Would like to thank Ghost for inviting me to this forum.
I received PSSD, after eating 4 months of Cipralex (Escatilopram), I had the classical symtoms, loss of libido (lust), loss of sensitivity in the penis, softer erections, harder to orgasm, and not very pleasurable orgasms. I have gone through the frustration you have felt, and the worrying associated with it. So I decided to do a lot of research.. And strangely enough I found evidence in a study done on chronic users of Ayahuasca in Brazil.
It was found that they had a significantly higher amount of 5HT-receptors in their blood platelets. This was too me an indication that Ayahuasca upregulates the 5HT-receptor family of receptors, which as we all know by now - SSRis downregulate.
So I decided to try Ayahuasca at the comfort of my home here in the western world, after doing a lot of research on it. ( Now if you decide to do it, I suggest you read on " set & setting". Not did I have the most healing experience of my life, giving a deep understanding of what anxiety & depression actually is, but it also has revitalized all the areas of my dysfunctioned PSSD.
I started having spontaneous erections, I had more lust, my orgasms felt much better and I started watching porn again as I had a new interest in it. This was after 1 TIME only!
Now I started talking to a guy on another forum, it was not related to PSSD but we had an interesting pharmacological discussion on how the MAOIs in the Ayahuasca brew upregulate 5HT-receptors. It was speculated by him that it is not the hallucinogenic compound DMT that does this, but in fact the Banisteriopsis Caapi and the Syrian Rue(MAOI-inhibitors). Two ingredients which inhibit the breakdown of DMT, giving rise to the Ayahuasca experience. This is convenient, because the MAOIs are not hallucinogenic on their own ( and do not cause legality issues in most countries).
So I decided to buy Syrian Rue extract and Banisteriopsis Extract. It does not taste particularly pleasant, but you can mix it with water, and you need a tiny amount, depending on your metabolism and weight. Between 0.2-0.6 grams if its a x10 extract.
Avoid eating food that contains tyramine during the days you eat take Syrian Rue, and absolutely do NOT MIX it while taking SSRIS or other anti-depressants or other drugs. Try it once and see how you react to it, because naturally the harmala alkaloids are potent anti-depressants on their own, and you will not only see improvement in your PSSD, but also in mood.
There is a small chance that you might feel initially more depressed, because it upregulates the 5HT-receptors and in some depressed people their depression & anxiety is actually caused by too many 5HT-receptors.. It's a bit like the initial period where you feel like crap when you start on SSRis..
Anyhow, I am back to 60-70 % of only doing harmala alkaloids 2 times(!)of baseline prior to taking SSRis with my libido, genital feeling, orgasms, erections etc.. It feels great that I have discovered Ayahuasca and I will do some more Syrian Rue in the future, alone and encapsulated in my own pill-machine





