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Varicocele-guy introduction and a possible breakthrough - Normal dose naltrexone

Unread postPosted: Sat Feb 10, 2018 1:17 am
by varicocele-guy
Hi everybody.

Straight to the point: my case is complicated and this will be a very long post. I will highlight the most important parts of it. I'm a
28 year old male. You can skip this post to the end if you want to read about the most interesting thing about naltrexone.

December 2015: I was prescribed 40 mg of paxil daily, sulpiryd (when needed), and some anti-anxiety drugs like xanax and hydroxyzine
for my porn addiction (it was severe - i could stay up all night watching porn without sleep, I had no libido towards real women, no
morning wood etc.). Porn addicts also report a phenomenon called "flatline" which occurs for some time after abstaining from porn -
it's a time when you have no libido, no morning wood etc.


February 2016: I got a new well paid job. Soon the anxiety stopped, I stopped taking xanax and hydroxizine because my sleep improved.
The addiction losed its grip on my life and I could focus on daily life.

March 2016: I was diagnosed with short frenulum in my penis, so I took a surgery to correct it. I was also diagnosed with third grade
varicocelles.

May 2016: I had an addiction relapse. I also took sulpiryd after the relapse. I told myself that I will abstain from watching porn and
when I'll feel that I can do it, I'll go for a paid sex (because back then I was still a virgin).

July 2016: I had first sex in my life - it was a great experience. I reached orgasm twice - the first one was a bit premature and on
the second one I couldn't get hard enough erection to do it classically but I got an orgasm in other way. I haven't used viagra or any
other sex-enhancing meds. Let's call this person which I had sex with A.

August 2016 - December 2016: I focused on daily life and didn't think too much about sexual stuff. No libido, no morning woods. Still
on 40 mg paxil. Met a woman on tinder and we went to her friend's wedding, but some time after the wedding she rejected me.

November 2016 - I've met a woman in which i think that I fell in love but she rejected me in the beginning of January 2017. In the
middle of December 2016 I also had porn relapse which went on to February 2017.

January 2017 - I got a new job (better paid than the last one, and also stress-free). I decided to try paid sex once again with A. . I
took some viagra and first orgasm was very quick (premature ejaculation). After the first one my penis was still hard but it was very
hard for me to get an orgasm, but I managed to achieve it after 15 minutes.

March 2017 - Paid sex once again, this time with different person. It was an enjoyable experience. From what I remember I also took
viagra.

June 2017/July 2017 - Morning wood returned. I also felt a huge increase in libido. I remember that when I went on a lunch with my
colleagues from work, one girl from the table next to us caught my attention. I was so attracted to her that I went to the bar and
asked for a piece of paper and a pen. I've written my phone number on it and discretely passed it to her. She didn't call.

July 2017 - I had a very big appetite for sex so I decided to take advantage of it. I had sex with A. and there was no need for me to
use viagra. Everything was ok. Soon after that I relapsed to porn, morning wood and libido disappeared. Nevertheless I decided to go
for paid sex with another person. I had to take some viagra and I had the same issues as I had with previous attempt with A. (January
2017) - premature ejaculation and after it I had difficulties to get to second orgasm.

August 2017 - things are starting to get complicated from now on. I googled up on the internet that the varicocelles I mentioned
earlier impair testosterone production (the fact that the doctors haven't told me). This would also explain my mediocre bed performance
and constant lack of libido. I got my blood tests and indeed I had high estrogen (close to upper range - 33/39) and relatively low
testosterone (386) I was scheduled a surgery on September 2017. I also went to my psychiatrist and she decided that I should quit
paxil. She also prescribed me naltrexone so I would manage porn cravings when they arise. So the plan was as follows - slowly taper off
the paxil, introduce prozac along it, to ease paxil withdrawal. Then within a month I should be only on prozac + naltrexone and after
that taper off the prozac.

September 2017 - Two days before the varicocele surgery I quit everything - prozac and naltrexone. I took the surgery on 11th of
September. Two days after the surgery I got back home. 6 days after the surgery and 9 days after quitting meds I noticed the return of
morning erections. I started to feel an increase of energy. I started to sleep very well. I had an urge to masturbate so I masturbated
once per 3-4 days and it was a pleasant surprise for me that after masturbating without porn, my morning erections were still there. I
was also experiencing spontaneous erections throughout the day. I started to feel that I'm cured from my porn addiction and that it was
the beginning of my new, better life. My plan was to go for paid sex from time to time, but the long-term goal was to meet ladies on
tinder. On 30th of september I went for a paid sex (with different person, lets call her B.) and this one was the best in my life. 2
days later I took another hormone blood test (out of curiosity) to see if I was right about the hormones and it turned out that my
testosterone increased from 386 to 560 (estrogen stayed on the same level - 33). I also celebrated my birthday party and got drunk.
During this period of well-being and high libido i was experiencing occasional zaps and paresthesias from SSRI withdrawal
but aside from those very mild symptoms (they were so mild that I didn't even told about them to anyone) I haven't experienced any other side-effects.

