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"Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine"

This is a place to post research you have done on the topic along with your conclusions.

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"Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine"

Unread postby fakeaccount » Sat Feb 09, 2019 1:57 pm

https://www.mdpi.com/2077-0383/8/2/133/
https://www.mdpi.com/2077-0383/8/2/133/pdf
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Re: "Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosin

Unread postby Snake » Sat Feb 09, 2019 2:33 pm

Doesn't sound good.
Finding a cure is only a matter of time! Never quit!
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Re: "Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosin

Unread postby Blueturtle » Sat Feb 09, 2019 4:06 pm

This looks like good research, thank you for sharing this.

Yup. Even more data implicating dopamine in PSSD, so many of the symptoms of PSSD seem to implicate dopamine, such as the emotional blunting some have reported. Also explains why some folks here (including myself) have gotten at least temporarily better with dopamine medications.
PSSD from citalopram.
Took it Winter 2012-Summer 2016
Cut cold turkey. Symptoms include genital anesthesia, ejaculatory anhedonia, low libido, Burning/tingling genital pain.
My story: viewtopic.php?f=14&t=2536
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Re: "Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosin

Unread postby anacleta » Sun Feb 10, 2019 1:45 am

Who contacts the authors of this research, asking them about the PSSD?


To try to connect this tyrosine to the neurosteroid theory, you can search with keywords: tyrosine allopregnanolone, tyrosine estrogens. Is the amino acid tyrosine the cause or consequence, if any, of altered neurosteroids? (however we still await the results of the Melcangi study)

Transcriptional regulation of tyrosine hydroxylase by estrogen: opposite effects with estrogen receptors alpha and beta and interactions with cyclic AMP.
https://www.ncbi.nlm.nih.gov/pubmed/15935066

..
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Re: "Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosin

Unread postby Snake » Sun Feb 10, 2019 2:41 am

anacleta wrote:Who contacts the authors of this research, asking them about the PSSD?


To try to connect this tyrosine to the neurosteroid theory, you can search with keywords: tyrosine allopregnanolone, tyrosine estrogens. Is the amino acid tyrosine the cause or consequence, if any, of altered neurosteroids? (however we still await the results of the Melcangi study)

Transcriptional regulation of tyrosine hydroxylase by estrogen: opposite effects with estrogen receptors alpha and beta and interactions with cyclic AMP.
https://www.ncbi.nlm.nih.gov/pubmed/15935066

..


Someone should contact them for sure. @Ghost, are you there? :D
Finding a cure is only a matter of time! Never quit!
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Re: "Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosin

Unread postby Marksanchez397 » Sun Feb 10, 2019 2:57 am

https://www.mcgill.ca/newsroom/channels ... ons-266833
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Re: "Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosin

Unread postby Mesolimbo » Sun Feb 10, 2019 3:10 am

N-acetylcysteine (NAC) upregulates tyrosine hydroxylase by 300%
https://www.ncbi.nlm.nih.gov/pubmed/11742214

And Panax Ginseng downregulates it.
2 years on Venlafaxine destroyed my libido and gave me ED.

Venlafaxine upregulates 3α-HSD enzyme, leading to pronounced increase in progesterone -> allopregnanolone level. Progesterone is used in male chemical castration for sex offenders. Go figure
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Re: "Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosin

Unread postby iull1k » Sun Feb 10, 2019 3:14 am

Do you remember that a lot of us had high Progesterone?


The progesterone (P(4)) rise on proestrous afternoon is associated with dephosphorylation of tyrosine hydroxylase (TH) and reduced TH activity in the stalk-median eminence (SME), which contributes to the proestrous prolactin surge in rats.

Progesterone Induces Dephosphorylation and Inactivation of Tyrosine Hydroxylase in Rat Hypothalamic Dopaminergic Neurons
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