lordofpssd intro/symptomatic relief trial

[lordofpssd]

Update:

Ive currently titrated up to 10mg memantine and am planning on going up to the full 20mg dosage before introducing anything else. I took it slow starting at 2.5 the first week then moving up to 5 for a week and now 10mg This week. Because of taking it slow side effects has been minimal in severity and i have felt slight sporadic reliefs in some symptoms (mainly anhedonia) during this time where i have noticed increased hunger and pleasure to food as well as slight pleasure to music, socializing and ability to laugh. This has only been in small sporadic spurts tho and not in any big way. It seems that these effects are most notable during titration and once Ive stabalized on one dosage it goes away. It feels like What is happening is that my altered homeostasis (pssd) gets temporarily «nudged» because of the change introduced to the brain (in This case memantine titration) But it fights back and quickly takes control again. This seems to be the thing with most substances that i have ever felt a slight response to; it works a bit in the beginning But quickly fades. Sometimes i only get brought out of the fog for a few hours before i Get stuck back in pssd limbo. Its a neverending battle.

Anyway i also want to mention that i ordered a few tablets of flibanserin to try out once i have stabalized on memantine.
After stabalizing on 20mg memantine i plan on introduce the following meds;
- Baclofen 12.5/25mg
- Rasagiline (0.25-0.50?)
I would also like to try cyproheptadine and rivastigmine after reading mesolimbos anecdotes.

Current remigen:
- Memantine 10mg
- LDN 3mg
- Seroquel 25mg
- Pregabalin 150mg prn

I have decided to try and log my progress symptomswise from now on to give a more clear picture of my progress and which areas needs more improvements.

These are the specific symptoms i want to adress:

Cognitive dysfunction:
* Depersonalization and derealization
* Brain fog/mental clearity
* Focus and attention
* Memory
* Verbal fluency and Word recall (also including the ability to speak properly and react naturally to conversations without blank mind)
* Loss of creativity

Current function: 20%

Anhedonia:
* Anticipatory: Motivation and drive to do activities that is supposed to bring pleasure
* Consummatory: Pleasure from activities such as socializing, gaming, tv, music, food, excercise
*Responsiveness to pleasurable substances like alcohol and drugs

Current function: 5%

Emotional range and expression:
Emotional blunting:
* Ability to feel emotions
* Empathy
Blunted/flat affect:
* Inability to cry and laugh
* Inability to connect with others
* Natural reactions to the environment without having to fake it

Current function: 0%

Sexual dysfunction:
* Libido
* Physical and mental attraction
* Erectile dysfunction
* Anorgasmia
* Genital anesthesia
* Premature ejaculation

Current function: 10%

General physical symptoms:
* Chronic fatigue
* Muscle weakness
* Lack of sensations (including diminished taste, smell, skin sensitivity)
* Various muscle stiffness and pain
* GI issues (IBS)

Current function: 25%

I will update this post later to give a percentage of Where i feel i am at with each symptom to track progress.
Edit: updated %.

[Jaxx]

Excited to read your plan, fingers crossed!

[lordofpssd]

Excited to read your plan, fingers crossed!

Thank you, much appreciated!

[Every_Thing_]

Are you improving?

[lordofpssd]

Are you improving?

Too early to tell, have to wait and see after i have stabalized on memantine and ready to introduce the new meds.

[Mesolimbo]

Sorry for the very late reply. I'm having certain trouble in life and am trying to offset it.

Your regimen looks good. Personally, my regimen doesn't work without a cholinergic. I understand that many people cannot tolerate AChEI side effects, so maybe a weaker cholinergic agent can be of benefit if you react to drugs similar to me.

Homeostasis is a bitch. I believe there's a significant sex hormone resistance problem, affecting AR/ER receptors, and causing this. There is an obvious loss of central excitatory tone, with many of us not responding to certain drugs and having loss of cravings. Neuroplasticity is down the drain.

[Jaxx]

Your regimen looks good. Personally, my regimen doesn't work without a cholinergic. I understand that many people cannot tolerate AChEI side effects, so maybe a weaker cholinergic agent can be of benefit if you react to drugs similar to me.

would huperzine A be an option to try this theory?

Anyway i also want to mention that i ordered a few tablets of flibanserin to try out once i have stabalized on memantine.

I would be very interested to hear your Flibanserin source if it comes out legit, also see viewtopic.php?f=50&t=2915

[lordofpssd]

Sorry for the very late reply. I'm having certain trouble in life and am trying to offset it.

