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"Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction" 2012

Unread postPosted: Sat Sep 08, 2018 11:34 pm
by anacleta
Psychiatry Research 2012 Aug 30; 199(1): 74–76.

Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction


Jeffrey R. Bishop,1,* Sharon S. Chae,1 Shitalben Patel,1 Jessica Moline,2 and Vicki L. Ellingrod3,4
1University of Illinois at Chicago College of Pharmacy, Department of Pharmacy Practice, Chicago, IL
2Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
3University of Michigan College of Pharmacy, Department of Clinical and Administrative Sciences, Ann Arbor, MI
4University of Michigan, School of Medicine, Department of Psychiatry, Ann Arbor, MI
*Author for correspondence: Tel.: 312-413-3495, Fax: 312-996-0379, ude.ciu@pohsibj

https://doi.org/10.1016/j.psychres.2012.03.048

Abstract

We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. One polymorphism in GRIA1 (rs1994862) was associated with arousal dysfunction, providing further evidence for the role of GRIA1 in mechanisms underlying SSRI-associated sexual side effects.

https://www.sciencedirect.com/science/article/pii/S0165178112001576
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458139/

Re: "Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction" 2012

Unread postPosted: Thu Sep 27, 2018 7:36 pm
by TalkingAntColony
I checked my DNA but I dont have that SNP sequenced. I wonder if anyone who has a recent 23andMe sample could see that SNP, as they sometimes add new ones and my sample is older.

Ghost, you may want to check out these glutamate receptor genes in your study.

Re: "Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction" 2012

Unread postPosted: Fri Sep 28, 2018 1:06 am
by DrugsAreBad
rs1994862 isn't in the dataset that we have access to, unfortunately. At least not in the first 16 files that I've got.

Re: "Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction" 2012

Unread postPosted: Tue Jan 08, 2019 1:51 pm
by JayR
Mine is normal = no increased/decreased risk for SSRI-induced Sexual Dysfunction.