sylv wrote:My theory is the SSRIs, when taken for a long term, are first of all creating "the ground for PSSD" by inducing persistent brain changes, probably on microarchitectural - dendritic / axons level. Then you are starting to be susceptible to get PSSD on any occasion, you need just inducing agent which brings PSSD from it's non-active state to active state. This may be SSRI itself, An atypical Antidepressant, a neuroleptic, a mood stabilizer, or even high stress. You suddenly, "out of nowhere" get emotionally blunted, asexual and your genitals, or whole body starts to be anaesthetised.
This may explain why people who have used SSRI extensively before, get PSSD after abrupt withdrawal or when they've switched to an another drug.
I've taken clomipramine myself for 6 months almost without AE, felt some emotional blunting at the end which let me to go cold turkey. The anxiety was coming back, so short after, I started the escitalopram only to get a sudden lobotomy-like emotional blunting and full sexual dysfunction with anaesthesia after just 3 days of use. The symptoms are continuously present to this day, almost 6 years has passed
How are you doing with imagination, logical thinking, attention, abstract thinking? Thank you