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Re: Attempting to cure/reverse my own PSSD

Unread postPosted: Wed May 15, 2019 8:35 pm
by taarn
Mesolimbo wrote:I'll try again tomorrow, if I get less effects from Baclofen, then it's time to add SJW for postsynaptic 5HT1A upregulation. I may even consider ditching Baclofen and getting my GR downregulation some other way.

For resensitizing 5-HT1A it seems to be logical to lessen activation on it as much as it's possible, isn't it?
I'm also thinking if I should get off Bupropion in order to make SJW more effective at resensitizing the postsynaptic receptors. I'm not sure if it's a good idea though.

Re: Attempting to cure/reverse my own PSSD

Unread postPosted: Thu May 16, 2019 12:45 am
by Mesolimbo
taarn wrote:
Mesolimbo wrote:I'll try again tomorrow, if I get less effects from Baclofen, then it's time to add SJW for postsynaptic 5HT1A upregulation. I may even consider ditching Baclofen and getting my GR downregulation some other way.

For resensitizing 5-HT1A it seems to be logical to lessen activation on it as much as it's possible, isn't it?
I'm also thinking if I should get off Bupropion in order to make SJW more effective at resensitizing the postsynaptic receptors. I'm not sure if it's a good idea though.

SJW alone isn't enough to have postsynaptic 5HT1A activation. You need to desensitize the presynaptic autoreceptors or this whole thing is pointless since autoreceptors inhibit serotonin release to postsynaptic ones.

Vortioxetine makes tolerance to Baclofen rapid despite Memantine for the simple reason that it's a full 5HT1A agonist. I think I should be getting enough postsynaptic 5HT1A activation with Vortioxetine + SJW, hence thinking about quitting Baclofen. I'm more interested in baseline improvement without feeling like I'm "on" something and then crashing by the end of the day.

If I decide to go down this route, regimen would look like this:
- Vortioxetine: 5 mg
- Metformin: 500 mg
- SJW: 300-600 mg
- Licorice extract or a corticosteroid: for GR downregulation.

This should make my baseline better without inducing tolerance.

Re: Attempting to cure/reverse my own PSSD

Unread postPosted: Thu May 16, 2019 4:07 am
by Radar
What dose Licorice Root extract would you consider taking? Perhaps very low doses might be enough for GR downregulation without suffering too much of the estrogenic effects?

Re: Attempting to cure/reverse my own PSSD

Unread postPosted: Thu May 16, 2019 4:11 am
by Mesolimbo
Radar wrote:What dose Licorice Root extract would you consider taking? Perhaps very low doses might be enough for GR downregulation without suffering too much of the estrogenic effects?

I still haven't decided on changing my regimen. I'll try Baclofen today, maybe the diminished effect was only a 1-time thing due to poor sleep.

If I decide on quitting Baclofen + Memantine, then low dose licorice, yes.

Re: Attempting to cure/reverse my own PSSD

Unread postPosted: Thu May 16, 2019 6:57 am
by Mesolimbo
I confirm that I have become a little tolerant to Baclofen's effect. Therefore, I've decided to ditch both Baclofen and Memantine, and instead adding SJW and licorice root.

Mesolimbo wrote:If I decide to go down this route, regimen would look like this:
- Vortioxetine: 5 mg
- Metformin: 500 mg
- SJW: 300-600 mg
- Licorice extract or a corticosteroid: for GR downregulation.

This should make my baseline better without inducing tolerance.

Re: Attempting to cure/reverse my own PSSD

Unread postPosted: Sat May 18, 2019 2:54 am
by Hope
Hi Mesolimbo, how it's going with added SJW and Licorice? What dosage are you taking of the latter?

Mesolimbo wrote:I confirm that I have become a little tolerant to Baclofen's effect. Therefore, I've decided to ditch both Baclofen and Memantine, and instead adding SJW and licorice root.

Mesolimbo wrote:If I decide to go down this route, regimen would look like this:
- Vortioxetine: 5 mg
- Metformin: 500 mg
- SJW: 300-600 mg
- Licorice extract or a corticosteroid: for GR downregulation.

This should make my baseline better without inducing tolerance.

Re: Attempting to cure/reverse my own PSSD

Unread postPosted: Sat May 18, 2019 3:10 am
by Mesolimbo
Hope wrote:Hi Mesolimbo, how it's going with added SJW and Licorice? What dosage are you taking of the latter?

SJW have restored my response to postsynaptic 5HT1A agonism. I re-tried Baclofen and it works again, so SJW practically reversed my tolerance to it within 2 days. I make a tea out of licorice root, 3 g. It's not standardized and I feel it's pretty weak, so I've been trying various doses of Prednisolone instead, but I won't go into details because I don't feel comfortable discussing a drug this dangerous/risky on the forum without completing the entire trial through.

SJW is definitely a step on the right direction, I feel really great on this regimen, but Vortioxetine is still making me very tired. I should adapt soon, though. This is my 16th day.

Re: Attempting to cure/reverse my own PSSD

Unread postPosted: Sat May 18, 2019 4:41 am
by Hope
Mesolimbo wrote:
Hope wrote:Hi Mesolimbo, how it's going with added SJW and Licorice? What dosage are you taking of the latter?

SJW have restored my response to postsynaptic 5HT1A agonism. I re-tried Baclofen and it works again, so SJW practically reversed my tolerance to it within 2 days. I make a tea out of licorice root, 3 g. It's not standardized and I feel it's pretty weak, so I've been trying various doses of Prednisolone instead, but I won't go into details because I don't feel comfortable discussing a drug this dangerous/risky on the forum without completing the entire trial through.

SJW is definitely a step on the right direction, I feel really great on this regimen, but Vortioxetine is still making me very tired. I should adapt soon, though. This is my 16th day.


Sounds great, thank you. I'll try to add low dose SJW and Licorice Extract to my Vortioxetine regimen.

Hold on, tiredeness will fade away once fully adapted!

Re: Attempting to cure/reverse my own PSSD

Unread postPosted: Sat May 18, 2019 9:34 am
by succubus76
Do you think we have free will mesolimbo? Is kinda funny how chemicals in our brain,of wich we have no control, determine how we feel and how we act. This mechanis were created through millons of years in different species, and they still remain to this day because they were the only ones that served for survival and reproduction. Could you imagine how many brain mechanism could exist that allow us to feel emotions and sensations that we cant even imagine?

P. S. Activation of 5hta1 make you feel horny? Im gonna guess you still have soft glands and numb genitals, they seem to operate via other mechanism.

Libido works throught other mechanism? The brain is very complicated! :D

Re: Attempting to cure/reverse my own PSSD

Unread postPosted: Sat May 18, 2019 9:43 am
by Snake
succubus76 wrote:Do you think we have free will mesolimbo? Is kinda funny how chemicals in our brain,of wich we have no control, determine how we feel and how we act. This mechanis were created through millons of years in different species, and they still remain to this day because they were the only ones that served for survival and reproduction. Could you imagine how many brain mechanism could exist that allow us to feel emotions and sensations that we cant even imagine?

P. S. Activation of 5hta1 make you feel horny? Im gonna guess you still have soft glands and numb genitals, they seem to operate via other mechanism.

Libido works throught other mechanism? The brain is very complicated! :D


Yep, it's really a food for thought. Those imbalances seem to determine almost everything that we feel/do. Where is the space for free will there?