R. Damascena

[EricCartmanRJ]

Has anyone heard about this herbal agent ?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358691/

"With regard to improvements in sexual dysfunction, it is possible that agents of R. damascena oil have an antagonistic effect on the stimulation of the postsynaptic 5-HT2 and 5-HT3 receptors30–32 and that these agents have an antago nistic effect on the corticolimbic 5-HT receptors, which are responsible for increasing sexual desire, ejaculation, and orgasm.34,35 Additionally, it is possible that the agents of R. damascena agonistically increase the release of dopamine and norepinephrine in the substantia nigra,31,32 as well as disinhibiting nitric oxide synthase.33 Further, R. damascena oil seems to have an antimicrobial effect, and has been reported to protect neurons against amyloid β toxicity, a major pathological component of Alzheimer’s disease, and to protect rats against seizures. More specifically, it is suggested that the agent glycoside quercetin is also responsible for improving neuronal activity, probably by inducing the expression of synaptic proteins synaptotagmin and post-synaptic density protein-95, at least in cultured rat cortical neurons.65 Likewise, quercetin has been shown to reduce behavioral deficiencies, restore astrocytes and microglia, and reduce serotonin metabolism in a 3-nitropropionic acid-induced rat model of Huntington’s Disease.66 Last, Merzoug et al67 reported that quercetin mitigated Adriamycin-induced anxiety- and depression-like behaviors, immune dysfunction, and brain oxidative stress in rats.

With regard to the glycoside kaempferol, evidence from animal studies has shown an antidepressant and modulating effect on brain-derived neurotrophic factor and β amyloid in the neurons and hippocampus of double TgAD mice.68

Overall, research on animal models suggest that both quercetin and kaempferol, two of the main agents of R. damascena oil, seem to have beneficial influences on symptoms of depression at the molecular level.

Moreover, we also observe that explaining the occurrence and maintenance of MDD in terms of monoamine deficiency is just one of several putative pathways by which MDD might be explained neurophysiologically and neuroendocrinologically. In this regard, more recently efforts have been made to further investigate the roles of the neuropeptide brain-derived neurotrophic factor on MDD,10,69,70 on ketamine,71 and statins.72–75 With regard to statins, by using a mouse model, Ludka et al16 observed that after acute atorvastatin treatment, the antidepressant effect seemed to be explained via the L-argininenitric oxide-cyclic guanosine mono-phosphate pathway; atorvastatin seemed to inhibit NMDA (N-methyl-d-aspartatic acid) receptors and NO-cGMP (nitric oxide-cyclic guanosine monophosphate) synthesis, leading to a down-regulation of excitatory processes. On a behavioral level, this down-regulation seems to be reflected in a reduction of symptoms of depression. However, it remains unclear to what extent the new pathways explaining MDD neurophysiologically and neuroendocrinologically may help to better understand the influence of the agents of R. damascena oil on both symptoms of depression and sexual dysfunction."

[Ghost]

Has anyone heard about this herbal agent ?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358691/

"With regard to improvements in sexual dysfunction, it is possible that agents of R. damascena oil have an antagonistic effect on the stimulation of the postsynaptic 5-HT2 and 5-HT3 receptors30–32 and that these agents have an antago nistic effect on the corticolimbic 5-HT receptors, which are responsible for increasing sexual desire, ejaculation, and orgasm.34,35 Additionally, it is possible that the agents of R. damascena agonistically increase the release of dopamine and norepinephrine in the substantia nigra,31,32 as well as disinhibiting nitric oxide synthase.33 Further, R. damascena oil seems to have an antimicrobial effect, and has been reported to protect neurons against amyloid β toxicity, a major pathological component of Alzheimer’s disease, and to protect rats against seizures. More specifically, it is suggested that the agent glycoside quercetin is also responsible for improving neuronal activity, probably by inducing the expression of synaptic proteins synaptotagmin and post-synaptic density protein-95, at least in cultured rat cortical neurons.65 Likewise, quercetin has been shown to reduce behavioral deficiencies, restore astrocytes and microglia, and reduce serotonin metabolism in a 3-nitropropionic acid-induced rat model of Huntington’s Disease.66 Last, Merzoug et al67 reported that quercetin mitigated Adriamycin-induced anxiety- and depression-like behaviors, immune dysfunction, and brain oxidative stress in rats.

