Lorcaserin 5ht2c agonist

[fellow1]

Have anyone tried to upregulate 5ht2c ? 5ht2c is proerectile receptor and I haven't seen someone explored this route. Does anybody can comment on safety profile of lorcaserin ?

Activation of 5-HT2C receptor subtype has been reported to mediate numerous effects, such as penile erection.[42][43] Based on multiple studies, results show that several 5-HT2C receptor agonists, including mCPP and YM348 induce penile erections in rats,[44] but mCPP seems to mimic both vasodilation and vasoconstriction. The vasodilator action is mediated by 5-HT1D receptors, whereas the vasoconstriction effect involves 5-HT2 receptor activation.[45] YM-348 is a highly selective 5-HT2C agonist and results show that YM348 can induce penile erections and hypolocomotion (induced at a high dose) in rats, as did other 5-HT2C receptor agonists. These effects were completely inhibited by a selective 5-HT2C receptor antagonist, SB-242,084. Therefore, results suggest that YM348 is a potent and orally active 5-HT2C receptor agonist.[46][47]


And another comments from selfhacked.com :

Activation of the 5-HT2C receptor helps men ejaculate and get hard [20, 1].
I wouldn’t be surprised if this receptor is part of long-term sexual dysfunction in men who take SSRIs

[tonyareias]

Conversely, many SSRIs (but not fluoxetine, which is a 5-HT2C antagonist[15]) indirectly stimulate 5-HT2C activity by increasing levels of serotonin in the synapse although the delayed mood elevation that is usually typical of SSRIs is usually paralleled by the downregulation of the 5-HT2C receptors. Wikipedia