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Re: Social Isolation - Poll

Unread postPosted: Fri May 03, 2019 10:54 am
by scripy3
Fact point is Social Isolation fu*** everything
-HPA
-serotonin
-dopamine
-gaba
-allo
-5-ar
-epigentics

https://www.ncbi.nlm.nih.gov/pubmed/24781734
//
Collectively, the results from the present study demonstrate for the first time that social isolation of adult mice leads to a wide range of global epigenetic changes and these effects may have profound impact on gene expression pattern and phenotype of the socially isolated animals.
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https://www.ncbi.nlm.nih.gov/pubmed/30021357
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245370/
Indeed, socially isolated mice show a 70% reduction in the rate of allopregnanolone and 5a-DHP biosynthesis compared to group-housed
And so does depression
In depressed patients, the cortical level of 5a-reductase mRNA was dramatically decreased to about 50% of the levels measured in non-psychiatric comparison subjects

This can prevent recovery!!!