October 2017 - I catched a severe tonsilitis on 11th of october. I was prescribed antibiotics. On the second day of my disease the
throat pain was so severe that I took one dose of tramadol (which was in my parents house). My energy, libido and morning erections
started to gradually disappear. I took another hormone test after I cured tonsilitis but I was still on antibiotics - my T levels went
down. So this was the simplest explanation why I was feeling worse. I also relapsed to porn. I went to an andrologist and he prescribed
me clomid to boost my T levels. Morning wood and libido was now gone.

October/November 2017 - I took clomid for 2 weeks, I got a blood test on the second week and my testosterone and estrogen levels
skyrocketed above the upper reference range so I quit clomid. Still no libido, no morning woods. I relapsed to porn once more and
things started to worry me - even with porn, the quality of erection was bad. It was hard to maintain it. I've read about PSSD and I
started to worry much more, but I told myself that before assuming the worst, lets try to rule out other causes. After withdrawing from
clomid i took another hormone blood test and every hormone leves was as good as it was in september when I was feeling so well. At this
time I've posted on the peaktestosterone forum:

http://www.peaktestosterone.com/forum/i ... #msg123890

December 2017 - I decided to go to B for paid sex once more. I took much more viagra than I used to take (even when I was on paxil) and
it was hard for me to maintain an erection. First orgasm - premature ejaculation - and what was different - that I couldn't maintain an
erection after the first orgasm (in contrast to what happened when I took viagra on while I was on SSRI). I had also a porn relapse
(but without masturbating) 2 weeks after i visited B. 2 days after the porn relapse I visited B and this time it was a complete
failure. First orgasm after 10-20 seconds of intercourse. After that I couldn't get my penis up. Some days later I took another
testosterone blood test - 640 testosterone.

End of december 2017 - I've read on peaktestosterone.com about naltrexone, that it helps with "idiopathic erectile dysfunction". There
was also a link to medical articles about naltrexone and ED stating that naltrexone in normal doses (25 - 50 mg, not LDN) restores
morning erections. Since I had some naltrexone left I decided to give it a try. To my surprise on the second day of taking naltrexone
(25 mg in the morning an hour before breakfast)I HAD A FIRST MORNING ERECTION IN 2 AND A HALF MONTHS. So I decided to continue taking
naltrexone. With it I was able to get a rock-solid erection with some fantasizing. I also had no urges to watch porn.

January 2017 - with my morning and nocturnal erections restored (no changes in libido and spontaneous erections). I decided to go to
another psychiatrist. I told him about everything and he decided that I should continue on taking naltrexon and that in february i
should start tapering it off. The erections were so good that I was very confident that if I had an intercourse, everything would be
fine. Still the lack of libido bothered me so I took a prolactin test just before quitting naltrexone - the prolactin level was high
(in contrast to my relatively low prolactin levels while I wasn't on naltrexone and had ED problems), but still in range.

End of january 2017 - I was a bit impatient with my libido not returning so I quit naltrexone cold-turkey to see what would happen. The
improvements in erections lasted for 5 days. Now I'm back in square one, where I was before taking naltrexone. I can't maintain an
erection during masturbation. I can achieve an erection with perversive fantasies but I can't maintain it. I've read so much about
pssd, possible cures that I started to freak out and experience severe fear since last friday that it started to interfere with my job
and daily life. I went to the psychiatrist and even though he seems to somewhat acknowledge the existence of PSSD, he said that it's in
my head and that those issues are from lack of partner. He prescribed me tianeptine (coaxil). He told me it's an anti-SSRI and that it
enhances serotonin reuptake and that it reverses pssd. So right now i'm taking tianeptine for 2 days. My anxiety and fear is much less
now. I also try to reconcile with the fact that this indeed may be pssd and that I might not regain my sexual functions soon or maybe
never. Because I have friends which support me and parents which love me and I don't want to freak out because of my loss of sexual
functions.

