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Re: Jaxx's pramipexol log

Unread postPosted: Sun Jan 06, 2019 7:02 am
by taarn
I'm also a bit blunted the day after melatonin. It's most probably because the dopamine inhibition.
https://www.ncbi.nlm.nih.gov/pubmed/12043836

Re: Jaxx's pramipexol log

Unread postPosted: Fri Jan 11, 2019 2:59 pm
by Jaxx
Took me a small week to bounce back from a dose of melatonin, will not touch that stuff anymore! (reminds me a bit of Pete's story though, but dose might have been too big already).
Starting with new cycle today: Kudzu + prami 0,25 (0,5 next week). Kudzu should antagonise Gaba and according to some sources even antagonise serotonin. However it is also pro-estrogen so it might not help in the end, time will tell.
Will try to update after 3 days again.

Re: Jaxx's pramipexol log

Unread postPosted: Fri Jan 11, 2019 4:15 pm
by Jaxx
zadig777 wrote:
Jaxx wrote:Took me a small week to bounce back from a dose of melatonin, will not touch that stuff anymore! (reminds me a bit of Pete's story though, but dose might have been too big already).
Starting with new cycle today: Kudzu + prami 0,25 (0,5 next week). Kudzu should antagonise Gaba and according to some sources even antagonise serotonin. However it is also pro-estrogen so it might not help in the end, time will tell.
Will try to update after 3 days again.


keep up the good work jaxx!
i will be trialing all of these drugs in the next months so we will see what happens:
-piribedil(trivastal)
-pramipexole
-ropinirole
-bromocriptin
-cabergoline
-clomifene(clomid)
-anastrazole(arimidex)
-hydrocortisone
-triiodothyronine (T3) thyroid hormone
-reboxetine(edronax)
-dextroamphetamine

ramp up the prami we shall prevail!


Like i said, we need people trialing stuff and reporting back, but that is a looong list mate. Cant really combine most of them id say.
Part of a successful test is trying it clean and for a long enough period, IMHO.

For your case, id say reboxetine (noradrenaline) or a gaba antagonist (perhaps imipramine, might be tricky as it also has serotonin activity?) would make sense.
How did you come to all the others?

Re: Jaxx's pramipexol log

Unread postPosted: Fri Jan 11, 2019 4:37 pm
by Jaxx
Real gaba antagonists can induce seizures, i need to do my homework to explore that properly.
And yeah, imi and reboxetine carry risks i agree. Reboxetine gave sone people premature ejaculation, but as your issue seems to be quite the opposite it might be worth a try at some point.

Re: Jaxx's pramipexol log

Unread postPosted: Mon Jan 14, 2019 10:02 am
by Jaxx
Day 3 on prami/kudzu. Having decent morning wood, and brain fog disappeared again.
Not sure if Kudzu is doing anything, but the 0,25mg prami only gave me real side-effects on day 1 (headache, shallow sleep), but seems fine now. Will up the dose in half a week, both on prami and on kudzu root.

Re: Jaxx's pramipexol log

Unread postPosted: Mon Jan 14, 2019 1:07 pm
by JayR
Jaxx wrote:Day 3 on prami/kudzu. Having decent morning wood, and brain fog disappeared again.
Not sure if Kudzu is doing anything, but the 0,25mg prami only gave me real side-effects on day 1 (headache, shallow sleep), but seems fine now. Will up the dose in half a week, both on prami and on kudzu root.

Kudzu root to antagonize GABA and disinhibit Dopamine? Or for the 5-HT2C-properties?

Re: Jaxx's pramipexol log

Unread postPosted: Mon Jan 14, 2019 1:20 pm
by Jaxx
JayR wrote:
Jaxx wrote:Day 3 on prami/kudzu. Having decent morning wood, and brain fog disappeared again.
Not sure if Kudzu is doing anything, but the 0,25mg prami only gave me real side-effects on day 1 (headache, shallow sleep), but seems fine now. Will up the dose in half a week, both on prami and on kudzu root.

Kudzu root to antagonize GABA and disinhibit Dopamine? Or for the 5-HT2C-properties?

Antagonize Gaba is the basic idea, might switch to ginkgo if i dont get results in 2/3 weeks.

Re: Jaxx's pramipexol log

Unread postPosted: Mon Jan 14, 2019 5:11 pm
by GIXXER
Im currently on 10mg imipramine. I was 20 mg for a few weeks but I felt it was making things worse so I tapered back down to 10mg. Im plan on coming off all together.

Re: Jaxx's pramipexol log

Unread postPosted: Mon Jan 14, 2019 8:15 pm
by sovietxrobot
Jaxx wrote:Took me a small week to bounce back from a dose of melatonin, will not touch that stuff anymore! (reminds me a bit of Pete's story though, but dose might have been too big already).
Starting with new cycle today: Kudzu + prami 0,25 (0,5 next week). Kudzu should antagonise Gaba and according to some sources even antagonise serotonin. However it is also pro-estrogen so it might not help in the end, time will tell.
Will try to update after 3 days again.


thats interesting. I have a lot of evidence to suggest that PSSD in my case is related to low dopamine. Yet, I have a positive reaction to melatonin, and feel noticeable more flat and irritable if I don't take it. Similarly, yohimbine is supposedly a d2-dopamine antagonist, yet it gives me a noticeable boost.

I've been trying large doses dopa mucuna, which has some similarities to pramipexol. Its been shown to be at least as effective as levodopa in treating Parkinson's disease. Its given me a big boost in concentration and motivation, and a moderate boost in libido. I had a great window where I was close to feeling passion and desire again.

Re: Jaxx's pramipexol log

Unread postPosted: Sun Jan 20, 2019 6:29 am
by Jaxx
2nd day on 0,5mg prami and 2 pills kudzu daily. morning wood is good, energy is better. No impact on libido but id like to give it more time. sleep is so so, but as the energy isok when i wake up it really isnt an issue. also no headaches anymore, which was my most important side effect.