Melatonin

[elkikko]

http://www.sciencedirect.com/science/ar ... 9300027153


Try melatonin?

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Have you tried it? It helps. In my first window I was previously taking 3 mg melatonin for some months

[elkikko]

Have you tried it? It helps. In my first window I was previously taking 3 mg melatonin for some months

What about zero libido improvments?....

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at that time I was not trying to cure PSSD, I was just thinking these were symptoms of hashimoto's hypothyroidism. I was taking a cocktail done by an orthomolecular physician (that was my last attempt of a doctor to cure my symptoms), and melatonin was a tiny part of it. I can't say what melatonin did by itself, because I was taking so many other stuffs together. According to exams, I had too much serotonin, adrenalin and cortisol, and too little dopamine. Melatonin is dopamine precursor (sertonin converts into melatonin that itself converts into dopamine), that's why I was taking it. If not libido, it probably can help with anhedonia. It's also an antioxidant, so it resensitizes and restores some parts of the brain. I started dreaming on melatonin, and then for a little more than one month after stop taking it I was still dreaming. Then it vanished.

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that's really not what my doctor would say. we started on melatonin mainly for getting more dopamine, because I refused taking bupropion or agomelatin, which were her first attempts. and whatever formula she did, after 2 months I was feeling good, no anhedonia, very high libido and the exams showed normal dopamine in my body. (but PSSD would persist: I know I wasn't working "normal". Also I had no morning woods, and no spontaneous erections.)

beware because researchs can have flaws. in fact, science has much more flaws than we can imagine, but we were not taught Science Philosophy to critically examine science and question its methodes. and medical decisions is not made based in only one research, for sure. dreaming has to do with the release of dopamine. bupropion is known to make people have vivid dreams, as I myself would have. mucuna also. and the melatonin made me dream again.

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I stopped taking it because a friend of mine got 95% cured from PSSD, and then I discovered the path for cure has nothing to do with these supplements. I wanted to get cured, and not to manage my PSSD. (and doctors's exams and supplements were HUGELY expensive!)

right now, I'm starting taking melatonin again (started last week), at least to see if it can manage my anhedonia. I'm also trying to get some stuffs my doctor had prescribed me in the past, in the month I was completely functional with very high libido, because I must at least manage PSSD while not getting cured.

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I also quit going to that doctor because I finally told her about PSSD, she said she never heard about it, she would consult a pshychiatrist friend of her, and then she came with the "News" that it doesn't exist, and it's psychological. she even said that was because I was getting older (I had just turned 29 at that time). that's why I quit, because I had much more hope with my friend who got 95% cured from PSSD with other stuffs.

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okay, "melatonin converts into dopamine" was a mis simplification of mine. why is REM increased through melatonin? REM is also increased through D2 agonism:
http://natalneuro.org.br/organizacao/ci ... 202006.pdf

"Conversely, mice acutely depleted of dopamine enter a different novel awake state characterized by spectral patterns of hippocampal local field potentials that resemble electrophysiological
activity observed during slow-wave sleep (SWS). This dopamine-depleted state is marked by an apparent suppression of SWS and
a complete suppression of REM sleep. Treatment with D2 (but not D1 ) dopamine receptor agonists recovers REM sleep in these mice"

Also, melatonin treats D2 blockage due to antipsychotic drugs:
http://www.ncbi.nlm.nih.gov/pubmed/12043836

"Melatonin appears to be effective in the treatment of tardive dyskinesia. a severe movement disorder associated with long-term blockade of the postsynaptic dopamine D2 receptor by antipsychotic drugs in schizophrenic patients."

This D2 receptor is related to spontaneous erection, desire and prolactin control.

despite that, I don't see melatonin as a cure for PSSD. I myself would have been cured. I also wouldn't recommend it. There was some damage in my sleep cycle after PSSD, and that's why I decided to take it again, being afraid of further damage in the antioxidant properties of my brain in the long run. But the things I did last year made me be able to dream everyday, even without any supps.

I'm really afraid of managing symptoms with another antidepressant. This can lead to further damage. If I had stopped taking antidepressants after the first crash with Prozac, I would be in a much better situation than now. I would only accept taking another antidepressant if it was a potencial cure for PSSD, like stablon. besides, there is an easy and immediate way to treat my anhedonia and zero libido, which is with that homeopathic cocktail I already mentioned.

in my first window with melatonin, I was taking also mucuna, yohimbe, wild yam, maca, crysin, phenilalanin, boron and MSM. I had tried to reproduce this window with only mucuna, yohimbe and maca, but didn't work. I don't think phenylalanin did anything, since I took tyrosin long term and it did nothing also. I just bought wild yam today, so let's see if it does something. It could even be that I had improvements due to MSM detoxification (it also improves dopamine neurons in brain -- people with Parkinson will experience much slower death of dopamine neurons while on MSM), since other people may have seen improvements with MSM. I never thought it was MSM, but it could be.

[Ghost]

okay, "melatonin converts into dopamine" was a mis simplification of mine. why is REM increased through melatonin? REM is also increased through D2 agonism:
http://natalneuro.org.br/organizacao/ci ... 202006.pdf

"Conversely, mice acutely depleted of dopamine enter a different novel awake state characterized by spectral patterns of hippocampal local field potentials that resemble electrophysiological
activity observed during slow-wave sleep (SWS). This dopamine-depleted state is marked by an apparent suppression of SWS and
a complete suppression of REM sleep. Treatment with D2 (but not D1 ) dopamine receptor agonists recovers REM sleep in these mice"

Also, melatonin treats D2 blockage due to antipsychotic drugs:
http://www.ncbi.nlm.nih.gov/pubmed/12043836

"Melatonin appears to be effective in the treatment of tardive dyskinesia. a severe movement disorder associated with long-term blockade of the postsynaptic dopamine D2 receptor by antipsychotic drugs in schizophrenic patients."


This D2 receptor is related to spontaneous erection, desire and prolactin control.

despite that, I don't see melatonin as a cure for PSSD. I myself would have been cured. I also wouldn't recommend it. There was some damage in my sleep cycle after PSSD, and that's why I decided to take it again, being afraid of further damage in the antioxidant properties of my brain in the long run. But the things I did last year made me be able to dream everyday, even without any supps.

I'm really afraid of managing symptoms with another antidepressant. This can lead to further damage. If I had stopped taking antidepressants after the first crash with Prozac, I would be in a much better situation than now. I would only accept taking another antidepressant if it was a potencial cure for PSSD, like stablon. besides, there is an easy and immediate way to treat my anhedonia and zero libido, which is with that homeopathic cocktail I already mentioned.

in my first window with melatonin, I was taking also mucuna, yohimbe, wild yam, maca, crysin, phenilalanin, boron and MSM. I had tried to reproduce this window with only mucuna, yohimbe and maca, but didn't work. I don't think phenylalanin did anything, since I took tyrosin long term and it did nothing also. I just bought wild yam today, so let's see if it does something. It could even be that I had improvements due to MSM detoxification (it also improves dopamine neurons in brain -- people with Parkinson will experience much slower death of dopamine neurons while on MSM), since other people may have seen improvements with MSM. I never thought it was MSM, but it could be.

@Continue, you seem to know a lot for a new member of the forum. Where do you get al this knowledge of D2 receptors and such?

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I think I read in some forum in the internet someone taking Cabergoline for treating PSSD. Cabergoline permanently upregulates D2 receptors, decreases prolactin, increases nocturnal and diurnal spontaneous erections. I never tried cabergoline, but it's something to consider. Also cabergoline is used in some PCT.