With regard to the glycoside kaempferol, evidence from animal studies has shown an antidepressant and modulating effect on brain-derived neurotrophic factor and β amyloid in the neurons and hippocampus of double TgAD mice.68

Overall, research on animal models suggest that both quercetin and kaempferol, two of the main agents of R. damascena oil, seem to have beneficial influences on symptoms of depression at the molecular level.

Moreover, we also observe that explaining the occurrence and maintenance of MDD in terms of monoamine deficiency is just one of several putative pathways by which MDD might be explained neurophysiologically and neuroendocrinologically. In this regard, more recently efforts have been made to further investigate the roles of the neuropeptide brain-derived neurotrophic factor on MDD,10,69,70 on ketamine,71 and statins.72–75 With regard to statins, by using a mouse model, Ludka et al16 observed that after acute atorvastatin treatment, the antidepressant effect seemed to be explained via the L-argininenitric oxide-cyclic guanosine mono-phosphate pathway; atorvastatin seemed to inhibit NMDA (N-methyl-d-aspartatic acid) receptors and NO-cGMP (nitric oxide-cyclic guanosine monophosphate) synthesis, leading to a down-regulation of excitatory processes. On a behavioral level, this down-regulation seems to be reflected in a reduction of symptoms of depression. However, it remains unclear to what extent the new pathways explaining MDD neurophysiologically and neuroendocrinologically may help to better understand the influence of the agents of R. damascena oil on both symptoms of depression and sexual dysfunction."

Never Heard of it. Here's the title: Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: results from a double-blind, randomized, and placebo-controlled clinical trial

Thanks for posting this! Looks like it has some possibility of working.

[Ghost]

"Our first hypothesis was that the administration of R. damascena oil would improve sexual dysfunction more than a placebo would, and this theory was fully supported. Accordingly, the present study is a contribution to the current literature because, to the best of our knowledge, for the first time the success of an agent in the treatment of an SSRI-I SD in male patients suffering from MDD was proven in a double-blind, randomized, and placebo-controlled clinical trial." I'd encourage someone to try this. I would, but have other things that I'm trying first.

[north4]

double proven bullshitbingo.... did you noticed the price of this oil ?

why nobody in any group reported: oh iam a part of double proven placebo mega crab study...

a few time ago there was a study to cure pssd with saffron. holy crab pharma is kidding us.

[pete]

what has pharma to do with rosa damascena oil? pls tell me.

and why should people, who are on ssri, hang out in some strange groups? sexual dysfunction is just a regular side effect for them.

[north4]

"a regular side effect for them" for the fda too ? try to get an offical paper from them. in germany you dont get it.

all has startet with yahoo group and wikipedia articel. and all the time that misterious cured cases from bupropion and many more, never write in a forum ?

tell me if it worked as good the other studys sayn....

[EricCartmanRJ]

It looks like it worths its weight in gold, indeed. Also, I tried looking for it all over the web (iherb, evitamins, for example) and it seems there isn't any form of preparation made for ingestion on market. It's widely used for aromatherapy.
Nevertheless, it looks promising.

[Ghost]

double proven bullshitbingo.... did you noticed the price of this oil ?

why nobody in any group reported: oh iam a part of double proven placebo mega crab study...

a few time ago there was a study to cure pssd with saffron. holy crab pharma is kidding us.

Well none of these people had PSSD, they were just on SSRIs. I don't see why pharma would try and support this article, which admits that up to 70% of SSRI users report sexual disfunction while on them.