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Re: Which thread would help the PSSD community more?

Unread postPosted: Mon Apr 08, 2019 7:19 am
by Ghost
Thanks for aidong with your pharmacology knowledge!

There was another pharmacist back in 2010/11 who cured himself with inositol.

This is one of my favorite areas of interest, once I finish medical school applications this spring I would love to read over your stuff and try to put it to practice.

Re: Which thread would help the PSSD community more?

Unread postPosted: Mon Apr 08, 2019 8:06 am
by Ciprofloxacin
I'm so happy to seeing that someone who has medical knowledge is contributing to the forum. Your approach to the solving the pssd is exactly same as I wished to be.

Re: Which thread would help the PSSD community more?

Unread postPosted: Mon Apr 08, 2019 8:31 am
by TalkingAntColony
I think what would be best is for you to continue to lay out your theories so others in the community can debate/investigate them, as well as practical solutions people can try so we can get more real world data. Your efforts are much appreciated!

Re: Which thread would help the PSSD community more?

Unread postPosted: Mon Apr 08, 2019 9:07 am
by Mesolimbo
Thanks everyone for your kind words.

Ghost wrote:Thanks for aidong with your pharmacology knowledge!

There was another pharmacist back in 2010/11 who cured himself with inositol.

This is one of my favorite areas of interest, once I finish medical school applications this spring I would love to read over your stuff and try to put it to practice.

I've come to a similar conclusion regarding inositol. It's the single most hopeful agent that can actually "reverse/cure" PSSD. But I think one needs to lower serotonin simultaneously. I wrote this just yesterday:
Mesolimbo wrote:People that try to lower serotonin feel worse off because chronically elevated serotonin would downregulate many receptors responsible for glutamate modulation, and when you lower serotonin, those receptors become even less active, causing too much glutamate inhibition. GABA dysregulation is neuroinflammatory, causing glial activation and this makes you feel even worse.

Some serotonin receptors wouldn't upregulate once you lower serotonin. Serotonin receptor subtypes behave paradoxically in regards to agonism and antagonism mediated regulatory adaptation. I've addressed this in another thread.

I think a "cure" would be lowering serotonin as well as taking 18g of inositol to upregulate serotonin receptors more rapidly. It will feel like shit, though, and could cause intense dysphoria, but someone has to bite the bullet and wait it out until serotonergic receptors upregulate and the glutamate system would come online.

A "real" cure would be addressing SERT upregulation/activation + 18g inositol. Berberine comes close, but sadly it's a 5-alpha reductase inhibitor, so there's a risk of something akin to post finasteride syndrome (PFS).

But this is not the right thread to discuss this. Best of luck with your application!

Re: Which thread would help the PSSD community more?

Unread postPosted: Mon Apr 08, 2019 1:02 pm
by Frog
This is great, thanks for all of your valuable work!