PDE5 inhibitors (PDEis) (Viagra/Cialis/Levitra)

[JayR]

Hello everyone. Like other forum users, I also do not feel the effect of alcohol. Lately I tried coffee and I noticed that it no longer trembles. But I noticed that Cialis works. When I use it I also have improvements on libido and mood. It's strange, because most people with PSSD do not benefit from it.

Cialis is long-acting, the sustained cGMP levels should restore Cognitive Function & Memory, if affected.
STUDY --> https://www.ncbi.nlm.nih.gov/pubmed/25446565
It makes sense, since it inhibits PDE-5 everywhere, there is PDE-5 in the Brain...just lesser than PDE4 and PDE8.

[Rb26dett]

It's good to see you're back, JayR!

[JayR]

It's good to see you're back, JayR!

Yes I am back. Feeling like a King, too!

[Snake]

Tried 50mg of viagra today, no effects

[Snbshocker711]

Tried 50mg of viagra today, no effects

25mg generic worked well with my ex. Do you think people who respond well to this have more of a psychological issue?

[Snake]

Tried 50mg of viagra today, no effects

25mg generic worked well with my ex. Do you think people who respond well to this have more of a psychological issue?

I really have no clue, my erections even with viagra are still shitty

[Snbshocker711]

Tried 50mg of viagra today, no effects

25mg generic worked well with my ex. Do you think people who respond well to this have more of a psychological issue?

I really have no clue, my erections even with viagra are still shitty

I can get physically stimulated and when I used it in the anticipation of sex, I got rock hard and it stayed so hard it hurt (in a good way) and can feel sensitivity. My problem is visual stimulation is non existent

[finaceatetracycline]

Yes they work, but I notice that sometimes they don't work well. I HAVE DISCOVERED HOW TO FIX THAT. I go to the gym sauna! and suddenly my Levitra works better again

[IHateProzac]

One of the major problems for me has been the diminished efficacy of PDE5i since I came off SSRI (Prozac). Over the years I have regained minor improvement but it requires manual stimulation, the erection would go away quickly, and the penis still largely remained soft. However, recently I have moved to England & for some reasons, few improvements I had on PDE5i seem to be taking nosedive. I have read that substances like Berberine & Pregnenolone can help restore the PDE5i efficacy. Any suggestions & opinions would be welcome. To say I am back in "desperation box" would be an understatement.

[mrstaircase]

For pde5i's to work properly you need adequate amounts of NO (nitric oxide). Speculation is PSSD causes decreases in NO levels.
You could give L-citrulline and L-arginine a try. Both cause increases in NO levels. I prefer L-citruline because L-arganine causes rapid tolerance amongst other things.

For the pde5 expression part:

Testosterone is a regulator of pde5 expression. So more testosterone, less expression.

Long term use of cialis (tadalafil), horny goat weed and berberine are speculated to also decrease pde5 expression. You often hear people on the internet mention that cialis seems to work better the longer it's used.