taarn wrote:@Psychogenesis why are you so sure Nandrolone downregulates AR? As far as my readings go, T and androgenic steroids upregulate AR expression in the hypothalamus, especially the mPOA. They restored AR expression in rat's mPOA after castration, it took 3 weeks.
Also I think we can't be sure about AR/ER ratio, probably those two are downregulated/silenced.
For example IGF-1 seems to activate AR signaling, maybe combining androgens with IGF-1 would do something, or IGF-1 by itself. But real IGF-1 is very expensive, and kinda dangerous.
https://www.ncbi.nlm.nih.gov/pubmed/17202144
Also I was considering adding progesterone antagonists to androgens.
Additionally, my friends who took stanozolol + T propionate became very horny and had something called "super-orgasm". They said the super orgasm mostly remained even after finishing the cycle, that means permanently upregulated AR imo.
But anyway, hats off to you, I was considering doing something similar, with some other twists.
For example IGF-1 seems to activate AR signaling, maybe combining androgens with IGF-1 would do something, or IGF-1 by itself. But real IGF-1 is very expensive, and kinda dangerous.
https://www.ncbi.nlm.nih.gov/pubmed/17202144
Jaxx wrote:I see a couple of threads in parallel, werent you also trying dxm?
taarn wrote:@Psychogenesis
People don't grow indefinitely because of the upregulation of myostatin in response to muscle growth, not because of AR silencing/downregulation.
Yes probably AR rebound can silence the AR signaling, but I still don't understand what would unsilence it. If you combine finasteride and nandrolone that would mean further bombing your AR with potent androgens.
About mk-677: Did you measure your IGF-1 levels? I think we need pharma grade IGF-1 and possibly high dose.
Another interesting fact is that I had above range IGF-1 levels when I checked, without taking steroids. Good question if it's simply downregulation or silenced signaling, or some mutated AR.
true that mk only increases igf withing the physiological range, only thing you can do is causing a shift in natural production with something like metformin but i don't put much faith on that
PsychoGenesis wrote:the plan is withdrawing finasteride after 4 weeks causing an aggressive shift, from high androgen to low androgen(exactly the opposite that fina with testosterone does)
I've done bloodwork couple months ago and dht was on the high end, test was not shutdown but was almost 100% freed up from shbgtaarn wrote:This plan actually presumes that 5-ar activity is still normal. What comes to my mind is that 5-ar can have a shift in affinity towards progesterone, or 5-ar levels can be reduced, and you won't get the normal amount of DHN. Testosterone won't do too much, cause natural T production is shut, right?
I don't want to criticize, don't get me wrong, I'm just thinking about possibilites.
Stanozolol also has a very low androgenic ratio, maybe we can go straight for stanozolol, without finasteride. Another thing I was thinking about is Enzalutamide, it even seems to have significant activity in CNS, blocking the AR in the brain would probably cause upregulation or restoration of signaling I guess.
I'm really curious about your results and hope it will work for you!
Mesolimbo wrote:Which location do you want to affect AR expression doing this? genital tissues? the hypothalamus? limbic system in general?
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