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Alpha:Beta activity in PSSD.

Unread postPosted: Mon Jan 07, 2019 10:55 am
by JayR
Most cases of Erectile Dysfunction are resultant from an imbalance between Nitric Oxide and Adrenaline. However, the Adrenaline level, receptors, receptor functionality and such are much more important in endothelial function in general. Epinephrine & Norepinephrine (NorAdrenaline) both bind to alpha & beta-receptors, but Epinephrine has a higher affinity for beta-receptors - beta-3's of which cause Erection in Humans. This suggests its possible that in those with E.D predominant PSSD - that is, in the arousal aspect - that Norepinephrine is not converting into Epinephrine as much - or there are too many alpha-1-receptors - which would be consistent with the Research (https://www.ncbi.nlm.nih.gov/pubmed/2870173) that SSRI's increase alpha-1-receptor expression - and alpha-1 receptors are the ULTIMATE erection killing receptor (https://www.ncbi.nlm.nih.gov/pubmed/10845765)

STUDY --> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC154379/

SSRI's also are KNOWN to upregulate the "bad" Beta-receptor; the beta-1-adrenergic Receptor - which is a primary target for antihypertensive drugs and can cause pivotal changes to the Heart Rate (HR) - which may *negatively* impact Vascular/Endothelial/Cardiovascular Function.

STUDY --> https://www.ncbi.nlm.nih.gov/pubmed/7871100

Another supporting study, although perhaps indirect - is that SSRI's affect gastrointestinal neuronal Physiology including the alpha-1-Receptors.

STUDY --> https://www.ncbi.nlm.nih.gov/pubmed/15670267

On the other hand, SSRI's have some anti-Norepinephrine properties via both PRE and POST synaptic mechanisms!

STUDY --> https://www.ncbi.nlm.nih.gov/pubmed/28216049
*SOME* People might be a "High Norepinephrine, High Vasoconstriction State"...others with PSSD may be adrenergically-deficient - thus are lacking the normal orgasmic capacity to deficiency of muscular Contractions.

Here is a FULL paper with details on Alpha-1-Receptors, Depression and the antidepressant response!
--> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355451/

In a forum topic on 'AllThingsMale' - there was a THREAD called "Ultimate Adrenergic Control of Erections".

THREAD --> http://www.allthingsmale.com/community/ ... ons.19251/

This thread proposed various methods of BOTH treating E.D and PREVENTING it.
While it is true that Dopamine agonists can reduce sympathetic tone...they also have effects that desensitize ADRENO-RECEPTORS - leading to reduced Noradrenaline but increased firing of Locus Coroleus neurons [https://www.ncbi.nlm.nih.gov/pubmed/18435418].
The more likely solution for this dysfunction, predominantly erectile dysfunction DURING and AFTER SSRI's treatment is ELIMINATING the contractile influences almost entirely.
So Doxazosin (4mg) + Yohimbine (7.5mg) + Cialis (20mg) would be a good combo for most people.
I find this combination REVERSES sexual dysfunction from pretty much ANY substance.

While some have prior mentioned DEXTROAMPHETAMINE for PSSD - the problem is ALL amphetamines ALSO raise Serotonin levels...which can worsen PSSD.
In my experience Amphetamines have deleterious effects on sexual function UNLESS paired with METERGOLINE; a serotonin antagonist - at 12 MG/day....
WITH metergoline, the response to dextroamphetamine is opposite - WHOLLY enhancing to Manic-proportions of sexual drive.

Daniel Nicholas Gregory of Area-1255 LTD: http://www.area1255.blogspot.com
Co-Written by Jason Malek Russo ("JayZin De'Russo").

In cases of DBH-deficiency, I suggest reading my articles if you Suspect Low Norepinephrine/Noradrenaline levels.
--> Symptoms of Low Norepinephrine / Low NorAdrenaline (Signs of Low NorAdrenaline Levels)
https://area1255.blogspot.com/2016/03/s ... e-low.html

--> How to Increase Dopamine Beta-Hydroxylase 2019 (How to Increase DBH 2019) Increase Norepinephrine Conversion 2019
https://area1255.blogspot.com/2019/01/h ... eta_8.html

An interesting test to this theory would be something like MODAFANIL - which activates LC-Noradrenergic Neurons...to see if it affects the Course or Symptomology of PSSD.
MODAFANIL STUDY --> https://www.ncbi.nlm.nih.gov/m/pubmed/15983798/

Re: Alpha:Beta activity in PSSD.

Unread postPosted: Mon Jan 07, 2019 11:29 am
by hgwxx7
This is a wonderful approach. This topic should read by Ghost asap.

Couple of months ago I insisted that the NO is the key to understand the PSSD. Not so many people were agree with me. but this time we have bigger proofs to believe it.

Re: Alpha:Beta activity in PSSD.

Unread postPosted: Mon Jan 07, 2019 2:59 pm
by Snake
I took modafinil to boost my efficiency when I had exams. No changes in sexual area.

Re: Alpha:Beta activity in PSSD.