So my plan is as follows:
- reconcile with the fact that this may be pssd, and focus on my daily life, getting a better job and buying an apartment
- take the tianeptine as the psychiatrist told me to.
- stop reading about pssd for some time, because I don't want to lose my sanity.
- check back in this thread in about 6 or 8 weeks.
- after I quit tianeptine in about 2 or 3 months, let the brain rest for a while and experiment firstly with inositol and if that
doesn't help - low-dose ssri (2,5 mg of paxil 2-3 times a week) - one guy claims that he cured his PSSD with low doses of paxil.

And most importantly I would like to ask:
Has anyone here tried normal dose (25 - 50mg) naltrexone for PSSD? It restored my erections in 2 days while i was taking it.


I also found a med article from 2008 year titled "Alleviation of both binge eating and sexual dysfunction with naltrexone"
the article is about a case study of a woman, who was addicted to heroin but managed to overcome the addiction. Later she was
treated with SSRIs. After she was treated with SSRIs she had episodes of binge eating. She was prescribed naltrexone (50 - 100 mg
daily) for binge eating and surprisingly she reported a return of sexual fantasies. She stopped taking naltrexone because her
perscription ended and the fantasies went away. She got a new perscription and was taking naltrexone for the next three months - the
fantasies returned and were present during the treatment.
The article states that "it's too early to propose naltrexone for post ssri
induced sexual dysfunction and more studies need to be done"
So I see the similarity here with my case when I also took naltrexone.

Also to be clear - I had problems with libido and morning erections when I was abusing porn, before I took SSRI.

Re: Varicocele-guy introduction and a possible breakthrough - Normal dose naltrexone

Unread postPosted: Sat Feb 10, 2018 12:43 pm
by marsupial
Its interesting. Isnt that possible that naltrexone is interfering with your addiction thus allowing you to regain your pre addictive skills? I know you claimed you would keep of reading about PSSD but if you have something interesting for us to tell, please share.
This article seems promising for naltrexone https://www.ncbi.nlm.nih.gov/pubmed/2543996

Re: Varicocele-guy introduction and a possible breakthrough - Normal dose naltrexone

Unread postPosted: Sat Feb 10, 2018 1:58 pm
by north4

Re: Varicocele-guy introduction and a possible breakthrough - Normal dose naltrexone

Unread postPosted: Sat Feb 10, 2018 3:24 pm
by marsupial
i dont want to log in. what is it about?

Re: Varicocele-guy introduction and a possible breakthrough - Normal dose naltrexone

Unread postPosted: Sun Feb 11, 2018 8:37 am
by varicocele-guy
marsupial wrote:Its interesting. Isnt that possible that naltrexone is interfering with your addiction thus allowing you to regain your pre addictive skills? I know you claimed you would keep of reading about PSSD but if you have something interesting for us to tell, please share.
This article seems promising for naltrexone https://www.ncbi.nlm.nih.gov/pubmed/2543996


This is the article which I have found initially and after reading it decided to give naltrexone a try. To clarify - naltrexone didn't have this effect on me when I took him while I was tapering off paxil.

Re: Varicocele-guy introduction and a possible breakthrough - Normal dose naltrexone

Unread postPosted: Mon Feb 12, 2018 3:50 pm
by Twentyoneguns
I suffered badly from CFS for 5 years and I showed little sign of recovering. A fellow sufferer I know had great success using LDN (low dose Naltrexone), her partial recovery was quite remarkable. I decided to try LDN myself and started my dose at 0.5mg, as suggested by the clinic that supplied it, a few minutes after taking my first dose I had a similar reaction to my immediate adverse reaction to Sertraline....dizzy, and feeling weak and exhausted, terrible headache and generally not feeling with it.

Thank goodness I returned to normal within 24 hours

Needless to say I didnt continue with LDN....I cant imagine what would have happened if Id taken Naltrexone at the full dose....some 50 to 100 times my low dose.

Treat this stuff with care!

21g

Re: Varicocele-guy introduction and a possible breakthrough - Normal dose naltrexone

Unread postPosted: Tue Feb 13, 2018 11:44 am
by marsupial
Twentyoneguns wrote:I suffered badly from CFS for 5 years and I showed little sign of recovering. A fellow sufferer I know had great success using LDN (low dose Naltrexone), her partial recovery was quite remarkable. I decided to try LDN myself and started my dose at 0.5mg, as suggested by the clinic that supplied it, a few minutes after taking my first dose I had a similar reaction to my immediate adverse reaction to Sertraline....dizzy, and feeling weak and exhausted, terrible headache and generally not feeling with it.

