L-histidine temporary success

[lostdrive]

Hello everyone,

Sorry for my english and my long post ...I am a long time reader but have never posted until now

I am 37 years old and I have been pssd for 10 years of escitalopram.
Before escitalopram I had a very strong libido and never an erectile dysfunction.
I took this for 3 months and after I stopped (because of loss of erections) i got :
- low libido (every time I have a got sex I have to wait a month to start having a slight desire to have sex)
- soft ercetions (60% of my pre-pssd)
- soft gland
- very weak ejaculation
- loss of strength when I exercise
- Anhedonia (no rush of music or alcohol)
- penis shrinkage

my test labs are almost normal:
- testosterone (total and free) low range but standards
- estradiol high rank but in the standards
x progesterone is very low
- tsh t3 t4: ok but tsh a little high (2.95) according to a doctor
- Vitamin D deficiency
- Vitamin B9 deficiency


I have tried so many thing against pssd but nothing works and i also noticed that i was very sensitive to some supplement:

- cialis daily: very slight improvement in erection (maybe 75% of my pre-pssd)
- HCG + arimidex: nothing
- testogel: nothing
- Buspar: nothing
- low dose of naltrexone: worse
- low dose ssri: worse
- progesterone: crisis of tachicardia
- inositol: nothing
- tyrosine: nothing
- loratadine + cialis: nothing more with cialis
- Maca: nothing
- euthyral (medial thyroid): worse
- deprenyl: worse and intense tiredness
- sam-e: worse
- vitamin b9: worse
- vitamin d: systematic erectile dysfunction on that
- omega 3: systematic erectile dysfunction on that
- magnesium: systematic erectile dysfunction on that

+ others supplements but too much to list everything.


the next drugs I want to try are:
9-mbc but I can not find where to buy it
doxazosin + cialis


Recently I read about this forum about l-histidine that I tried.

It's the only thing that has worked for 10 years!
my erections have returned to 95% and maybe 98% when stack with cialis. My ejaculations came back very hard and my penis was bigger even at rest.
But it lasted a few days and histidine does not work anymore (moreover I feel that it makes me lose hair).
I saw a similar case and I tried to add:
- zinc
- copper
- cysteine
- Potasium
- vitamin b9

but it does not work anymore!

Do you have an idea about it?

[Ghost]

Speak with gbold from the hackstasis forum.

Most of the time he speaks total nonsense and spends most of his day yelling when people can't understand his broken english, but he is the one who started this theory in its modern form.

[Jaxx]

I believe buffkin here had the same experience? https://hackstasis.com/threads/my-pssd- ... ed-me.463/

Also, getting tired from selegiline is something i have never heard, quite the opposite actually! pretty weird to hear.
Gbold will say you need to get an ARL hairtest + their balancing program, just a heads up.

[lostdrive]

Speak with gbold from the hackstasis forum.

Most of the time he speaks total nonsense and spends most of his day yelling when people can't understand his broken english, but he is the one who started this theory in its modern form.

I believe buffkin here had the same experience? https://hackstasis.com/threads/my-pssd- ... ed-me.463/

Also, getting tired from selegiline is something i have never heard, quite the opposite actually! pretty weird to hear.
Gbold will say you need to get an ARL hairtest + their balancing program, just a heads up.

Hi guys,
Thank you for your answers. yes I made a post on hackstasis too. I saw the post of buffkin but he doesn't seem to have found a solution to restart the effect of histidine ... I think that as for serotonin there must be a regulation of histamine, that's why histidine stops working.

Another thing I did not mention before, I saw an anti-aging doctor. He checked my deficiencies, hormone panel, food intolerance, neuromediators.
It seems that I have a deficiency of dopamine and serotonin but I do not know if the urinary dosage is reliable.

neuro.jpg

A strange thing is that my:
SOD, Gluthation, Q10, DHEA sulfate, pregnenolone exceed max values but bioavailable testosterone is a bit low but in the lab range.

[raven100]

bump, post hadn't been approved yet

[Juvo]

The l-histidine is interesting. I did a little research and found that histidine breaks down to glutamate. Glutamate has a close relationship with 5ht and is a co-transmitter.

"Concerning the role of different subtypes of 5-HT receptors, it has been shown that GABA release from CA1 interneurons is inhibited by 5-HT1A receptors [90, 163] and enhanced by 5-HT2 [166] and 5-HT3 receptors [90, 121, 157, 179]"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430669/

Not really sure what this means but I'd be curious to see if histidine works in others as well. Has anyone had any improvement or windows from benzodiazapines?

