Page 1 of 1

Some libido back from megadose Buspirone, Weed

Unread postPosted: Mon Apr 15, 2019 11:35 am
by Animus
100 mg (10 pills) buspirone + a little hybrid/sativa weed = some libido back for an hour or two, can have a nice fap.
I also smoke tobacco, pack a day, which as you probably know contains an MAOI, so that may be a factor, idk.
Worth a try, if you're frustrated. And unlike stimulants which, no surprise, work for me too, this does not give me a stim-dick.

Re: Some libido back from megadose Buspirone, Weed

Unread postPosted: Mon Apr 15, 2019 11:41 am
by TalkingAntColony
Be careful with buspirone. Some people here react negatively. The main effects supposedly take a few weeks to kick in, so I'm not sure acute effects are going to be helpful. If I take even 5mg of buspirone, I get dizzyness that feels similar to SSRI-withdrawal brain zaps, which lasts for about an hour. If I took 100mg at once, I would probably feel pretty bad. I tried taking it for a few weeks and nothing happened except the acute dizzyness reduced slightly.

Re: Some libido back from megadose Buspirone, Weed

Unread postPosted: Mon Apr 15, 2019 12:17 pm
by Snake
TalkingAntColony wrote:Be careful with buspirone. Some people here react negatively. The main effects supposedly take a few weeks to kick in, so I'm not sure acute effects are going to be helpful. If I take even 5mg of buspirone, I get dizzyness that feels similar to SSRI-withdrawal brain zaps, which lasts for about an hour. If I took 100mg at once, I would probably feel pretty bad. I tried taking it for a few weeks and nothing happened except the acute dizzyness reduced slightly.


Yes, be careful, in my case PSSD + buspirone was like atom bomb and gave me additional persisting symptoms.

Re: Some libido back from megadose Buspirone, Weed

Unread postPosted: Mon Apr 15, 2019 11:18 pm
by Mesolimbo
Buspirone's main metabolite, 1-PP, is an alpha2-adrenergic receptor antagonist. This causes dopamine, norepinephrine, and nitric oxide release. This is the most likely cause for the improved sexual function you have experienced.

Buspirone, at high doses, is a dopamine D2-family receptor antagonist and 5HT2 antagonist. I guess the tobacco and the 1-PP had overriden the dopamine antagonism with some help from 5HT2C antagonism.

There's a little bit of polypharmacy here, so it's hard to pinpoint what helped the most.

Re: Some libido back from megadose Buspirone, Weed

Unread postPosted: Mon Apr 15, 2019 11:19 pm
by Animus
Don't know about you guys, but my symptoms are severe enough that it can't get any worse really.
There are remedies, all strong aphrodisiacs (e.g. amphetamines) make me horny again, but if you stay afraid, then there really is no solution.