Sometimes reinstating SSRI works for some of the symptoms (if not all) when many other treatment attempts fail. It can be the only thing that works for some people, actually.
How is that possible if there is gene silencing in-effect? it seems contradictory - and it's very important to investigate this further since it can hold the final key in beating PSSD for good: it begs the question, does SSRI reinstatement improve symptoms through their serotonergic action or through some other unknown action?
For people who have tried SSRI reinstatement:
- Have you tried other serotonergics for symptoms before reinstating the SSRI? (i.e. TCAs or MAOIs or any other serotonergics)
- Did you reinstate the SSRI that caused your PSSD, or another SSRI altogether?
- Did you experience SSRI withdrawal syndrome after quitting the SSRI? was it minimal or severe?