[Juvo]

I think there might be something here with GABA. Besides the l-histidine, Alcohol mimics gaba effect and one of my three windows was after withdrawing from large alcohol consumption.

[naiverat]

@Ghost, I was wondering your opinion on Gbold's info on the Hackstasis forum. It seems like everyone takes his ideas as the word of god over there. He supposedly cured his cancer, reversed his age by 20 years, etc. It all seems a bit far-fetched. No doubt a healthy lifestyle has an impact, but 40 -day fasts and weekly liver flushes, which look a bit pseudo-sciencey to me.

It seems some people have had results following his guides, so I was considering it. I just don't want to needlessly invest in a ton more supplements that are going to be a waste of money.

[JayR]

Histamine reduces GABA by histamine H2-receptors in the hypothalamus, thus triggering Glutamate, thus increases nitric oxide, thus facilitating sexuality.
--> https://www.ncbi.nlm.nih.gov/m/pubmed/6455100/
In humans, histamine via H2-Receptors stimulates Erection.
--> https://www.ncbi.nlm.nih.gov/pubmed/7850330


Br J Urol. 1995 Feb;75(2):220-4.
The role of histamine in human penile erection.
Cará AM1, Lopes-Martins RA, Antunes E, Nahoum CR, De Nucci G.
Author information
Abstract
OBJECTIVE:
To investigate the relaxant action of histamine on human corpus cavernosum in vitro and the erectile response caused by the intracavernous injection of histamine in patients with psychogenic impotence.

PATIENTS AND METHODS:
Human corpus cavernosum (HCC) tissue was cut into strips of approximately 2 cm and suspended in a cascade bioassay. The strips were then superfused with oxygenated and warmed Krebs solution and precontracted with noradrenaline (3 microM). Glyceryl trinitrate, acetylcholine and histamine were injected as a single bolus in the absence or in the presence of mepyramine and cimetidine. For the in vivo studies, histamine (30-60 micrograms) was injected intracavernously as a single bolus into the right corpus cavernosum 1 cm from the balamo-preputial sulcus. Similar protocols were carried out for papaverine (50 mg). The erectile response was divided into four grades: no response, tumescence, partial and full erection.

RESULTS:
In vitro studies demonstrated that histamine (3-100 micrograms) caused dose-dependent relaxation of the HCC strips which was significantly inhibited by cimetidine (5-10 microM). The histamine H1 receptor antagonist mepyramine (1 microM) potentiated histamine-induced relaxation. The co-infusion of both mepyramine and cimetidine did not abolish histamine-induced relaxation. When injected intracavernously in humans, histamine (30 micrograms) caused full erection in 13% of the patients, whereas 87% had partial erection or tumescence. A higher dose of histamine (60 micrograms) caused full erection in 26% of the patients and 74% had partial erection or tumescence. Papaverine induced full erection in the majority of patients (66%). In contrast to papaverine, the duration of erection induced by histamine was markedly shorter (mean 200 and 6.5 min, respectively). The penile erections induced by papaverine were associated with complications such as pain, haematoma and priapism. Histamine did not induce any complications. Treatment of eight male patients with psychogenic impotence with the histamine H1 receptor antagonist astemizol (10 mg orally once daily for 1 week) did not affect histamine-induced erectile responses.

CONCLUSION:
These results indicate that histamine may play a role in human penile erection. The erection-promoting action of histamine is probably due to H2 receptor activation, although another histamine receptor, possibly H3, also seems to be involved. This study suggests that histamine could be a valuable tool in the diagnosis of erectile dysfunction.

[Ghost]

@Ghost, I was wondering your opinion on Gbold's info on the Hackstasis forum. It seems like everyone takes his ideas as the word of god over there. He supposedly cured his cancer, reversed his age by 20 years, etc. It all seems a bit far-fetched. No doubt a healthy lifestyle has an impact, but 40 -day fasts and weekly liver flushes, which look a bit pseudo-sciencey to me.

It seems some people have had results following his guides, so I was considering it. I just don't want to needlessly invest in a ton more supplements that are going to be a waste of money.

Gbold is smart, but he contradicts himself, is confusing, and is condescending to anyone who doesn't understand his broken english. It's quite clear to me that he doesn't realize that the body is more complex than: a leads to b leads to c leads to d - boom! CURE. It's clearly never as simple as that.

I don't think it's a waste of money per se, but he has rattled off about 15 "cures", and I haven't seen much PSSD improvement AT ALL.