Thank goodness I returned to normal within 24 hours

Needless to say I didnt continue with LDN....I cant imagine what would have happened if Id taken Naltrexone at the full dose....some 50 to 100 times my low dose.

Treat this stuff with care!

21g

I will try to get it and try it. and I will keep your warnig in mind. What baffles me is that you took 0.5 mg. How you made it when these tablets are susually 50 mg? Isnt there some missconception about the dosage from different companies/brands?

Re: Varicocele-guy introduction and a possible breakthrough - Normal dose naltrexone

Unread postPosted: Tue Feb 13, 2018 1:12 pm
by Twentyoneguns
Hi Marsupial

I got the LDN from Clinic 158 in Glasgow. They provide the LDN as a kind of syrup liquid at a strength of 1mg/1ml...starting dose was 0.5ml, increasing by 0.5ml every two weeks until 4.5ml.

I just dug the bottle out of the back of the fridge, it is dated 19 December 2016, just after my PSSD started...though I dont remember taking it for PSSD, just the CFS.

Googling Clinic 158 now only takes me to a logo, but info about the clinic can still be found on other sites, maybe some other company provides the same service.

The actual LDN came from Homedelivery Pharmacy 35 Rutherglen Arcade Glasgow G73 2LS Tel: 0141 404 6545, although the prescription needed to come from Clinic 158 first.

21g

Re: Varicocele-guy introduction and a possible breakthrough - Normal dose naltrexone

Unread postPosted: Mon Feb 19, 2018 12:10 am
by varicocele-guy
north4 wrote:https://groups.yahoo.com/neo/groups/SSRIsex/search/messages?query=naltrexone


Could you tell us what are the yahoo group user's experience with naltrexone?
I can't access this site because I'm still not a member - I have requested access to this group in the last week but my request hasn't been accepted yet.

Re: Varicocele-guy introduction and a possible breakthrough - Normal dose naltrexone

Unread postPosted: Tue Jul 10, 2018 5:24 am
by varicocele-guy
I've found something which may explain why naltrexone temporarily fixed my erecions but not libido:

http://pharmrev.aspetjournals.org/conte ... ll#title62

Several central transmitters involved in the erectile control have been identified. Dopamine, acetylcholine, nitric oxide (NO), and peptides, such as oxytocin and adrenocorticotropic/α-melanocyte-stimulating hormone, seem to have a facilitatory role,


The erection following paraventricular D2receptor stimulation apparently involves oxytocinergic neurotransmission (Carter, 1992). Dopaminergic neurons impinge on oxytocinergic cell bodies in the PVN (Buijs, 1978; Lindvall et al., 1984), and apomorphine-induced penile erection is prevented dose dependently by oxytocin receptor antagonists (Argiolas et al., 1987b;Melis et al., 1989) or by electrolytic lesions of the PVN that deplete central oxytocin content (Lang et al., 1983; Hawthorn et al., 1985;Argiolas et al., 1987a). Conversely, injection of oxytocin into the PVN induced erections that were not attenuated by dopamine receptor blockade, suggesting that dopaminergic neurons activate oxytocinergic neurons in the PVN and that released oxytocin then accounts for the erectile response (see Section II.1.6.).


Why I'm emphasizing here on oxytocin? That's why:

https://www.ncbi.nlm.nih.gov/pubmed/2864649

Inhibitory influences of opioids on the secretion of both oxytocin and vasopressin have been described.


Naloxone, relatively mu-selective, enhanced oxytocin secretion by up to 90% with a half-maximal effect at approximately 10(-6) M. MR2266, a relatively kappa-selective antagonist also enhanced oxytocin secretion but displayed agonist-like activity at high concentrations.


https://link.springer.com/article/10.1007/BF00237032

Thus, when Clarke et al. (1979) stimulated the neural stalk following intravenous injection of the opioid antagonist naloxone, they observed that the evoked oxytocin release was potentiated. In the present study we confirm this result and show that oxytocin release evoked by stimulation of the supraoptic nucleus is similarly potentiated by naloxone. This finding is consistent with the hypothesis that the opioid responsible for inhibition of oxytocin release coexists with either oxytocin or vasopressin.


So, dopamine system acts on oxytocynergic system which results in erections. There isn't enough dopamine, so naltrexone increased the release of oxytocin therefore repairing erectile function without facilitating libido, because still there wasn't enough dopamine in the first place to act on oxytocynergic system and to provide libido. It seems to me that PSSD is some kind of dopaminergic system dysfunction.