mg/day, for allergic rhinitis....Whereas before with fluoxetine he had reported dulling of penile sensation and delayed erection and ejaculation, in the presence of loratadine none of these side effects were present and he reported normal sexual function, which continued at last report.

Due to this initial success with loratadine, over the next 9 months I prescribed, with informed consent, loratadine for fluoxetine-induced sexual dysfunction in 9 additional patients (5 men and 4 women) with a diagnosis of major depression. Seven of 9 patients had complete reversal of sexual dysfunction within 2 days, and the other 2 experienced significant improvement of sexual side effects. One male patient, who had partial impotence and low libido, had function restored to a prefluoxetine state by taking loratadine, 10 mg, 1 day before planned sexual activity. Side effects of loratadine ranged from none to mild-to-moderate dry mouth and sedation, which responded to bedtime dosing or reduction in dose. No change was seen on effectiveness of fluoxetine for depression, although the patients were happy to have their sexual function restored.

Furthermore, a female patient taking nefazadone and sertraline responded nicely to the addition of loratadine for low sexual interest and anorgasmia. I also prescribed loratadine for low sexual interest and anorgasmia to a female patient taking paroxetine and a male patient experiencing impotence who was being treated with citalopram, but neither had a positive response. I have no explanation for this lack of efficacy."

"Nine patients diagnosed as major depressive disorder (MDD), with erectile dysfunction associated with the administration of SSRIs, completed a 2-week trial of loratadine in the dose of 10 mg/day....Subjects had statistically significant improvement in their erectile functions and 55% reported subjective improvement of the erectile function....Our findings suggest the possible role of loratadine in the treatment of SSRI-associated sexual dysfunction. They are promising, but preliminary. Thus they should be replicated in a longer large-scale, double-blind, placebo-controlled trial."

"I began to suffer Stuffy nose. It's a nasty side effect from [levitra]....I took 20mg of levitra together with Loratadine to counteract the stuffy nose. And about 40 minutes later, I started to have a hard rock erection, just with my libido and nothing else, no other stimulation. I almost couldn't stop the erection during 4 hours!... This is so weird. This is the first time since PSSD that I have to fight to stop an erection!. (Aside from my priapism induced by Trimix)...Levitra alone doesn't work for the erection! I've tried it thousand of times without success. Loratadine does something! It can't be coincidence. Although No effect over the anesthesia and orgasm."

"Loratadine exposed males with and without hypospadias had significantly higher levels of androgen receptor mRNA expression than the male controls."

"Loratadine exposed males with hypospadias exhibited a significant increase in estrogen receptor mRNA expression compared to control males. However, loratadine exposed males without hypospadias were no different from control males. Levels of estrogen receptor mRNA did not change in any group as a result of exposure to loratadine (data not shown)."

"As commonly occurs, not all male mice in this study had development of hypospadias. This outcome is probably attributable to the fact that hypospadias is most likely under multifactorial influence, and that some individuals are predisposed to environmental influence.1 The mouse strain used in this study (CD1) has been identified as one of the least susceptible to estrogenic disruption.10 Loratadine shares some characteristics with compounds known to act as antiandrogens, including a similar motif of a halogenated carbon ring. In the case of p,p=-DDE, procymidone and loratadine, among others, the halogen is chlorine. Previous research with the rat has demonstrated that p,p=-DDE and procymidone cause hypospadias.11"

"The effect of loratadine exposure on steroid receptor mRNA expression followed a clear pattern of producing female-like results in exposed males, and also exhibited a pattern of more extreme response in males with hypospadias. These results are similar to those observed following exposure to a known estrogen. Ethinyl estradiol exposure results in outcomes similar to those identified in this study at all levels of assessment, including mRNA (unpublished data), and macroscopic and histological morphology.2 Exposure to this synthetic estrogen with the same regimen used for loratadine in this study resulted in an increase in androgen receptor mRNA expression and in estrogen receptor expression (unpublished data)."

Sound really interesting!

Very interesting, but not an entirely new idea: https://area1255.blogspot.nl/2017/09/in ... -post.html
Maybe it helps some people, seems very safe to use.

I've taken Loratadine in the past and it doesn't work for me.

Good find. This is from 2014 on the forum. I'll merge the topics

viewtopic.php?f=20&t=184&p=997&hilit=loratadine#p997

If an antihistamine does this, can not it mean that pssd has a lot of autoimmune problem?

Wanted to update you all with my log, which was posted on hackstatic-forum first:

March 11 2018:
Ive been using it some 5 days now, and i actually get some results.
My morning wood is back and my brain fog is definately less pronounced (If anything i feel more active, not more sedated as one would expect with anti-histamines). It very much reminds me of Buspar (which i used after getting PSSD).
No impact on libido though, but i have an increased pressure on my throat, which i had before when i took SJW, which gave me a window. (still dont know what this means however).
Note that buspar is often used to decrease the sexual side-effects of SSRI's, maybe this is simular. I am not sure if the articles is taking about side-effects by SSRI usage, or PSSD, this could be something similar.
Anyway, ill try it for about 2 weeks, as it is safe, OTC, cheap and without any side-effects.

March 15:
Im at day 9 now, upped to dosage to 20mg/day since day 8. Doesnt seem to make me tired/dull.
Surprisingly, i feel i make small steps forward every day! I estimate i am at 50% now so too soon to tell, but this really does something. Both Emotions and libido are up.

March 19:
Almost done with the 2weeks. Minor impact on libido, but brain fog is almost gone and it seems to have cured my PE that i developed in the last 6 months. Also felt bit more emotions, even stress (although not always rationale, like it wants out after 2 years of ignoring it)
Going to see if this lasts when i stop taking it. Overall pretty good stuff but far from a cure, at least at this dose for 2 weeks.