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Re: Stool Test [E Histolytica]

Unread postPosted: Sat Aug 11, 2018 1:29 am
by Fester
Your result sheet looks very similar to these sample results from the Diagnostic Solutions GI-Map test: https://www.diagnosticsolutionslab.com/ ... t-2018.pdf

The guy in the post you quoted said he got a FilmArray GI Panel. I didn't find that test specifically, but searching the details of it is how I found the GI-Map test, which appears to be similar. Costs about 300 GBP here though, yikes.

Even after a positive result my concern is the lab could miss the same parasite on a follow-up exam and falsely assume it was eradicated. Also people might attribute improvement to one pathogen when it was due to an unidentified one that got killed in the crossfire. Tricky when the symptoms can be so vague.

Re: Stool Test [E Histolytica]

Unread postPosted: Sat Aug 11, 2018 4:47 am
by raven100
Fester wrote:Your result sheet looks very similar to these sample results from the Diagnostic Solutions GI-Map test: https://www.diagnosticsolutionslab.com/ ... t-2018.pdf

The guy in the post you quoted said he got a FilmArray GI Panel. I didn't find that test specifically, but searching the details of it is how I found the GI-Map test, which appears to be similar. Costs about 300 GBP here though, yikes.

Even after a positive result my concern is the lab could miss the same parasite on a follow-up exam and falsely assume it was eradicated. Also people might attribute improvement to one pathogen when it was due to an unidentified one that got killed in the crossfire. Tricky when the symptoms can be so vague.


Ah yeah it's diagnosticsolutionslab, my pathogen levels were so high that you couldn't miss them, 4 orders of magnitude outside normal range

Re: Stool Test [E Histolytica]

Unread postPosted: Sat Aug 11, 2018 8:20 am
by Timm Thaler
raven, may I ask: do you suffer from diarrhea? Is this necessarily a key symptom? I kind of suspect something isn't right with me with my congestional system, however I never suffer from diarrhea rather the contrary.

Re: Stool Test [E Histolytica]

Unread postPosted: Sat Aug 11, 2018 9:13 am
by raven100
Timm Thaler wrote:raven, may I ask: do you suffer from diarrhea? Is this necessarily a key symptom? I kind of suspect something isn't right with me with my congestional system, however I never suffer from diarrhea rather the contrary.


I occasionally suffer very mild digestive symptoms, all very subtle, I really think everyone should get a comprehensive stool test, in the vast majority of cases with this parasite the patient is asymptomatic, yet the parasite will still be artificially raising the level of serotonin in the gut.

Re: Stool Test [E Histolytica]

Unread postPosted: Sat Aug 11, 2018 11:02 am
by Ghost
Brilliant Raven, great work.

Read this: https://pssdlab.wordpress.com/2018/08/1 ... ry-foiled/

My test didn't include it. Darn. I'll have to get another one. I know that the user Brooks has one in the mail right now that he finished.

Re: Stool Test [E Histolytica]

Unread postPosted: Sat Aug 11, 2018 1:52 pm
by raven100
Ghost wrote:Brilliant Raven, great work.

Read this: https://pssdlab.wordpress.com/2018/08/1 ... ry-foiled/

My test didn't include it. Darn. I'll have to get another one. I know that the user Brooks has one in the mail right now that he finished.


Oh wow, hadn't even seen all this stuff you've been posting, have to catch up (https://pssdlab.wordpress.com/logging/)

Will be very interesting to see if some of you guys have it too. If anything I think E Histolytica is more likely to be the cause of PSSD than PFS in some people, given the Serotonin link.

Re: Stool Test [E Histolytica]

Unread postPosted: Sat Aug 11, 2018 4:35 pm
by Ghost
Yep I've been spending most of my energy there in recent weeks.