Unread postPosted: Tue Jan 08, 2019 1:15 am
by Rb26dett
I have a question for JayR. Are you suffering or have you suffered from PSSD? Are you healed? I suffer from PSSD since I took 5-htp 200mg for 9 days. Before, I was taking Paroxetine at 5mg for over 5 years and had never had any problems. Initially, my symptoms were worse: no erection, watery sperm, premature ejaculation and hypersensitivity. Over time, the sperm is thick and white again and when I am with my girlfriend, I have an erection, if I have had a withdrawal period of at least 3 days even the sensitivity and orgasm are good. The problem is that before I was horny 24/7 and I liked every woman I saw. Now I do not get over it anymore. Also, I went to the urologist and said that I have chronic prostatitis. How is it that the 5-htp made me chronic prostatitis? In addition, I suffer from weakness and I can no longer train myself. I lost 7kg of weight.

Re: Alpha:Beta activity in PSSD.

Unread postPosted: Tue Jan 08, 2019 1:42 am
by magnilo
very interesting topic, i look forward to some discussion and maybe experimentation! :)
from my understanding erection is a "mix" between vasoconstriction and vasodilation
ive tought that too much vasodilation might actually be the base reason for "not keeping it up" (aka venous leakage i believe)
so im a bit skeptic about the doxazosin?

also, in the past i used to take pseudoephedrine for nasal congestion, and i noticed it promoted wakefullness and i had the impression i could climax better
would you say pseudoephedrine could do this, too?
actually i have a girl coming over today so i could give it a go to double check lol

Re: Alpha:Beta activity in PSSD.

Unread postPosted: Tue Jan 08, 2019 10:55 am
by JayR
Rb26dett wrote:I have a question for JayR. Are you suffering or have you suffered from PSSD? Are you healed? I suffer from PSSD since I took 5-htp 200mg for 9 days. Before, I was taking Paroxetine at 5mg for over 5 years and had never had any problems. Initially, my symptoms were worse: no erection, watery sperm, premature ejaculation and hypersensitivity. Over time, the sperm is thick and white again and when I am with my girlfriend, I have an erection, if I have had a withdrawal period of at least 3 days even the sensitivity and orgasm are good. The problem is that before I was horny 24/7 and I liked every woman I saw. Now I do not get over it anymore. Also, I went to the urologist and said that I have chronic prostatitis. How is it that the 5-htp made me chronic prostatitis? In addition, I suffer from weakness and I can no longer train myself. I lost 7kg of weight.

Have suffered* - although still suffer from occasional Anhedonia and rely on stimulants to get work done. However, the sexual symptoms of pretty much gone...there is some variation depending on what Substances/Stressors I put in my Body...so like for me...Adderall and Nicotine - though I RELY on them...they tend to have a negative impact on erectile function....however, what I've noticed is this is no longer true when I use Metergoline (Liserdol) at 12 MG...this counteracts ALL vasoconstriction from Adderall - that TELLS ME that the vasoconstriction from Adderall is primarily Serotonin-related!!!

Re: Alpha:Beta activity in PSSD.

Unread postPosted: Tue Jan 08, 2019 1:28 pm
by JayR
zadig777 wrote:@jayR what about being good enough and sharing ur pssd recovery if u rly had it?
whats ur curently on?
-yohimbe
-prasozin
-cialis
-dextroamphetamine
-metergoline

u use these or none of this?
sry but i look u as another internet prophet until u give the community something realistic and sincere


regards

PSSD recovery happened 2.5 years ago brother! Paleo Diet and 6-Months of Icariin 60 + Berberine supplementation.
I use Yohimbine occasionally, Cialis daily and dextroamphetamine daily (usually). Metergoline, when I have it around I use it!

Re: Alpha:Beta activity in PSSD.

Unread postPosted: Tue Jan 08, 2019 1:36 pm
by JayR
zadig777 wrote:u use dextro for what?
im thinking if it would help me in pssd
but on the other hand i dont respond to drugs or alcohol so idk if it would be effective at all :P
could u get drunk while u had pssd?
hows the drug u produce production going?
why arent u active on ur forumotion regarding pssd anymore?

i have some questions for u if u have free time for my specific case
i would like to discuss on ur forumotion if posible

best regards
:))

Dextro for focus & Motivation, generally. It does have a libido-enhancing effect but it is stronger when paired with Metergoline.
E-Mail me: area1255x@gmail.com

Re: Alpha:Beta activity in PSSD.

Unread postPosted: Tue Jan 08, 2019 1:47 pm
by JayR
zadig777 wrote:i emailed u tnx
can u plz tell me where do u get the dextro and meter
i ordered meter from idealabs but didnt get it yet so if u know alternative im happy to listen
cheers!

goldpharma.cn sells Metergoline tablets.

Re: Alpha:Beta activity in PSSD.

Unread postPosted: Tue Jan 08, 2019 2:16 pm
by Snake
JayR wrote:
zadig777 wrote:@jayR what about being good enough and sharing ur pssd recovery if u rly had it?
whats ur curently on?
-yohimbe
-prasozin
-cialis
-dextroamphetamine
-metergoline

u use these or none of this?
sry but i look u as another internet prophet until u give the community something realistic and sincere


regards

PSSD recovery happened 2.5 years ago brother! Paleo Diet and 6-Months of Icariin 60 + Berberine supplementation.
I use Yohimbine occasionally, Cialis daily and dextroamphetamine daily (usually). Metergoline, when I have it around I use it!


How can you state that you're cured if you're taking cialis daily?