...

[iii1i1i1]

.

[Snake]

Maybe he was just ill in the first place and AD had nothing to do with it?

[TalkingAntColony]

Cool. With all the gut connections I decided to get a stool test. Will have results in a few weeks and decide what to do. Ironically I'm hoping I test positive for something because a negative result could be a false negative, as some people had to do multiple tests to detect the pathogen.

[iii1i1i1]

...

[Dryed]

No one's will be cured of pssd from just antibiotics, I've take plenty of them since July for cystitis and for sure nothing is changed.
If exist microbioma alterations is a consequence not a cause for our conditions.

[TalkingAntColony]

Guys, let's not be closed minded and dogmatic. There is evidence the gut microbiome can influence hormones and epigenetics. There are also studies suggesting SSRI's and finasteride can alter the gut microbiome. See a lot of the recent threads in the research section.

[Moran22]

Hi

I found next to the story (which is known to us) of a PFS visitor with whom the histolytica was found, one more story of cure by diagnosing the parasite and curing it through antibiotics and medications.

https://www.acne.org/messageboard/topic/295030-repairing-the-long-term-damage-from-accutane/?page=359

At the risk of being repetitive, here's a link to stories of two guys who CURED themselves of PFS, all sexual, mental, and physical side effects, using two antibiotics and many probiotics, after being tested positive for parasites.

http://www.allthingsmale.com/community/ ... col.26219/transfers Amiens

@accutanesuckss, do you know specifically what two parasites you have? Maybe you just need these two antibiotics as well! Cure in two weeks!

So cool

[been_too_long]

Guys, let's not be closed minded and dogmatic. There is evidence the gut microbiome can influence hormones and epigenetics. There are also studies suggesting SSRI's and finasteride can alter the gut microbiome. See a lot of the recent threads in the research section.

Just took a look at recent threads in research section and not really finding what your referring to there.. but that's not important.

I would ask the same as you; lets not be so closed minded when it comes to those of us that have ruled out this whole gut fad that's taken over the forum of late. There is several of us that has been on various antibiotics and antifungals and not seen even a hint of improvement. Personally Ive probably been on antibiotics over 20 times since coming down with PSSD due to surgeries and other circumstances. I know Ive been on antifungals over 8 times in last two years (3 different types.) So its not just because the gut theory makes no sense (and it doesn't) that we dismiss it.

While there is results leaning towards "gut microbiome can influence hormones and epigenetics," it is not conclusive nor accepted wide scale medically on to what extent. It might.. it might not.. I don't know. But what I do know is there has not been a single proven link for us to just accept it as a likely cause of PSSD. No matter how hard it is shoved down our throats; there is several of us that are not being swayed. If its the holy grail we have been looking for, then why haven't more of you gone out and cured yourselves???????!!!!!!????? The answer is obvious.. it is a dead end. If you all want to keep at the theory so dogmatically, then more power to you, its your time to waste Im just saying, understand why we are not buying into it and scoff at how much attention its getting.

also.. just for the record. "Studies suggesting" does not mean squat in the medical field. You can find a study that suggests something for every crackpot theory in the world.

[TalkingAntColony]

not be so closed minded when it comes to those of us that have ruled out this whole gut fad

I am not refusing to accept that some people don't believe there is merit to the gut theories. Rather, I am taking issue with people's negative, low-effort posts that don't add anything to the forum. You are free to argue against theories but I'd just rather not see the forum devolve into "Stop posting this, you're just wrong" type of discussions.

It is not enough to have taken some antibiotics to rule out gut issues. It could be the case you have resistant bacterial strains that did not get completely eliminated by whatever particular antibiotics you took. It could be the case that you lack proper beneficial bacteria diversity and/or amounts, which antibiotics could actually make worse.

there has not been a single proven link for us to just accept it as a likely cause of PSSD

You don't need accept it as a likely cause. For it to be worth discussing, it just has to be not ruled out. No one has established a direct link between epigenetic modifications and PSSD symptoms. Yet, you appear enthusiastic about that theory. Yes, citalopram induced various epigenetic changes in vitro, but how do we know those changes caused PSSD? The changes could be benign, or less severe in vivo, or not systemic and quickly reversed in vivo. It doesn't explain why most people who take citalopram don't experience PSSD. It seems you hold gut theories to a higher burden of proof than pure epigenetic theories. I am enthusiastic about epigenetic theories too, but I'm just saying, it's not proven either.

If you like the epigenome theories, perhaps the gut microbiome could be a therapeutic target:

Epigenome targeting by probiotic metabolites
Gut bacteria produce natural HDAC inhibitors at high enough levels to induce epigenetic changes (upregulation), which is demonstrated in humans.

H. pylori modifies methylation of global genomic DNA
Gut pathogen can cause epigenetic downregulation

Dysbiosis of Gut Microbiome and Its Impact on Epigenetic Regulation
Dysbiosis (improper amount/diveersity of beneficial bacteria) effects the epigenome, and "re-balancing dysbiosis through transplantation of the healthy gut microbiome could constitute an effective therapeutic strategy."

Evidence the gut microbiome is changed in us:

Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis neuroinflammation, and gut microbiota composition
Rats given finasteride (PFS) showed altered gut microbiome composition, among other changes

SSRI fluoxetine was shown to cause genetic mutations that produce multiple antibiotic resistance in E. coli

A Monomicrobial Infection Of Staphylococcus Aureus Associated With Erectile Dysfunction - A CASE REPORT

Reactive Oxygen Production Induced by the Gut Microbiota
ROS and NADPH activity can be induced by gut bacteria, which is a plausible association between the gut and decreased NO production seen in the below study:

Chronic escitalopram treatment induces erectile dysfunction by decreasing nitric oxide bioavailability
"suggesting that the inhibitory effect is caused by a decrease in nitric oxide bioavailability mediated by increased NADPH oxidase and reactive oxygen species production." If SSRI cause gut microbiome changes which increase ROS and NADPH activity, there is a plausible link.

More articles linking the gut microbiome to sexual and mental health

Depression is associated with gut dysbiosis, SSRIs have antimicrobial effects, and some antibiotics have antidepressant effects. Perhaps us depressed SSRI users had poor guts to begin with, and SSRI caused further unbalance.

E histolytica secretes serotonin, causing a sustained secretory diarrhea in some people. Patients infected with E. histolytica have been found to have highly elevated serum serotonin levels, which returned to normal following resolution of the infection. Some PSSD sufferers have reported sustained diarrhea. Some PSSD theories involved desensitized serotonin receptors which could be due to sustained high serotonin levels.


Success stories related to the gut microbiome:

Blauwasser cured from multiple fecal transplants.

Raven is seeing improvements by eliminating E histolytica.

PFS sufferer cured by eliminating E hystolytica

PFS sufferer brongfogboy saw improvements with various methods targeting the gut microbiome.

afx was cured while on antifungals and probiotics

user Dead saw temporary improvements with probiotic enemas

Former PFS sufferer DutSucks contends that gut-related therapies helped him

Another similar PFS success story

Yet another gut-related PFS success story

Maxbook was healed with pramipexole, which may have antimicrobial properties.

Louis was cured by mainserin, which has antimicrobial properties.

Two people improved on St Johns Wort, which has antimicrobial and antiviral properties.

ggggg123 was cured by licorice root. Licorice root has antimicrobial and antiviral properties.

acrostics22 was cured while taking a number of herbs with antimicrobial properties.


So with all these connections to the gut, I hope you will tolerate these discussions on the forum.

[Dryed]

Consequence not causes.. We need to not forget that SSRI strongly interact with estrogen receptor and they induced an impaired neurosteroidogenesis