Your regimen looks good. Personally, my regimen doesn't work without a cholinergic. I understand that many people cannot tolerate AChEI side effects, so maybe a weaker cholinergic agent can be of benefit if you react to drugs similar to me.

Homeostasis is a bitch. I believe there's a significant sex hormone resistance problem, affecting AR/ER receptors, and causing this. There is an obvious loss of central excitatory tone, with many of us not responding to certain drugs and having loss of cravings. Neuroplasticity is down the drain.

No problem man thats fully understandable.

Sounds good. I was wondering what u’d think about me maybe trying out rivastigmine with this regimen? Im really looking for something to help my cognitive impairment and brain fog, Im really struggling at work because of this.
Would maybe rivastigmine + rasagiline help in this department?

Also regarding emotional blunting and flat affect; what do u think about adding cyproheptadine for this purpose? I do remember you cautioned me against this earlier due to upregulating of pre synaptic 5ht1a so in that case, is there something else i could take instead on a consistent basis to improve these symptoms (taking away flibanserin and baclofen)?

I have also contemplated trying out Agomelatine for Its 5ht2c antagonism to see if it would help with improving my response to drugs amongst other things. Also, could abilify + agomelatine potentially be a good combo for pssd treatment (mainly sexual function)? I responded fairly well to abilify in the past when it came to libido and sensation but it made me too restless to continue taking it. It would be far cheaper for me using this than ordering flibanserin where one tablet costs 4 dollars (and thats counting that it actually successfully goes thru costums and reaches me).

[lordofpssd]

Your regimen looks good. Personally, my regimen doesn't work without a cholinergic. I understand that many people cannot tolerate AChEI side effects, so maybe a weaker cholinergic agent can be of benefit if you react to drugs similar to me.

would huperzine A be an option to try this theory?

Anyway i also want to mention that i ordered a few tablets of flibanserin to try out once i have stabalized on memantine.

I would be very interested to hear your Flibanserin source if it comes out legit, also see viewtopic.php?f=50&t=2915

Yeah ill give u a heads up if it manages to pass thru costums.

[Mesolimbo]

would huperzine A be an option to try this theory?

Huperzine A should be fine, yes.

Sounds good. I was wondering what u’d think about me maybe trying out rivastigmine with this regimen? Im really looking for something to help my cognitive impairment and brain fog, Im really struggling at work because of this.
Would maybe rivastigmine + rasagiline help in this department?

I tried both Donepezil and Rivastigmine, the latter works good enough. I don't have any cognitive symptoms on these. But be careful, many people start on a normal dose and cannot tolerate the side effects, which can be excessive. I only need 1/4 of a pill on Donepezil (1.25 mg) or 1.5 mg of Rivastigmine. People make the mistake of taking doses suitable for Alzheimer's and end up hating the drug.

Also regarding emotional blunting and flat affect; what do u think about adding cyproheptadine for this purpose? I do remember you cautioned me against this earlier due to upregulating of pre synaptic 5ht1a so in that case, is there something else i could take instead on a consistent basis to improve these symptoms (taking away flibanserin and baclofen)?

I haven't found anything that improves blunted affect except for those. Blunted affect is a very treatment resistant symptom. Some people respond to glutamatergics, or phasic dopamine releasers (psychostimulants) to some degree. Cyproheptadine doesn't work.

I have also contemplated trying out Agomelatine for Its 5ht2c antagonism to see if it would help with improving my response to drugs amongst other things. Also, could abilify + agomelatine potentially be a good combo for pssd treatment (mainly sexual function)? I responded fairly well to abilify in the past when it came to libido and sensation but it made me too restless to continue taking it. It would be far cheaper for me using this than ordering flibanserin where one tablet costs 4 dollars (and thats counting that it actually successfully goes thru costums and reaches me).

Aripiprazole made you restless probably through antagonising dopamine receptors in the negrostriatal pathway. It's a dopamine partial agonist with low intrinsic activity, making it more of an antagonist than an agonist. Perhaps you'll benefit more from another partial agonist called Piribedil, it has more intrinsic activity than Aripiprazole, being more an agonist and less an antagonist. That is, if you are not afraid of the risk of DAWS (which is a very rare condition that requires high dose of a dopamine agonist for a long period of time, you can read my article on it). I like Piribedil because it's also an alpha-2 antagonist, but still, there is a risk of DAWS to consider.