started on sunday 24/11/2019
dose dxm 300mg naltrexone 25mg
day 1 - took dxm and naltrexone at the same time, I'm very dissociated
day 2 - same
day 3 - getting less dissociation, prolly because nalt is building up and inhibiting the dxm>dxo conversion(cyp2d6)> https://www.ncbi.nlm.nih.gov/m/pubmed/29744741/
http://media.corporate-ir.net/media_fil ... hl_5_3.pdf
and how do i know it's not tolerance to NMDA antagonism? because before starting this trial i tested 300mg + a low dose of naltrexone (5mg) and it blocked "dxm" effects
day 4 - very disphoric the moment when i wake up but then it subsides
day 5 - same, no dissociation even tho i dosed DXM earlier in the day
should i drop naltrexone maybe??
day 6 - dosed both at same time after breakfast
dissociation come and goes in waves couple hours in