Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-co

[north4]

Psychopharmacology (Berl). 2012 Oct;223(4):381-8. Epub 2012 May 3.
Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial.
Modabbernia A1, Sohrabi H, Nasehi AA, Raisi F, Saroukhani S, Jamshidi A, Tabrizi M, Ashrafi M, Akhondzadeh S.
Author information
Abstract
RATIONALE:

Saffron (Crocus sativus L.) has shown aphrodisiac effects in some animal and human studies.
OBJECTIVES:

To assess the efficacy and tolerability of saffron in fluoxetine-related sexual dysfunction.
METHODS:

This was a 4-week randomized double-blind placebo-controlled study. Thirty-six married male patients with major depressive disorder whose depressive symptoms had been stabilized on fluoxetine and had subjective complaints of sexual impairment entered the study. The patients were randomly assigned to saffron (15 mg twice per day) or placebo for 4 weeks. International Index of Erectile Function scale was used to assess sexual function at baseline and weeks 2 and 4.
RESULTS:

Thirty patients finished the study. Baseline characteristics as well as baseline and final depressive symptoms scores were similar between the two groups. Effect of time × treatment interaction on the total score was significant [Greenhouse-Geisser-corrected, F (1.444, 40.434) = 6.154, P = 0.009]. By week 4, saffron resulted in significantly greater improvement in erectile function (P < 0.001) and intercourse satisfaction domains (P = 0.001), and total scores (P < 0.001) than the placebo group. Effect of saffron did not differ significantly from that of placebo in orgasmic function (P = 0.095), overall satisfaction (P = 0.334), and sexual desire (P = 0.517) domains scores. Nine patients (60%) in the saffron group and one patient (7%) in the placebo group achieved normal erectile function (score > 25 on erectile function domain) at the end of the study (P value of Fisher's exact test = 0.005). Frequency of side effects were similar between the two groups.
CONCLUSIONS:

Saffron is a tolerable and efficacious treatment for fluoxetine-related erectile dysfunction.

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10g price is around 40 euros in germany

http://www.ncbi.nlm.nih.gov/pubmed/?ter ... depression

[Ghost]

try it

[north4]

i will

[north4]

nothing...

[raven100]

nothing noticeable for me either, but makes for nice tea

[theloneranger86]

Just started my trial . Doing 15-30mg twice a day for 45 days. Today was Day 1. Update you guys when I get done at day 45 .

[JayR]

I did notice effects on this but they die out quickly.

[magnilo]

I'll Try too, posting as a reminder to myself

[theloneranger86]

erections much fuller for sure. maintaining them still an issue. I guess its only while I take saffron , and they would die out once I stop.

[theloneranger86]

I would surely ask more people to give it a try, maybe itll cure milder forms of PSSD - mainly those who's erections are not as full as they'd like them to be