Re: Stool Test [E Histolytica]

Unread postPosted: Sun Aug 12, 2018 12:02 am
by north4

Re: Stool Test [E Histolytica]

Unread postPosted: Sun Aug 12, 2018 1:47 pm
by raven100
north4 wrote:https://www.ncbi.nlm.nih.gov/pubmed/?term=histolytica+serotonin


interesting stuff

Re: Stool Test [E Histolytica]

Unread postPosted: Thu Aug 23, 2018 11:11 am
by iii1i1i1
https://books.google.pl/books?id=InIVDAAAQBAJ&pg=PA42&lpg=PA42&dq=serotonin+parasites&source=bl&ots=Ijpxi6XAMT&sig=6ew0jWQzqr7-G2XXLB-mG-0GNoE&hl=pl&sa=X&ved=2ahUKEwiW_rTD8ujcAhUDYpoKHcl8B-E4ChDoATABegQICRAB#v=onepage&q=serotonin%20parasites&f=false:

"The evidence (...) suggests that manipulation of the host's serotonergic neuromodulatory system is involved"
"Only those parasitic infections that alter host serotonergic systems have an effect on host phototactic behavior"
"The greater the increase in serotonergic immunohistochemical staining within the central nervous system, the greater is the change in host behavior"
"Moreover, injecting serotonin can mimic some of the effects of parasitism and this effect is specific for serotonin; injections of other biogenic amines do not produce these effects in Gammarus lacustris"
"An injection of serotonin not only increases movement towards the light in uninfected animals, it also augments it in parasitized animals"
"Immersion in the serotonin reuptake inhibitor, fluoxetine, increases phototaxis in a related crustacean"
"Furthermore, serotonin has been shown to induce relatively specific behavioral changes in other crustacea"
"Biogenic amines like serotonin typically have broad connections connections throughout the invertebrate central nervous system"
"They are thought to modulate the likelihood of producing different behaviors given the right context"
"Mimicking the effect of parasitism in gammarids requires injections of supraphysiological levels of serotonin, resulting in concentrations 1,000 to 10,000 times above the likely physiological concentration. Such levels would be difficult for either host or parasite to synthesize and maintain. Furthermore, when crayfish are infused with high doses of serotonin for an extended period of time, the central nervous system adapts, and the elevated serotonin loses its behavioral effectivenss"
"the injection studies suggest that serotonin release is increased in parasitized hosts."
"Tain et al. (2007) suggest that infection induces a massive increase in serotonin synthesis, leading to both increased staining and increased release"
"the parasite could secrete a compound that induces long-term activation of host serotonergic receptors. Such a compound would probably decrease the release of the host's own serotonin, leading to increased immunohistochemical staining, while at the same time increasing activity in host's serotonergic system"


https://www.ncbi.nlm.nih.gov/pubmed/16886365:
"The results were compared to the values obtained in the control group of 10 healthy children, 3-12 years old. III children were divided into two groups: first consisted of 12 children, 2-5 years old, second--of 12 children, 6-12 years old. In the first group 210% increase of the serotonin level in the blood and slight 32,4% increase of the MAO activity were observed in comparison with the control group. In the second group the serotonin level in the blood increased 221% in comparison with the control, while the MAO actmty increased 45.1%."

https://books.google.pl/books?id=LhvSBwAAQBAJ&pg=PA222&lpg=PA222&dq=serotonin+lamblia&source=bl&ots=3lhBnBKuyN&sig=r9pJMXkmL6zJ5iYR4icUeq0Wl3k&hl=pl&sa=X&ved=2ahUKEwiqs4XNkYLdAhXGk4sKHUqGDN4Q6AEwBHoECAYQAQ#v=onepage&q=serotonin%20lamblia&f=false
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679081/
https://www.ncbi.nlm.nih.gov/pubmed/8500845
https://www.ncbi.nlm.nih.gov/pubmed/2561282
https://www.ncbi.nlm.nih.gov/pubmed/21327112
https://www.ncbi.nlm.nih.gov/pubmed/6308760
https://www.ncbi.nlm.nih.gov/pubmed/2155844
https://www.ncbi.nlm.nih.gov/pubmed/2861068
https://www.researchgate.net/publication/20595436_Effect_of_exogenous_5-hydroxytryptamine_on_pathogenicity_of_Entamoeba_histolytica_in_experimental_animals
https://www.ncbi.nlm.nih.gov/pubmed/21327112

https://www.ncbi.nlm.nih.gov/pubmed/6088956:
"The detection of serotonin: an additional approach in diagnosing amebiasis.
The diagnosis of amebiasis is often difficult and time consuming. Entamoeba histolytica has been shown to contain serotonin. This fact might be exploited in the clinical setting. Assaying for serotonin may provide valuable diagnostic information."