Why has Vortioxtine (Brintellix) "helped" with ED?

[Zero]

Stuff was outdated and naive. Vortioxetine helped due to strong 5-HT1A agonism. I took 20mg of it for 3 months. My psy told me that Brintellix isn't a SSRI which is obviously a BS. This drug also desensitizes autoreceptors according to some researches, but I didn't feel that, although my dick after cessation felt rather weakened. Overall I don't recommend this drug, was close to sugar pill in my case.

There was some semi-dangerous herbal BS in this topic written by me. Ginkgo, Shilajit and Rhodiola were interesting, but nothing spectacular. Ginkgo dosing was absurdly high. Nobody told me that HED (human equivalent dose) exist. 100mg for mouse = 50mg for rat = 8mg for human.

One thing worth mentioning is Clomid and Tamoxifen. Right after ceasing Sertraline my genitals were in a really bad shape, blood test confirmed that: low T, high E2, reference prolactin though. Literally I have no dick and I mean that. Initially I took too much Clomid, had panic attack after a week, Tamoxifen was milder in that departement, althoug after month had two weeks of continous 'severe?' panic attack. Dosages from bodybuilding forums are ridiculously high in my opinion. 5mg of Tamoxifen ed, or 25mg of Clomid eod seems to be reasonable. Eternal question is Clom or Tamox? In my opinion rather Clomid, Tamoxifen is antiestrogenic which could kill libido. Overall it depends on genetics and stuff.

Tamoxifen doubled my testosterone and brought my dick partially back. I took it for a month, after next two months testosterone returned to levels before treatment, nevertheless some benefits remained. This stuff I recommend, it doesn't solve problem, but gives "favorable environment". Every single SSRI decrease testosterone production, so reason is obvious.

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[Ghost]

Last month was more like plateau, rather than going uphill, so I've changed my regime. In order of importance:

Ginkgo Biloba: 1.2g
Panax Ginseng: 3g (as a Ginkgo's "support")
Shilajit: 1.2g
Inositol: 16g

Shilajit do its job well, but it's not an answer. According to studies Ginkgo should reverse desensitisation of Ht51A and in my opinion - it does. 3 days after I've upped dose of Ginkgo to 20 pills per day I noticed so called "morning wood". Dreams appeared also.

I'll try to reach 3-4g of Ginkgo per day and going to add Biopierine and Curcumin. Hopefully my brain wouldn't melt.

Stuff I consider irrelevant now: ashwagandha, forskolin, piracetam, choline, DAA, sulbutiamine, yohimbine (nice, but it's a nasty stim).

keep us posted. Did you ever notice any memory problems on Inositol? I'm very interested in it, but that is my one concern as I am a student.

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[scot]

Wrong

[jaiho]

I found something interesting on these new classes of SSRIs.
Apparently if an SSRI has 5ht1a agonist activity, it doesn't bind to the serotonin transporter as robustly.

the mean SERT occupancy in the raphe nuclei at steady-state conditions was ≈50% at 5 mg, 65% at 10 mg, and >80% at 20 mg of vortioxetine.

http://www.sciencedirect.com/science/ar ... 5814001272

This is interesting because all the classic SSRIs bind to 90% of SERT from the lowest dosage started. This might explain why these SSRIs have less sexual side effects than the rest.